Protein Description

Gene Symbol EGFR
Entrez ID 1956
Uniprot ID P00533
Description epidermal growth factor receptor
Chromosomal Location chr7: 55,019,021-55,211,628
Ontology GO ID GO Term Definition Evidence

BP

GO:0000165

MAPK cascade

An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.

TAS

BP

GO:0000186

activation of MAPKK activity

The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).

IEA

BP

GO:0001503

ossification

The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.

NAS

BP

GO:0001892

embryonic placenta development

The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.

IEA

BP

GO:0001934

positive regulation of protein phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.

IDA

BP

GO:0001942

hair follicle development

The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open.

IEA

BP

GO:0006412

translation

The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome.

IEA

BP

GO:0006950

response to stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

NAS

BP

GO:0006970

response to osmotic stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.

IEA

BP

GO:0006979

response to oxidative stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

IEA

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

IDA|TAS

BP

GO:0007166

cell surface receptor signaling pathway

A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.

IDA

BP

GO:0007173

epidermal growth factor receptor signaling pathway

A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.

IDA|TAS

BP

GO:0007202

activation of phospholipase C activity

The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.

TAS

BP

GO:0007435

salivary gland morphogenesis

The process in which the anatomical structures of the salivary gland are generated and organized.

IEA

BP

GO:0007494

midgut development

The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine.

IEA

BP

GO:0007611

learning or memory

The acquisition and processing of information and/or the storage and retrieval of this information over time.

ISS

BP

GO:0007623

circadian rhythm

Any biological process in an organism that recurs with a regularity of approximately 24 hours.

IEA

BP

GO:0008283

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

IDA

BP

GO:0008284

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

IDA|IMP

BP

GO:0010960

magnesium ion homeostasis

Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell.

IEA

BP

GO:0014066

regulation of phosphatidylinositol 3-kinase signaling

Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.

TAS

BP

GO:0016101

diterpenoid metabolic process

The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units.

IEA

BP

GO:0016337

single organismal cell-cell adhesion

The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism.

IMP

BP

GO:0018108

peptidyl-tyrosine phosphorylation

The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.

IEA

BP

GO:0021795

cerebral cortex cell migration

The orderly movement of cells from one site to another in the cerebral cortex.

IEA

BP

GO:0030307

positive regulation of cell growth

Any process that activates or increases the frequency, rate, extent or direction of cell growth.

IDA

BP

GO:0030324

lung development

The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.

IEA

BP

GO:0030335

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

IMP

BP

GO:0031659

positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle

Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G1/S transition of the cell cycle.

IDA

BP

GO:0032930

positive regulation of superoxide anion generation

Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell.

IEA

BP

GO:0033590

response to cobalamin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus.

IEA

BP

GO:0033594

response to hydroxyisoflavone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyisoflavone stimulus.

IEA

BP

GO:0035413

positive regulation of catenin import into nucleus

Any process that increases the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus.

IMP

BP

GO:0035690

cellular response to drug

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.

IEA

BP

GO:0038128

ERBB2 signaling pathway

A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair.

TAS

BP

GO:0042059

negative regulation of epidermal growth factor receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.

TAS

BP

GO:0042060

wound healing

The series of events that restore integrity to a damaged tissue, following an injury.

IEA

BP

GO:0042177

negative regulation of protein catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.

IDA

BP

GO:0042327

positive regulation of phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.

IDA

BP

GO:0042698

ovulation cycle

The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years.

IEA

BP

GO:0042743

hydrogen peroxide metabolic process

The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.

IEA

BP

GO:0043006

activation of phospholipase A2 activity by calcium-mediated signaling

A series of molecular signals that leads to the upregulation of calcium-dependent phospholipase A2 activity in response to the signal.

TAS

BP

GO:0043066

negative regulation of apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.

IMP

BP

GO:0043406

positive regulation of MAP kinase activity

Any process that activates or increases the frequency, rate or extent of MAP kinase activity.

IDA

BP

GO:0043547

positive regulation of GTPase activity

Any process that activates or increases the activity of a GTPase.

IEA

BP

GO:0043586

tongue development

The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech.

IEA

BP

GO:0045429

positive regulation of nitric oxide biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.

IDA

BP

GO:0045739

positive regulation of DNA repair

Any process that activates or increases the frequency, rate or extent of DNA repair.

IDA

BP

GO:0045740

positive regulation of DNA replication

Any process that activates or increases the frequency, rate or extent of DNA replication.

IDA

BP

GO:0045780

positive regulation of bone resorption

Any process that activates or increases the frequency, rate or extent of bone resorption.

IEA

BP

GO:0045907

positive regulation of vasoconstriction

Any process that activates or increases the frequency, rate or extent of vasoconstriction.

IEA

BP

GO:0045909

positive regulation of vasodilation

Any process that activates or increases the frequency, rate or extent of vasodilation.

IEA

BP

GO:0045930

negative regulation of mitotic cell cycle

Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.

IEA

BP

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IDA

BP

GO:0046777

protein autophosphorylation

The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).

IMP

BP

GO:0046854

phosphatidylinositol phosphorylation

The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.

IEA

BP

GO:0048015

phosphatidylinositol-mediated signaling

A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.

TAS

BP

GO:0048143

astrocyte activation

A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.

IEA

BP

GO:0048146

positive regulation of fibroblast proliferation

Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.

IEA

BP

GO:0048546

digestive tract morphogenesis

The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed.

IEA

BP

GO:0048661

positive regulation of smooth muscle cell proliferation

Any process that activates or increases the rate or extent of smooth muscle cell proliferation.

IEA

BP

GO:0048812

neuron projection morphogenesis

The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.

IEA

BP

GO:0050679

positive regulation of epithelial cell proliferation

Any process that activates or increases the rate or extent of epithelial cell proliferation.

IDA

BP

GO:0050729

positive regulation of inflammatory response

Any process that activates or increases the frequency, rate or extent of the inflammatory response.

IEA

BP

GO:0050730

regulation of peptidyl-tyrosine phosphorylation

Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.

IMP

BP

GO:0050999

regulation of nitric-oxide synthase activity

Any process that modulates the activity of the enzyme nitric-oxide synthase.

IDA

BP

GO:0051205

protein insertion into membrane

The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers.

TAS

BP

GO:0051592

response to calcium ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.

IEA

BP

GO:0051897

positive regulation of protein kinase B signaling

Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.

IMP

BP

GO:0051968

positive regulation of synaptic transmission, glutamatergic

Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.

IEA

BP

GO:0060571

morphogenesis of an epithelial fold

The morphogenetic process in which an epithelial sheet bends along a linear axis.

IEA

BP

GO:0061029

eyelid development in camera-type eye

The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye.

IEA

BP

GO:0070141

response to UV-A

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm.

IDA

BP

GO:0070374

positive regulation of ERK1 and ERK2 cascade

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.

IDA|IMP

BP

GO:0071230

cellular response to amino acid stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.

IEA

BP

GO:0071260

cellular response to mechanical stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.

IEA

BP

GO:0071364

cellular response to epidermal growth factor stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.

ISS

BP

GO:0071392

cellular response to estradiol stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.

IDA

BP

GO:0071549

cellular response to dexamethasone stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.

IEA

BP

GO:0097421

liver regeneration

The regrowth of lost or destroyed liver.

IEA

BP

GO:1902722

positive regulation of prolactin secretion

Any process that activates or increases the frequency, rate or extent of prolactin secretion.

IEA

BP

GO:1903800

positive regulation of production of miRNAs involved in gene silencing by miRNA

Any process that activates or increases the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA.

IMP

BP

GO:2000145

regulation of cell motility

Any process that modulates the frequency, rate or extent of cell motility.

TAS

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

IEA

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

NAS

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005768

endosome

A vacuole to which materials ingested by endocytosis are delivered.

IDA

CC

GO:0005789

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

IEA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA|TAS

CC

GO:0005913

cell-cell adherens junction

An adherens junction which connects a cell to another cell.

