| Gene Symbol | STARD4 |
| Entrez ID | 134429 |
| Uniprot ID | Q96DR4 |
| Description | StAR related lipid transfer domain containing 4 |
| Chromosomal Location | chr5: 111,496,033-111,512,590 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0010873 | positive regulation of cholesterol esterification |
Any process that increases the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle. | IDA |
BP | GO:0010879 | cholesterol transport involved in cholesterol storage |
The directed movement of cholesterol into cells that is part of their accumulation and maintenance. | IDA |
BP | GO:0032367 | intracellular cholesterol transport |
The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells. | IDA |
BP | GO:0070508 | cholesterol import |
The directed movement of cholesterol into a cell or organelle. | IDA |
BP | GO:0070859 | positive regulation of bile acid biosynthetic process |
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. | IDA |
CC | GO:0005739 | mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. | IBA |
CC | GO:0016023 | cytoplasmic, membrane-bounded vesicle |
A membrane-bounded vesicle found in the cytoplasm of the cell. | IDA |
MF | GO:0015485 | cholesterol binding |
Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. | IDA |
MF | GO:0017127 | cholesterol transporter activity |
Enables the directed movement of cholesterol into, out of or within a cell, or between cells. Cholesterol is the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. | IDA |
| Domain ID | Description |
|---|---|
IPR002913 | START domain |
IPR023393 | START-like domain |
| Tissue | Cell Type |
|---|---|
gallbladder | glandular cells |
heart muscle | myocytes |
ovary | follicle cells |
skeletal muscle | myocytes |
smooth muscle | smooth muscle cells |
testis | Leydig cells |
thyroid gland | glandular cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
22617121 | Ouandaogo et al. | 2012 | Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |