Gene Symbol | PIWIL4 |
Entrez ID | 143689 |
Uniprot ID | Q7Z3Z4 |
Description | piwi-like RNA-mediated gene silencing 4 |
Chromosomal Location | chr11: 94,543,840-94,621,421 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006417 |
regulation of translation |
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA. |
IEA |
BP |
GO:0007275 |
multicellular organism development |
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). |
IEA |
BP |
GO:0007283 |
spermatogenesis |
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis. |
ISS |
BP |
GO:0030154 |
cell differentiation |
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
IEA |
BP |
GO:0031047 |
gene silencing by RNA |
Any process in which RNA molecules inactivate expression of target genes. |
ISS |
BP |
GO:0034587 |
piRNA metabolic process |
The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. |
ISS |
BP |
GO:0043046 |
DNA methylation involved in gamete generation |
The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete. |
ISS |
BP |
GO:0051321 |
meiotic cell cycle |
Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. |
IEA |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
ISS |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
ISS |
CC |
GO:0043186 |
P granule |
A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes. |
ISS |
CC |
GO:0071547 |
piP-body |
A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway. |
ISS |
MF |
GO:0034584 |
piRNA binding |
Interacting selectively and non-covalently with a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. |
ISS |
Domain ID | Description |
---|---|
IPR003100 |
PAZ domain |
IPR003165 |
Piwi domain |
IPR012337 |
Ribonuclease H-like domain |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa04320 |
Dorso-ventral axis formation |
KEGG |
UMLS CUI | UMLS Term |
---|---|
C0028960 |
Oligospermia |
C1263846 |
Attention Deficit Hyperactivity Disorder |
Tissue | Cell Type |
---|---|
appendix |
lymphoid tissue |
lung |
macrophages |
lymph node |
germinal center cells |
skin |
Langerhans |
spleen |
cells in white pulp |
tonsil |
germinal center cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
FKBP5 |
2289 |
Q13451 |
0.49 |
HSP90AA1 |
3320 |
P07900 |
0.49 |
FKBP6 |
8468 |
O75344 |
0.49 |
NUDC |
10726 |
Q9Y266 |
0.49 |
PTGES3 |
10728 |
Q15185 |
0.49 |
NUDCD3 |
23386 |
Q8IVD9 |
0.49 |
CACYBP |
27101 |
Q9HB71 |
0.49 |
AARSD1 |
80755 |
Q9BTE6 |
0.49 |
DICER1 |
23405 |
Q9UPY3 |
0.86 |
AGO2 |
27161 |
Q9UKV8 |
0.55 |
RELA |
5970 |
Q04206 |
0.63 |