IDA

CC

GO:0005925

focal adhesion

Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.

IDA

CC

GO:0009986

cell surface

The external part of the cell wall and/or plasma membrane.

IDA

CC

GO:0010008

endosome membrane

The lipid bilayer surrounding an endosome.

IDA

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IDA

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

CC

GO:0016323

basolateral plasma membrane

The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.

IDA

CC

GO:0016324

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

IEA

CC

GO:0030122

AP-2 adaptor complex

A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).

TAS

CC

GO:0031901

early endosome membrane

The lipid bilayer surrounding an early endosome.

IDA

CC

GO:0031965

nuclear membrane

Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.

IEA

CC

GO:0043235

receptor complex

Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

IDA

CC

GO:0045121

membrane raft

Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.

IDA

CC

GO:0045202

synapse

The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

IEA

CC

GO:0048471

perinuclear region of cytoplasm

Cytoplasm situated near, or occurring around, the nucleus.

IEA

CC

GO:0070435

Shc-EGFR complex

A protein complex that contains the epidermal growth factor receptor (EGFR) and the adaptor protein Shc, and is involved in linking EGFR activation to the p21-Ras pathway.

ISS

CC

GO:0097489

multivesicular body, internal vesicle lumen

The volume enclosed by the membrane of the multivesicular body internal vesicle.

IDA

MF

GO:0001948

glycoprotein binding

Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans.

IEA

MF

GO:0003682

chromatin binding

Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.

IDA

MF

GO:0003690

double-stranded DNA binding

Interacting selectively and non-covalently with double-stranded DNA.

NAS

MF

GO:0004709

MAP kinase kinase kinase activity

Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.

NAS

MF

GO:0004713

protein tyrosine kinase activity

Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

EXP|IDA|IMP|TAS

MF

GO:0004714

transmembrane receptor protein tyrosine kinase activity

Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

TAS

MF

GO:0004716

receptor signaling protein tyrosine kinase activity

Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

IEA

MF

GO:0004888

transmembrane signaling receptor activity

Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.

IDA

MF

GO:0005006

epidermal growth factor-activated receptor activity

Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.

IDA|NAS

MF

GO:0005088

Ras guanyl-nucleotide exchange factor activity

Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.

TAS

MF

GO:0005178

integrin binding

Interacting selectively and non-covalently with an integrin.

IEA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005516

calmodulin binding

Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.

IEA

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

MF

GO:0019899

enzyme binding

Interacting selectively and non-covalently with any enzyme.

IPI

MF

GO:0019901

protein kinase binding

Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

IEA

MF

GO:0019903

protein phosphatase binding

Interacting selectively and non-covalently with any protein phosphatase.

IPI

MF

GO:0030235

nitric-oxide synthase regulator activity

Modulates the activity of nitric oxide synthase.

IDA

MF

GO:0031625

ubiquitin protein ligase binding

Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.

IPI

MF

GO:0042802

identical protein binding

Interacting selectively and non-covalently with an identical protein or proteins.

IPI

MF

GO:0046934

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+).

TAS

MF

GO:0046982

protein heterodimerization activity

Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.

IDA

MF

GO:0048408

epidermal growth factor binding

Interacting selectively and non-covalently with epidermal growth factor.

IEA

MF

GO:0051015

actin filament binding

Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.

IDA

MF

GO:0098641

cadherin binding involved in cell-cell adhesion

Any cadherin binding that occurs as part of the process of cell-cell adhesion.

IDA

Domain ID Description

IPR000494

Receptor L-domain

IPR000719

Protein kinase domain

IPR001245

Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR006211

Furin-like cysteine-rich domain

IPR006212

Furin-like repeat

IPR008266

Tyrosine-protein kinase, active site

IPR009030

Growth factor receptor cysteine-rich domain

IPR011009

Protein kinase-like domain

IPR016245

Tyrosine protein kinase, EGF/ERB/XmrK receptor

IPR017441

Protein kinase, ATP binding site

IPR020635

Tyrosine-protein kinase, catalytic domain

IPR032675

Leucine-rich repeat domain, L domain-like

IPR032778

Growth factor receptor domain 4

Pathway ID Pathway Term Pathway Source

hsa01521

EGFR tyrosine kinase inhibitor resistance

KEGG

hsa01522

Endocrine resistance

KEGG

hsa04010

MAPK signaling pathway

KEGG

hsa04012

ErbB signaling pathway

KEGG

hsa04014

Ras signaling pathway

KEGG

hsa04015

Rap1 signaling pathway

KEGG

hsa04020

Calcium signaling pathway

KEGG

hsa04060

Cytokine-cytokine receptor interaction

KEGG

hsa04066

HIF-1 signaling pathway

KEGG

hsa04068

FoxO signaling pathway

KEGG

hsa04072

Phospholipase D signaling pathway

KEGG

hsa04144

Endocytosis

KEGG

hsa04151

PI3K-Akt signaling pathway

KEGG

hsa04320

Dorso-ventral axis formation

KEGG

hsa04510

Focal adhesion

KEGG

hsa04520

Adherens junction

KEGG

hsa04540

Gap junction

KEGG

hsa04810

Regulation of actin cytoskeleton

KEGG

hsa04912

GnRH signaling pathway

KEGG

hsa04915

Estrogen signaling pathway

KEGG

hsa04921

Oxytocin signaling pathway

KEGG

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

KEGG

hsa05160

Hepatitis C

KEGG

hsa05200

Pathways in cancer

KEGG

hsa05205

Proteoglycans in cancer

KEGG

hsa05206

MicroRNAs in cancer

KEGG

hsa05212

Pancreatic cancer

KEGG

hsa05213

Endometrial cancer

KEGG

hsa05214

Glioma

KEGG

hsa05215

Prostate cancer

KEGG

hsa05218

Melanoma

KEGG

hsa05219

Bladder cancer

KEGG

hsa05223

Non-small cell lung cancer

KEGG

hsa05224

Breast cancer

KEGG

hsa05230

Central carbon metabolism in cancer

KEGG

hsa05231

Choline metabolism in cancer

KEGG

WP437

EGF/EGFR Signaling Pathway

WikiPathways

WP2431

Spinal Cord Injury

WikiPathways

WP1984

Integrated Breast Cancer Pathway

WikiPathways

WP306

Focal Adhesion

WikiPathways

WP2324

AGE/RAGE pathway

WikiPathways

WP3611

Photodynamic therapy-induced AP-1 survival signaling.

