Protein Description

Gene Symbol STARD4
Entrez ID 134429
Uniprot ID Q96DR4
Description StAR related lipid transfer domain containing 4
Chromosomal Location chr5: 111,496,033-111,512,590
Ontology GO ID GO Term Definition Evidence

BP

GO:0010873

positive regulation of cholesterol esterification

Any process that increases the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle.

IDA

BP

GO:0010879

cholesterol transport involved in cholesterol storage

The directed movement of cholesterol into cells that is part of their accumulation and maintenance.

IDA

BP

GO:0032367

intracellular cholesterol transport

The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells.

IDA

BP

GO:0070508

cholesterol import

The directed movement of cholesterol into a cell or organelle.

IDA

BP

GO:0070859

positive regulation of bile acid biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.

IDA

CC

GO:0005739

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

IBA

CC

GO:0016023

cytoplasmic, membrane-bounded vesicle

A membrane-bounded vesicle found in the cytoplasm of the cell.

IDA

MF

GO:0015485

cholesterol binding

Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.

IDA

MF

GO:0017127

cholesterol transporter activity

Enables the directed movement of cholesterol into, out of or within a cell, or between cells. Cholesterol is the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.

IDA

Domain ID Description

IPR002913

START domain

IPR023393

START-like domain

No pathways found.

No diseases found.

Tissue Cell Type

gallbladder

glandular cells

heart muscle

myocytes

ovary

follicle cells

skeletal muscle

myocytes

smooth muscle

smooth muscle cells

testis

Leydig cells

thyroid gland

glandular cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

No partners found.