Protein Description

Gene Symbol PNCK
Entrez ID 139728
Uniprot ID Q6P2M8
Description pregnancy up-regulated nonubiquitous CaM kinase
Chromosomal Location chrX: 153,669,730-153,689,010
Ontology GO ID GO Term Definition Evidence

BP

GO:0006468

protein phosphorylation

The process of introducing a phosphate group on to a protein.

IEA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IEA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IEA

MF

GO:0004683

calmodulin-dependent protein kinase activity

Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin.

IEA

MF

GO:0005516

calmodulin binding

Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.

IEA

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

Domain ID Description

IPR000719

Protein kinase domain

IPR008271

Serine/threonine-protein kinase, active site

IPR011009

Protein kinase-like domain

IPR017441

Protein kinase, ATP binding site

IPR020636

Calcium/calmodulin-dependent/calcium-dependent protein kinase

No pathways found.

No diseases found.

Tissue Cell Type

appendix

glandular cells

epididymis

glandular cells

gallbladder

glandular cells

pancreas

exocrine glandular cells

placenta

decidual cells

skin

fibroblasts

skin

keratinocytes

stomach

glandular cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

No partners found.