WikiPathways

WP3303

Rac1/Pak1/p38/MMP-2 pathway

WikiPathways

WP2363

Gastric Cancer Network 2

WikiPathways

WP2870

Extracellular vesicle-mediated signaling in recipient cells

WikiPathways

WP51

Regulation of Actin Cytoskeleton

WikiPathways

WP2828

Bladder Cancer

WikiPathways

WP3931

ESC Pluripotency Pathways

WikiPathways

WP3853

ERK Pathway in Huntington's Disease

WikiPathways

WP2643

Nanoparticle-mediated activation of receptor signaling

WikiPathways

WP382

MAPK Signaling Pathway

WikiPathways

WP2873

Aryl Hydrocarbon Receptor Pathway

WikiPathways

WP2868

TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer

WikiPathways

WP3927

BMP Signaling Pathway in Eyelid Development

WikiPathways

WP2261

Signaling Pathways in Glioblastoma

WikiPathways

WP3680

Association Between Physico-Chemical Features and Toxicity Associated Pathways

WikiPathways

WP2586

Aryl Hydrocarbon Receptor

WikiPathways

WP138

Androgen receptor signaling pathway

WikiPathways

WP673

ErbB Signaling Pathway

WikiPathways

WP3932

Focal Adhesion-PI3K-Akt-mTOR-signaling pathway

WikiPathways

h_agrPathway

Agrin in Postsynaptic Differentiation

BioCarta

h_At1rPathway

Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling

BioCarta

h_cblPathway

CBL mediated ligand-induced downregulation of EGF receptors

BioCarta

h_egfPathway

EGF Signaling Pathway

BioCarta

h_erkPathway

Erk1/Erk2 Mapk Signaling pathway

BioCarta

h_keratinocytePathway

Keratinocyte Differentiation

BioCarta

h_egfr_smrtePathway

Map Kinase Inactivation of SMRT Corepressor

BioCarta

h_mCalpainPathway

mCalpain and friends in Cell motility

BioCarta

h_ErbB3Pathway

Neuroregulin receptor degredation protein-1 Controls ErbB3 receptor recycling

BioCarta

h_cardiacegfPathway

Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy

BioCarta

h_her2Pathway

Role of ERBB2 in Signal Transduction and Oncology

BioCarta

h_spryPathway

Sprouty regulation of tyrosine kinase signals

BioCarta

h_telPathway

Telomeres, Telomerase, Cellular Aging, and Immortality

BioCarta

h_eea1Pathway

The role of FYVE-finger proteins in vesicle transport

BioCarta

h_tffPathway

Trefoil Factors Initiate Mucosal Healing

BioCarta

UMLS CUI UMLS Term

C0001418

Adenocarcinoma

C0005396

Bile Duct Neoplasms

C0005695

Bladder Neoplasm

C0007131

Non-Small Cell Lung Carcinoma

C0007137

Squamous Cell Carcinoma

C0007193

Cardiomyopathy, Dilated

C0007873

Uterine Cervical Neoplasm

C0009375

Colonic Neoplasms

C0009404

Colorectal Neoplasms

C0011860

Diabetes Mellitus, Non-Insulin-Dependent

C0014175

Endometriosis

C0014859

Esophageal Neoplasms

C0016978

Gallbladder Neoplasm

C0017636

Glioblastoma

C0017638

Glioma

C0018671

Head And Neck Neoplasms

C0021655

Insulin Resistance

C0024121

Lung Neoplasms

C0024667

Animal Mammary Neoplasms

C0024668

Mammary Neoplasms, Experimental

C0025500

Mesothelioma

C0027439

Nasopharyngeal Neoplasms

C0027626

Neoplasm Invasiveness

C0027627

Neoplasm Metastasis

C0027643

Neoplasm Recurrence, Local

C0029463

Osteosarcoma

C0030354

Papilloma

C0033578

Prostatic Neoplasms

C0034885

Rectal Neoplasms

C0038356

Stomach Neoplasms

C0085548

Autosomal Recessive Polycystic Kidney Disease

C0149925

Small Cell Carcinoma Of Lung

C0206686

Adrenocortical Carcinoma

C0206698

Cholangiocarcinoma

C0206726

Gliosarcoma

C0242656

Disease Progression

C0263454

Chloracne

C0334588

Giant Cell Glioblastoma

C0376634

Craniofacial Abnormalities

C0919267

Ovarian Neoplasm

C0993582

Arthritis, Experimental

C1458155

Mammary Neoplasms

C2239176

Liver Carcinoma

C2609414

Acute Kidney Injury

Tissue Cell Type

placenta

trophoblastic cells

No databases found.

Pubmed ID Author Year Title

15598877

Wood et al.

2005

Valproate-induced alterations in human theca cell gene expression: clues to the association between valproate use and metabolic side effects

