Protein Description

Gene Symbol PIWIL4
Entrez ID 143689
Uniprot ID Q7Z3Z4
Description piwi-like RNA-mediated gene silencing 4
Chromosomal Location chr11: 94,543,840-94,621,421
Ontology GO ID GO Term Definition Evidence

BP

GO:0006417

regulation of translation

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.

IEA

BP

GO:0007275

multicellular organism development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

IEA

BP

GO:0007283

spermatogenesis

The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.

ISS

BP

GO:0030154

cell differentiation

The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.

IEA

BP

GO:0031047

gene silencing by RNA

Any process in which RNA molecules inactivate expression of target genes.

ISS

BP

GO:0034587

piRNA metabolic process

The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.

ISS

BP

GO:0043046

DNA methylation involved in gamete generation

The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete.

ISS

BP

GO:0051321

meiotic cell cycle

Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.

IEA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

ISS

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

ISS

CC

GO:0043186

P granule

A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.

ISS

CC

GO:0071547

piP-body

A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway.

ISS

MF

GO:0034584

piRNA binding

Interacting selectively and non-covalently with a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.

ISS

Domain ID Description

IPR003100

PAZ domain

IPR003165

Piwi domain

IPR012337

Ribonuclease H-like domain

Pathway ID Pathway Term Pathway Source

hsa04320

Dorso-ventral axis formation

KEGG

UMLS CUI UMLS Term

C0028960

Oligospermia

C1263846

Attention Deficit Hyperactivity Disorder

Tissue Cell Type

appendix

lymphoid tissue

lung

macrophages

lymph node

germinal center cells

skin

Langerhans

spleen

cells in white pulp

tonsil

germinal center cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

FKBP5

2289

Q13451

0.49

HSP90AA1

3320

P07900

0.49

FKBP6

8468

O75344

0.49

NUDC

10726

Q9Y266

0.49

PTGES3

10728

Q15185

0.49

NUDCD3

23386

Q8IVD9

0.49

CACYBP

27101

Q9HB71

0.49

AARSD1

80755

Q9BTE6

0.49

DICER1

23405

Q9UPY3

0.86

AGO2

27161

Q9UKV8

0.55

RELA

5970

Q04206

0.63