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

FANCC

2176

Q00597

0.49

FKBP5

2289

Q13451

0.49

MPV17

4358

P39210

0.49

PPP2CB

5516

P62714

0.49

TGFB1

7040

P01137

0.49

MAPKAPK3

7867

Q16644

0.49

PICALM

8301

Q13492

0.49

ZNF510

22869

Q9Y2H8

0.49

NUDCD3

23386

Q8IVD9

0.49

FRAT2

23401

O75474

0.49

TRMO

51531

Q9BU70

0.49

NANS

54187

Q9NR45

0.49

PIGS

94005

Q96S52

0.49

ELF3

1999

P78545

0.52

FOS

2353

P01100

0.52

PLD1

5337

Q13393

0.52

PKIA

5569

P61925

0.52

ITSN1

6453

Q15811

0.52

SLC9A3R1

9368

O14745

0.52

SCAMP1

9522

O15126

0.52

DNAJC13

23317

O75165

0.52

DCBLD2

131566

Q96PD2

0.52

FAS

355

P25445

0.55

EPB41

2035

P11171

0.55

MAPK1

5594

P28482

0.55

MAP2K1

5604

Q02750

0.55

HIST3H3

8290

Q16695

0.55

EEA1

8411

Q15075

0.62

AAMP

14

Q13685

0.63

ACACA

31

Q13085

0.63

ACADSB

36

P45954

0.63

ACP1

52

P24666

0.63

ACTA2

59

P62736

0.63

ADAR

103

P55265

0.63

PARP1

142

P09874

0.63

AK4

205

P27144

0.63

AKT2

208

P31751

0.63

ALDH3A2

224

P51648

0.63

SLC25A5

292

P05141

0.63

APEX1

328

P27695

0.63

APOB

338

P04114

0.63

APRT

353

P07741

0.63

ARHGAP1

392

Q07960

0.63

ASNS

440

P08243

0.63

ATP2B1

490

P20020

0.63

ATP2B4

493

P23634

0.63

ATP5B

506

P06576

0.63

ATP5F1

515

P24539

0.63

ATR

545

Q13535

0.63

KIF1A

547

Q12756

0.63

BLM

641

P54132

0.63

CALR

811

P27797

0.63

CDK5

1020

Q00535

0.63

AP3S1

1176

Q92572

0.63

CLU

1191

P10909

0.63

TPP1

1200

O14773

0.63

CNP

1267

P09543

0.63

COL17A1

1308

Q9UMD9

0.63

COPA

1314

P53621

0.63

CSNK1A1

1452

P48729

0.63

CSNK2A1

1457

P68400

0.63

CSTA

1475

P01040

0.63

CTBP1

1487

Q13363

0.63

CTBP2

1488

P56545

0.63

CTGF

1490

P29279

0.63

CTNNA2

1496

P26232

0.63

DARS

1615

P14868

0.63

DHX9

1660

Q08211

0.63

DFNA5

1687

O60443

0.63

DHCR24

1718

Q15392

0.63

DNM2

1785

P50570

0.63

DSG2

1829

Q14126

0.63

EEF1B2

1933

P24534

0.63

EFNB1

1947

P98172

0.63

EIF2B1

1967

Q14232

0.63

EIF4G2

1982

P78344

0.63

STOM

2040

P27105

0.63

EPHB4

2050

P54760

0.63

EPRS

2058

P07814

0.63

ERCC2

2068

P18074

0.63

ERCC4

2072

Q92889

0.63

FBL

2091

P22087

0.63

ETF1

2107

P62495

0.63

EWSR1

2130

Q01844

0.63

FABP5

2171

Q01469

0.63

ACSL3

2181

O95573

0.63

FARSA

2193

Q9Y285

0.63

FDFT1

2222

P37268

0.63

FDPS

2224

P14324

0.63

FEN1

2237

P39748

0.63

FHL2

2274

Q14192

0.63

FLOT2

2319

Q14254

0.63

MTOR

2475

P42345

0.63

FUS

2521

P35637

0.63

GCLM

2730

P48507

0.63

GNAS

2778

P84996

0.63

GNB2

2783

P62879

0.63

GPS1

2873

Q13098

0.63

GRN

2896

P28799

0.63

PDIA3

2923

P30101

0.63

GSTT1

2952

P30711

0.63

HIST1H1E

3008

P10412

0.63

HSD17B10

3028

Q99714

0.63

HADHB

3032

P55084

0.63

HBA1 HBA2

3039

P69905

0.63

HCFC1

3054

P51610

0.63

HELLS

3070

Q9NRZ9

0.63

HK1

3098

P19367

0.63

HK2

3099

P52789

0.63

HLA-A

3105

P01892

0.63

HLA-A

3105

P30443

0.63

HNRNPF

3185

P52597

0.63

HNRNPK

3190

P61978

0.63

HSPA1L

3305

P34931

0.63

HSPD1

3329

P10809

0.63

IDH2

3418

P48735

0.63

IDH3A

3419

P50213

0.63

IDH3B

3420

O43837

0.63

IGFBP3

3486

P17936

0.63

IGHG1

3500

P01857

0.63

IGHG3

3502

P01860

0.63

IGKC

3514

P01834

0.63

ILF2

3608

Q12905

0.63

ILF3

3609

Q12906

0.63

ITGB4

3691

P16144

0.63

ITIH2

3698

P19823

0.63

STT3A

3703

P46977

0.63

ITPA

3704

Q9BY32

0.63

JAK1

3716

P23458

0.63

TNPO1

3842

Q92973

0.63

IPO5

3843

O00410

0.63

KRT1

3848

P04264

0.63

KRT5

3852

P13647

0.63

KRT6A

3853

P02538

0.63

KRT14

3861

P02533

0.63

LGALS8

3964

O00214

0.63

LMNA

4000

P02545

0.63

MARS

4141

P56192

0.63

MCM3

4172

P25205

0.63

MCM4

4173

P33991

0.63

MCM5

4174

P33992

0.63

MCM6

4175

Q14566

0.63

MCM7

4176

P33993

0.63

MGST1

4257

P10620

0.63

MMP14

4323

P50281

0.63

MYO1B

4430

O43795

0.63

MYO1C

4641

O00159

0.63

MYO1D

4642

O94832

0.63

NCL

4691

P19338

0.63

NDUFA4

4697

O00483

0.63

NDUFA9

4704

Q16795

0.63

NDUFS1

4719

P28331

0.63

NDUFS3

4722

O75489

0.63

NEDD8

4738

Q15843

0.63

NELL1

4745

Q92832

0.63

NQO2

4835

P16083

0.63

NPM1

4869

P06748

0.63

NSF

4905

P46459

0.63

OAT

4942

P04181

0.63

OPA1

4976

O60313

0.63

ORC5

5001

O43913

0.63

OSBP

5007

P22059

0.63

P4HB

5034

P07237

0.63

PC

5091

P11498

0.63

PDK1

5163

Q15118

0.63

PFKFB3

5209

Q16875

0.63

PFKM

5213

P08237

0.63

PIK3CB

5291

P42338

0.63

PKP2

5318

Q99959

0.63

PLK1

5347

P53350

0.63

PLS3

5358

P13797

0.63

PPP2R1A

5518

P30153

0.63

PPP2R1B

5519

P30154

0.63

PPP2R2A

5520

P63151

0.63

PPP2R5C

5527

Q13362

0.63

PPP2R5E

5529

Q16537

0.63

PPP6C

5537

O00743

0.63

PRIM1

5557

P49642

0.63

PRKAA1

5562

Q13131

0.63

PRKAG1

5571

P54619

0.63

PRKD1

5587

Q15139

0.63

MAP2K2

5605

P36507

0.63

MAP2K3

5606

P46734

0.63

EIF2AK2

5610

P19525

0.63

PSMD1

5707

Q99460

0.63

PSMD2

5708

Q13200

0.63

PTPRD

5789

P23468

0.63

ABCD3

5825

P28288

0.63

PXN

5829

P49023

0.63

RANBP1

5902

P43487

0.63

RANGAP1

5905

P46060

0.63

RARS

5917

P54136

0.63

RCN2

5955

Q14257

0.63

RFC3

5983

P40938

0.63

RFC4

5984

P35249

0.63

RFC5

5985

P40937

0.63

RPL4

6124

P36578

0.63

RPL17

6139

P18621

0.63

RPL22

6146

P35268

0.63

RPL38

6169

P63173

0.63

RPS4X

6191

P62701

0.63

RPS6KA3

6197

P51812

0.63

RPS15

6209

P62841

0.63

RPS15A

6210

P62244

0.63

RPS18

6222

P62269

0.63

S100A11

6282

P31949

0.63

ATXN2

6311

Q99700

0.63

SERPINB4

6318

P48594

0.63

SCD

6319

O00767

0.63

SDF2

6388

Q99470

0.63

SEL1L

6400

Q9UBV2

0.63

MAP2K4

6416

P45985

0.63

SFPQ

6421

P23246

0.63

SKIV2L

6499

Q15477

0.63

SLC1A5

6510

Q15758

0.63

SLC12A2

6558

P55011

0.63

SNAP25

6616

P60880

0.63

SNRPA1

6627

P09661

0.63

SNRPD1

6632

P62314

0.63

SNRPF

6636

P62306

0.63

SPRR1A

6698

P35321

0.63

SRPRA

6734

P08240

0.63

SSBP1

6742

Q04837

0.63

SSR1

6745

P43307

0.63

SSR4

6748

P51571

0.63

SULT1A1

6817

P50225

0.63

SYN1

6853

P17600

0.63

TAF4

6874

O00268

0.63

TARS

6897

P26639

0.63

TFRC

7037

P02786

0.63

THOP1

7064

P52888

0.63

TOP1

7150

P11387

0.63

TPM1

7168

P09493

0.63

TPM3

7170

P06753

0.63

TPM4

7171

P67936

0.63

TUBB2A

7280

Q13885

0.63

TUBG1

7283

P23258

0.63

TUFM

7284

P49411

0.63

UBB

7314

P0CG47

0.63

UBE2G2

7327

P60604

0.63

UCK2

7371

Q9BZX2

0.63

UMPS

7372

P11172

0.63

UQCRC2

7385

P22695

0.63

VARS

7407

P26640

0.63

VRK1

7443

Q99986

0.63

XPO1

7514

O14980

0.63

XRCC5

7520

P13010

0.63

YWHAE

7531

P62258

0.63

ARHGEF5

7984

Q12774

0.63

AAAS

8086

Q9NRG9

0.63

SLC7A5

8140

Q01650

0.63

CLPP

8192

Q16740

0.63

USP9X

8239

Q93008

0.63

SMC1A

8243

Q14683

0.63

NAA10

8260

P41227

0.63

HIST1H2BC; HIST1H2BE; HIST1H2BF; HIST1H2BG; HIST1H2BI

8339

P62807

0.63

SPARCL1

8404

Q14515

0.63

BCAR3

8412

O75815

0.63

CUL4B

8450

Q13620

0.63

IKBKAP

8518

O95163

0.63

YARS

8565

P54577

0.63

IRS2

8660

Q9Y4H2

0.63

EIF3F

8665

O00303

0.63

GBF1

8729

Q92538

0.63

TNFRSF10B

8795

O14763

0.63

SUCLA2

8803

Q9P2R7

0.63

DPM1

8813

O60762

0.63

EIF2B4

8890

Q9UI10

0.63

AP1S2

8905

P56377

0.63

AP1G2

8906

O75843

0.63

AP3D1

8943

O14617

0.63

SMC3

9126

Q9UQE7

0.63

AIFM1

9131

O95831

0.63

ARHGEF2

9181

Q92974

0.63

ZW10

9183

O43264

0.63

BUB3

9184

O43684

0.63

RPL23

9349

P62829

0.63

LONP1

9361

P36776

0.63

PLAA

9373

Q9Y263

0.63

COG1

9382

Q8WTW3

0.63

FADS2

9415

O95864

0.63

TECR

9524

Q9NZ01

0.63

VPS4B

9525

O75351

0.63

BAG2

9532

O95816

0.63

BCAR1

9564

P56945

0.63

BRE

9577

Q9NXR7

0.63

TTC37

9652

Q6PGP7

0.63

IPO13

9670

O94829

0.63

TTI1

9675

O43156

0.63

BZW1

9689

Q7L1Q6

0.63

PUM1

9698

Q14671

0.63

DOCK4

9732

Q8N1I0

0.63

TELO2

9894

Q9Y4R8

0.63

SGSM2

9905

O43147

0.63

OXSR1

9943

O95747

0.63

NUP153

9972

P49790

0.63

DOPEY2

9980

Q9Y3R5

0.63

AP1M2

10053

Q9Y6Q5

0.63

UBA2

10054

Q9UBT2

0.63

DNM1L

10059

O00429

0.63

ABCF2

10061

Q9UG63

0.63

HUWE1

10075

Q7Z6Z7

0.63

ACTR2

10097

P61160

0.63

NUBP2

10101

Q9Y5Y2

0.63

LRPPRC

10128

P42704

0.63

SUGP2

10147

Q8IX01

0.63

CEBPZ

10153

Q03701

0.63

TRIM28

10155

Q13263

0.63

SLC25A13

10165

Q9UJS0

0.63

PRMT3

10196

O60678

0.63

SPRY2

10253

O43597

0.63

UBE4B

10277

O95155

0.63

LANCL1

10314

O43813

0.63

TUBB3

10381

Q13509

0.63

TUBB4A

10382

P04350

0.63

TUBB4B

10383

P68371

0.63

CDIPT

10423

O14735

0.63

COG5

10466

Q9UP83

0.63

EIF3M

10480

Q7L2H7

0.63

CAP2

10486

P40123

0.63

HYOU1

10525

Q9Y4L1

0.63

IPO8

10526

O15397

0.63

IPO7

10527

O95373

0.63

ARFGEF1

10565

Q9Y6D6

0.63

TBL3

10607

Q12788

0.63

ATP5L

10632

O75964

0.63

EXOC5

10640

O00471

0.63

PTGES3

10728

Q15185

0.63

TUBGCP2

10844

Q9BSJ2

0.63

CLPX

10845

O76031

0.63

PPARGC1A

10891

Q9UBK2

0.63

EHD1

10938

Q9H4M9

0.63

AFG3L2

10939

Q9Y4W6

0.63

OS9

10956

Q13438

0.63

CKAP4

10970

Q07065

0.63

GCN1

10985

Q92616

0.63

IMMT

10989

Q16891

0.63

RER1

11079

O15258

0.63

STRAP

11171

Q9Y3F4

0.63

WDR6

11180

Q9NNW5

0.63

DDX20

11218

Q9UHI6

0.63

PPP6R1

22870

Q9UPN7

0.63

DIS3

22894

Q9Y2L1

0.63

RAB18

22931

Q9NP72

0.63

PLCH1

23007

Q4KWH8

0.63

MON2

23041

Q7Z3U7

0.63

PDXDC1

23042

Q6P996

0.63

NCDN

23154

Q9UBB6

0.63

FAF2

23197

Q96CS3

0.63

XPO6

23214

Q96QU8

0.63

NBEAL2

23218

Q6ZNJ1

0.63

VPS13A

23230

Q96RL7

0.63

EXOC6B

23233

Q9Y2D4

0.63

PDS5A

23244

Q29RF7

0.63

SCFD1

23256

Q8WVM8

0.63

UBR4

23352

Q5T4S7

0.63

UFL1

23376

O94874

0.63

ECM29

23392

Q5VYK3

0.63

NCAPH

23397

Q15003

0.63

PLD3

23646

Q8IV08

0.63

TRIM29

23650

Q14134

0.63

SDF2L1

23753

Q9HCN8

0.63

IFIT5

24138

Q13325

0.63

SAMM50

25813

Q9Y512

0.63

COG4

25839

Q9H9E3

0.63

MPC2

25874

O95563

0.63

SAMHD1

25939

Q9Y3Z3

0.63

FAM98A

25940

Q8NCA5

0.63

DHRS7B

25979

Q6IAN0

0.63

LTN1

26046

O94822

0.63

POLDIP2

26073

Q9Y2S7

0.63

TOR1AIP1

26092

Q5JTV8

0.63

PHGDH

26227

O43175

0.63

MYCBP

26292

Q99417

0.63

CKAP2

26586

Q8WWK9

0.63

AP3M1

26985

Q9Y2T2

0.63

TRMT2A

27037

Q8IZ69

0.63

TRAPPC3

27095

O43617

0.63

DIMT1

27292

Q9UNQ2

0.63

EIF3K

27335

Q9UBQ5

0.63

UBE2S

27338

Q16763

0.63

TMEM97

27346

Q5BJF2

0.63

BZW2

28969

Q9Y6E2

0.63

AAMDC

28971

Q9H7C9

0.63

TBK1

29110

Q9UHD2

0.63

NCAPH2

29781

Q6IBW4

0.63

HOOK2

29911

Q96ED9

0.63

PYCR2

29920

Q96C36

0.63

CERS2

29956

Q96G23

0.63

TNPO2

30000

O14787

0.63

EHD4

30844

Q9H223

0.63

GEMIN4

50628

P57678

0.63

DYNC1LI1

51143

Q9Y6G9

0.63

HSD17B12

51144

Q53GQ0

0.63

MRTO4

51154

Q9UKD2

0.63

DBR1

51163

Q9UK59

0.63

DDX47

51202

Q9H0S4

0.63

THEM6

51337

Q8WUY1

0.63

LIMA1

51474

Q9UHB6

0.63

LSR

51599

Q86X29

0.63

STK26

51765

Q9P289

0.63

PELO

53918

Q9BRX2

0.63

YBEY

54059

P58557

0.63

CPVL

54504

Q9H3G5

0.63

EXOC6

54536

Q8TAG9

0.63

DNAJB12

54788

Q9NXW2

0.63

TOR4A

54863

Q9NXH8

0.63

NSUN2

54888

Q08J23

0.63

NCAPG2

54892

Q86XI2

0.63

YTHDF1

54915

Q9BYJ9

0.63

CHCHD3

54927

Q9NX63

0.63

TRMT10C

54931

Q7L0Y3

0.63

HEATR3

55027

Q7Z4Q2

0.63

MRM3

55178

Q9HC36

0.63

RPRD1A

55197

Q96P16

0.63

PANK4

55229

Q9NVE7

0.63

PSPC1

55269

Q8WXF1

0.63

RBM41

55285

Q96IZ5

0.63

LRRC59

55379

Q96AG4

0.63

DDX60

55601

Q8IY21

0.63

TTC27

55622

Q6P3X3

0.63

LRRC40

55631

Q9H9A6

0.63

NSUN5

55695

Q96P11

0.63

VAC14

55697

Q08AM6

0.63

IPO9

55705

Q96P70

0.63

DNAJC11

55735

Q9NVH1

0.63

NGLY1

55768

Q96IV0

0.63

RIOK2

55781

Q9BVS4

0.63

EMC3

55831

Q9P0I2

0.63

LANCL2

55915

Q9NS86

0.63

BCCIP

56647

Q9P287

0.63

TM9SF3

56889

Q9HD45

0.63

PNO1

56902

Q9NRX1

0.63

NCLN

56926

Q969V3

0.63

TOMM22

56993

Q9NS69

0.63

ADCK3

56997

Q8NI60

0.63

CCDC47

57003

Q96A33

0.63

ARFGEF3

57221

Q5TH69

0.63

XPO5

57510

Q9HAV4

0.63

COG6

57511

Q9Y2V7

0.63

KIAA1524

57650

Q8TCG1

0.63

RNF213

57674

Q63HN8

0.63

CCAR2

57805

Q8N163

0.63

SRPRB

58477

Q9Y5M8

0.63

RBM25

58517

P49756

0.63

THADA

63892

Q6YHU6

0.63

NCAPG

64151

Q9BPX3

0.63

XPO4

64328

Q9C0E2

0.63

SUSD1

64420

Q6UWL2

0.63

ENGASE

64772

Q8NFI3

0.63

CDCP1

64866

Q9H5V8

0.63

NT5DC2

64943

Q9H857

0.63

MRPL9

65005

Q9BYD2

0.63

RAPH1

65059

Q70E73

0.63

GGCT

79017

O75223

0.63

CARS2

79587

Q9HA77

0.63

FN3KRP

79672

Q9HA64

0.63

IPO4

79711

Q8TEX9

0.63

GEMIN6

79833

Q8WXD5

0.63

NUP85

79902

Q9BW27

0.63

TTI2

80185

Q6NXR4

0.63

TARS2

80222

Q9BW92

0.63

WDR26

80232

Q9H7D7

0.63

PUS1

80324

Q9Y606

0.63

TRMT1L

81627

Q7Z2T5

0.63

SFXN3

81855

Q9BWM7

0.63

RIOK1

83732

Q9BRS2

0.63

ITCH

83737

Q96J02

0.63

ATAD3B

83858

Q5T9A4

0.63

UTP15

84135

Q8TED0

0.63

FAR1

84188

Q8WVX9

0.63

NTPCR

84284

Q9BSD7

0.63

CMSS1

84319

Q9BQ75

0.63

ATAD1

84896

Q8NBU5

0.63

SERAC1

84947

Q96JX3

0.63

SLFN11

91607

Q7Z7L1

0.63

COG7

91949

P83436

0.63

ARMC6

93436

Q6NXE6

0.63

SAAL1

113174

Q96ER3

0.63

LARP4

113251

Q71RC2

0.63

HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4A; HIST2H4B; HIST4H4

121504

P62805

0.63

ANKRD13B

124930

Q86YJ7

0.63

MRPL10

124995

Q7Z7H8

0.63

TRAPPC5

126003

Q8IUR0

0.63

IQGAP3

128239

Q86VI3

0.63

MTCO2P1

140909

N/A

0.63

C11orf84

144097

Q9BUA3

0.63

CCDC50

152137

Q8IVM0

0.63

SLC39A11

201266

Q8N1S5

0.63

ANO5

203859

Q75V66

0.63

HIST1H2AA

221613

Q96QV6

0.63

LRWD1

222229

Q9UFC0

0.63

PTRF

284119

Q6NZI2

0.63

ODF3L2

284451

Q3SX64

0.63

NLRP10

338322

Q86W26

0.63

ANKRD13D

338692

Q6ZTN6

0.63

GSTK1

373156

Q9Y2Q3

0.63

C6orf120

387263

Q7Z4R8

0.63

MINOS1

440574

Q5TGZ0

0.63

RPS26P11

441502

Q5JNZ5

0.63

ATXN7L3B

552889

Q96GX2

0.63

KCTD9P2

643535

N/A

0.63

TIMM23

100287932

O14925

0.63

KRT86

100293351

O43790

0.63

Q59G22_HUMAN

N/A

Q59G22

0.63

ACTA1

58

P68133

0.65

ERCC1

2067

P07992

0.65

PIK3C2A

5286

O00443

0.65

S100A7

6278

P31151

0.65

PKM

5315

P14618

0.68

PTPRC

5788

P08575

0.68

TRPV1

7442

Q8NER1

0.68

SMURF2

64750

Q9HAU4

0.68

ADRBK1

156

P25098

0.69

IQGAP1

8826

P46940

0.70

ATIC

471

P31939

0.72

EEF1G

1937

P26641

0.72

MEGF6

1953

O75095

0.72

FKBP4

2288

Q02790

0.72

GOT1

2805

P17174

0.72

DNAJC4

3338

Q9NNZ3

0.72

ROR1

4919

Q01973

0.72

PIN4

5303

Q9Y237

0.72

PPP5C

5536

P53041

0.72

PRKAR1B

5575

P31321

0.72

PSMD4

5710

P55036

0.72

PTGDS

5730

P41222

0.72

RAB3A

5864

P20336

0.72

RAP1GDS1

5910

P52306

0.72

SEPP1

6414

P49908

0.72

AURKA

6790

O14965

0.72

CNTN2

6900

Q02246

0.72

AIP

9049

O00170

0.72

MATR3

9782

P43243

0.72

SPCS2

9789

Q15005

0.72

OLFM1

10439

Q99784

0.72

DCTN2

10540

Q13561

0.72

CEND1

51286

Q8N111

0.72

TMCO3

55002

Q6UWJ1

0.72

MGARP

84709

Q8TDB4

0.72

AP1G1

164

O43747

0.73

ALCAM

214

Q13740

0.73

ARL1

400

P40616

0.73

ATP1B1

481

P05026

0.73

CD44

960

P16070

0.73

AP1S1

1174

P61966

0.73

CLTA

1211

P09496

0.73

HBEGF

1839

Q99075

0.73

HOXC10

3226

Q9NYD6

0.73

IARS

3376

P41252

0.73

ICAM1

3383

P05362

0.73

LGALS1

3956

P09382

0.73

PFKL

5211

P17858

0.73

PFKP

5214

Q01813

0.73

PON2

5445

Q15165

0.73

PRKDC

5591

P78527

0.73

RPN1

6184

P04843

0.73

S100A9

6280

P06702

0.73

SEC13

6396

P55735

0.73

CLTCL1

8218

P53675

0.73

RBM10

8241

P98175

0.73

EIF2B2

8892

P49770

0.73

EIF2B5

8893

Q13144

0.73

AP1M1

8907

Q9BXS5

0.73

RIN1

9610

Q13671

0.73

NUP93

9688

Q8N1F7

0.73

RUBCN

9711

Q92622

0.73

BCLAF1

9774

Q9NYF8

0.73

SPTLC1

10558

O15269

0.73

SMC2

10592

O95347

0.73

XPO7

23039

Q9UIA9

0.73

TNPO3

23534

Q9Y5L0

0.73

ACOT9

23597

Q9Y305

0.73

FBXO6

26270

Q9NRD1

0.73

IPO11

51194

Q9UI26

0.73

ATP6V1H

51606

Q9UI12

0.73

DNAAF5

54919

Q86Y56

0.73

LAPTM4B

55353

Q86VI4

0.73

MMS19

64210

Q96T76

0.73

TUBB6

84617

Q9BUF5

0.73

ANKRD13A

88455

Q8IZ07

0.73

TIMM50

92609

Q3ZCQ8

0.73

PLD2

5338

O14939

0.74

EPN1

29924

Q9Y6I3

0.74

EMD

2010

P50402

0.75

NCAM1

4684

P13591

0.75

SEC61A1

29927

P61619

0.75

USP8

9101

P40818

0.76

AKAP12

9590

Q02952

0.76

STIP1

10963

P31948

0.76

MAST1

22983

Q9Y2H9

0.76

RABGEF1

27342

Q9UJ41

0.77

SH3BGRL3

83442

Q9H299

0.77

MAP3K12

7786

Q12852

0.78

SCAMP3

10067

O14828

0.78

CDC25A

993

P30304

0.79

CYTH2

9266

Q99418

0.79

AP1B1

162

Q10567

0.82

ATP5A1

498

P25705

0.82

CANX

821

P27824

0.82

CDH5

1003

P33151

0.82

CFL1

1072

P23528

0.82

AP2S1

1175

P53680

0.82

CSE1L

1434

P55060

0.82

EEF1A1

1915

P68104

0.82

HSPA2

3306

P54652

0.82

IGF1R

3480

P08069

0.82

SLC25A3

5250

Q00325

0.82

PTPRF

5792

P10586

0.82

PEX19

5824

P40855

0.82

SGPL1

8879

O95470

0.82

H1FX

8971

Q92522

0.82

TBRG4

9238

Q969Z0

0.82

SOCS5

9655

O75159

0.82

ILVBL

10994

A1L0T0

0.82

EXOC3

11336

O60645

0.82

XRN2

22803

Q9H0D6

0.82

PHLDA1

22822

Q8WV24

0.82

ATXN10

25814

Q9UBB4

0.82

ARMC8

25852

Q8IUR7

0.82

DNAJB11

51726

Q9UBS4

0.82

EXOC4

60412

Q96A65

0.82

EXOC8

149371

Q8IYI6

0.82

TUBB

203068

P07437

0.82

AP2A2

161

O94973

0.83

AP2B1

163

P63010

0.83

ATP1A1

476

P05023

0.83

EPHA2

1969

P29317

0.83

DNAJA1

3301

P31689

0.83

HSPB1

3315

P04792

0.83

KPNB1

3837

Q14974

0.83

LGALS3

3958

P17931

0.83

YES1

7525

P07947

0.83

EIF2B3

8891

Q9NR50

0.83

DNAJA3

9093

Q96EY1

0.83

XPOT

11260

O43592

0.83

EXOC7

23265

Q9UPT5

0.83

CTNNA1

1495

P35221

0.84

RGS16

6004

O15492

0.84

MET

4233

P08581

0.85

EZR

7430

P15311

0.85

APP

351

P05067

0.86

AR

367

P10275

0.86

ARF6

382

P62330

0.86

ARRB2

409

P32121

0.86

ITGB2

3689

P05107

0.86

ITK

3702

Q08881

0.86

LRP1

4035

Q07954

0.86

MAPT

4137

P10636

0.86

MAP3K3

4215

Q99759

0.86

NTRK2

4915

Q16620

0.86

PIM1

5292

P11309

0.86

PRKCE

5581

Q02156

0.86

PRKCZ

5590

Q05513

0.86

MAPK9

5601

P45984

0.86

RAF1

5894

P04049

0.86

RET

5979

P07949

0.86

RGS4

5999

P49798

0.86

SH3GL3

6457

Q99963

0.86

STAT2

6773

P52630

0.86

TNFRSF1A

7132

P19438

0.86

HSP90B1

7184

P14625

0.86

YWHAB

7529

P31946

0.86

ARHGEF7

8874

Q14155

0.86

WASL

8976

O00401

0.86

HGS

9146

O14964

0.86

SOCS6

9306

O14544

0.86

SH2D3C

10044

Q8N5H7

0.86

WASF3

10810

Q9UPY6

0.86

PTPN18

26469

Q99952

0.86

ITSN2

50618

Q9NZM3

0.86

SNX9

51429

Q9Y5X1

0.86

HDAC7

51564

Q8WUI4

0.86

STAP2

55620

Q9UGK3

0.86

SLA2

84174

Q9H6Q3

0.86

AP2A1

160

O95782

0.87

ATP2A2

488

P16615

0.87

HCK

3055

P08631

0.87

HNRNPH1

3187

P31943

0.87

HSPA5

3309

P11021

0.87

HSPA9

3313

P38646

0.87

SH3BGRL

6451

O75368

0.87

STAT5B

6777

P51692

0.87

VAV2

7410

P52735

0.87

STAM2

10254

O75886

0.87

DNAJA2

10294

O60884

0.87

CDC37

11140

Q16543

0.87

SH3KBP1

30011

Q96B97

0.87

UBASH3B

84959

Q8TF42

0.87

ACTN4

81

O43707

0.88

AKT1

207

P31749

0.88

AREG

374

P15514

0.88

ARRB1

408

P49407

0.88

CDC25C

995

P30307

0.88

DCN

1634

P07585

0.88

DOK1

1796

Q99704

0.88

ERBB4

2066

Q15303

0.88

FGR

2268

P09769

0.88

FRK

2444

P42685

0.88

RAPGEF1

2889

Q13905

0.88

NR3C1

2908

P04150

0.88

LCP2

3937

Q13094

0.88

PAK1

5058

Q13153

0.88

PDGFRA

5156

P16234

0.88

MAPK8

5599

P45983

0.88

S100A4

6275

P26447

0.88

SLC3A2

6520

P08195

0.88

SNCA

6622

P37840

0.88

TUBA4A

7277

P68366

0.88

IKBKG

8517

Q9Y6K9

0.88

GRAP2

9402

O75791

0.88

PTPN22

26191

Q9Y2R2

0.88

LAT

27040

O43561

0.88

TNS3

64759

Q68CZ2

0.88

SHC4

399694

Q6S5L8

0.88

AP2M1

1173

Q96CW1

0.89

CRKL

1399

P46109

0.89

CTTN

2017

Q14247

0.89

NRG1

3084

Q02297

0.89

RASA1

5921

P20936

0.89

TXN

7295

P10599

0.89

TAB1

10454

Q15750

0.89

BAIAP2

10458

Q9UQB8

0.89

CALM2

805

P62158

0.90

CALM3

808

P62158

0.90

CAV1

857

Q03135

0.90

CAV2

858

P51636

0.90

CBL

867

P22681

0.90

CDK1

983

P06493

0.90

CRK

1398

P46108

0.90

CSK

1445

P41240

0.90

CTNNB1

1499

P35222

0.90

CTNND1

1500

O60716

0.90

EGFR

1956

P00533

0.90

ERBB2

2064

P04626

0.90

GAB1

2549

Q13480

0.90

GAPDH

2597

P04406

0.90

SFN

2810

P31947

0.90

HSPA1A

3303

P0DMV8

0.90

HSPA1B

3304

P0DMV9

0.90

HSPA8

3312

P11142

0.90

HSP90AA1

3320

P07900

0.90

HSP90AB1

3326

P08238

0.90

JUP

3728

P14923

0.90

LYN

4067

P07948

0.90

MUC1

4582

P15941

0.90

PIK3R2

5296

O00459

0.90

PLCG1

5335

P19174

0.90

PTPN12

5782

Q05209

0.90

SH3GL2

6456

Q99962

0.90

STAT1

6772

P42224

0.90

STAT3

6774

P40763

0.90

TRAF2

7186

Q12933

0.90

TUBA1A

7846

Q71U36

0.90

HDAC6

10013

Q9UBN7

0.90

YWHAQ

10971

P27348

0.90

EPS15

2060

P42566

0.95

EGF

1950

P01133

0.97

GRB2

2885

P62993

0.97

PTPN1

5770

P18031

0.99

CALU

813

O43852

0.49

CYLC2

1539

Q14093

0.49

STX17

55014

P56962

0.49

HEMGN

55363

Q9BXL5

0.49

AOPEP

84909

Q8N6M6

0.49

SOCS4

122809

Q8WXH5

0.49

TSTD2

158427

Q5T7W7

0.49

AGTR1

185

P30556

0.52

AMH

268

P03971

0.52

GNAI2

2771

P04899

0.52

PRKCB

5579

P05771

0.52

PTPRS

5802

Q13332

0.52

HIST1H3A

8350

P68431

0.52

CAPN7

23473

Q9Y6W3

0.52

FBXO25

26260

Q8TCJ0

0.52

VPS33B

26276

Q9H267

0.52

SOCS7

30837

O14512

0.52

ZFYVE28

57732

Q9HCC9

0.52

RBSN

64145

Q9H1K0

0.52

CEACAM1

634

P13688

0.55

GRB7

2886

Q14451

0.55

TNC

3371

P24821

0.55

ITGA5

3678

P08648

0.55

KRT7

3855

P08729

0.55

KRT8

3856

P05787

0.55

KRT18

3875

P05783

0.55

PITPNA

5306

Q00169

0.55

EPPK1

83481

P58107

0.55

NEDD4

4734

P46934

0.59

CAMK2A

815

Q9UQM7

0.62

CAMK2G

818

Q13555

0.62

LAMP1

3916

P11279

0.62

PRKCD

5580

Q05655

0.62

ZPR1

8882

O75312

0.62

APBB1

322

O00213

0.63

BIRC2

329

Q13490

0.63

BIRC3

330

Q13489

0.63

AXL

558

P30530

0.63

BMX

660

P51813

0.63

FES

2242

P07332

0.63

GSN

2934

P06396

0.63

H2AFX

3014

P16104

0.63

IRS1

3667

P35568

0.63

KPNA1

3836

P52294

0.63

SH2D1A

4068

O60880

0.63

NTRK1

4914

P04629

0.63

PARK2

5071

O60260

0.63

PPP2R3A

5523

Q06190

0.63

PTCH1

5727

Q13635

0.63

PTPRK

5796

Q15262

0.63

ROS1

6098

P08922

0.63

RPA1

6117

P27694

0.63

RPA2

6118

P15927

0.63

RPA3

6119

P35244

0.63

SYK

6850

P43405

0.63

TLN1

7094

Q9Y490

0.63

TLR4

7099

O00206

0.63

TPT1

7178

P13693

0.63

NUMB

8650

P49757

0.63

SH2D2A

9047

Q9NP31

0.63

USP2

9099

O75604

0.63

NUMBL

9253

Q9Y6R0

0.63

MAPK8IP1

9479

Q9UQF2

0.63

APBA3

9546

O96018

0.63

ARHGAP32

9743

A7KAX9

0.63

SH2B3

10019

Q9UQQ2

0.63

ARPC5

10092

O15511

0.63

APBB3

10307

O95704

0.63

RACK1

10399

P63244

0.63

YAP1

10413

P46937

0.63

CD2AP

23607

Q9Y5K6

0.63

SHC2

25759

P98077

0.63

PTPN23

25930

Q9H3S7

0.63

CHD5

26038

Q8TDI0

0.63

APPL1

26060

Q9UKG1

0.63

CHMP4A

29082

Q9BY43

0.63

RIN2

54453

Q8WYP3

0.63

NDFIP2

54602

Q9NV92

0.63

KCTD9

54793

Q7L273

0.63

DOK4

55715

Q8TEW6

0.63

EXOC2

55770

Q96KP1

0.63

DOK5

55816

Q9P104

0.63

PAG1

55824

Q9NWQ8

0.63

ANKS1B

56899

Q7Z6G8

0.63

OTUD7B

56957

Q6GQQ9

0.63

PNPLA2

57104

Q96AD5

0.63

AKTIP

64400

Q9H8T0

0.63

DERL1

79139

Q9BUN8

0.63

SH3D21

79729

A4FU49

0.63

NDFIP1

80762

Q9BT67

0.63

MAP1LC3A

84557

Q9H492

0.63

TMEM25

84866

Q86YD3

0.63

TNS4

84951

Q8IZW8

0.63

CLNK

116449

Q7Z7G1

0.63

DOK6

220164

Q6PKX4

0.63

CD59

966

P13987

0.65

DUSP3

1845

P51452

0.65

PCNA

5111

P12004

0.65

PPARG

5468

P37231

0.65

PTPN2

5771

P17706

0.65

KEAP1

9817

Q14145

0.65

RNF115

27246

Q9Y4L5

0.65

RNF126

55658

Q9BV68

0.65

DEGS1

8560

O15121

0.67

PTPRB

5787

P23467

0.68

RQCD1

9125

Q92600

0.68

CASP1

834

P29466

0.69

PML

5371

P29590

0.70

ALDOA

226

P04075

0.72

CBR1

873

P16152

0.72

COL9A3

1299

Q14050

0.72

CSRP1

1465

P21291

0.72

DYNC1H1

1778

Q14204

0.72

FAH

2184

P16930

0.72

FN1

2335

P02751

0.72

GPM6B

2824

Q13491

0.72

MDH1

4190

P40925

0.72

NDN

4692

Q99608

0.72

OAZ1

4946

P54368

0.72

PDK3

5165

Q15120

0.72

PRCC

5546

Q92733

0.72

PSMA7

5688

O14818

0.72

SLC5A1

6523

P13866

0.72

TPI1

7167

P60174

0.72

UBE2V2

7336

Q15819

0.72

UROD

7389

P06132

0.72

WAS

7454

P42768

0.72

SORBS2

8470

O94875

0.72

RUSC2

9853

Q8N2Y8

0.72

AHSA1

10598

O95433

0.72

HEXIM1

10614

O94992

0.72

ADRM1

11047

Q16186

0.72

MOB4

25843

Q9Y3A3

0.72

LRRK1

79705

Q38SD2

0.72

LRSAM1

90678

Q6UWE0

0.72

EREG

2069

O14944

0.73

HTT

3064

P42858

0.73

PRKAR1A

5573

P10644

0.73

TJP1

7082

Q07157

0.73

SOCS1

8651

O15524

0.73

BECN1

8678

Q14457

0.73

SNX4

8723

O95219

0.73

RIPK1

8737

Q13546

0.73

MAP3K14

9020

Q99558

0.73

GAB2

9846

Q9UQC2

0.73

UBASH3A

53347

P57075

0.73

CEBPB

1051

P17676

0.74

CD82

3732

P27701

0.74

LRIG1

26018

Q96JA1

0.74

SNX6

58533

Q9UNH7

0.74

CMTM8

152189

Q8IZV2

0.74

BTC

685

P35070

0.75

MAPK14

1432

Q16539

0.75

SEC61B

10952

P60468

0.75

GABARAPL2

11345

P60520

0.75

GRB14

2888

Q14449

0.76

UCHL1

7345

P09936

0.76

ARF4

378

P18085

0.77

KRT17

3872

Q04695

0.77

MT-CO2

4513

P00403

0.77

SNRPD2

6633

P62316

0.77

TOM1L1

10040

O75674

0.77

FKBP8

23770

Q14318

0.78

CAV3

859

P56539

0.79

ATP5C1

509

P36542

0.82

IRS4

8471

O14654

0.82

DOK2

9046

O60496

0.82

FER

2241

P16591

0.83

PDGFRB

5159

P09619

0.83

INPPL1

3636

O15357

0.84

PRKACA

5566

P17612

0.84

SNX2

6643

O60749

0.84

VAV3

10451

Q9UKW4

0.84

TNK2

10188

Q07912

0.85

PLSCR1

5359

O15162

0.86

PTK6

5753

Q13882

0.86

SNX1

6642

Q13596

0.86

SHC3

53358

Q92529

0.86

AHNAK

79026

Q09666

0.86

PRDX1

5052

Q06830

0.87

ANXA1

301

P04083

0.88

ESR1

2099

P03372

0.88

PTK2B

2185

Q14289

0.88

JAK2

3717

O60674

0.88

PTPN6

5777

P29350

0.88

VAPA

9218

Q9P0L0

0.88

MAP4K1

11184

Q92918

0.88

ABL1

25

P00519

0.89

ABL2

27

P42684

0.89

APBB2

323

Q92870

0.89

BLK

640

P51451

0.89

CBLB

868

Q13191

0.89

CISH

1154

Q9NSE2

0.89

HSPA4

3308

P34932

0.89

PIK3R1

5295

P27986

0.89

PTPRJ

5795

Q12913

0.89

SLA

6503

Q13239

0.89

TLR2

7097

O60603

0.89

ZAP70

7535

P43403

0.89

PIK3R3

8503

Q92569

0.89

MAPK8IP2

23542

Q13387

0.89

SH2B1

25970

Q9NRF2

0.89

CDH1

999

P12830

0.90

EPS8

2059

Q12929

0.90

ERBB3

2065

P21860

0.90

GRB10

2887

Q13322

0.90

NCK1

4690

P16333

0.90

PIK3C2B

5287

O00750

0.90

PLCG2

5336

P16885

0.90

PRKCA

5578

P17252

0.90

PTK2

5747

Q05397

0.90

PTPN11

5781

Q06124

0.90

SOS2

6655

Q07890

0.90

STAT5A

6776

P42229

0.90

TGFA

7039

P01135

0.90

VAV1

7409

P15498

0.90

YWHAZ

7534

P63104

0.90

NCK2

8440

O43639

0.90

SOCS3

9021

O14543

0.90

PDCD6IP

10015

Q8WUM4

0.90

SH2D3A

10045

Q9BRG2

0.90

STUB1

10273

Q9UNE7

0.90

ANKS1A

23294

Q92625

0.90

CBLC

23624

Q9ULV8

0.90

ERRFI1

54206

Q9UJM3

0.90

CAMLG

819

P49069

0.96

SOS1

6654

Q07889

0.96

SHC1

6464

P29353

0.97

SRC

6714

P12931

0.97