| Gene Symbol | EEF1B2 |
| Entrez ID | 1933 |
| Uniprot ID | P24534 |
| Description | eukaryotic translation elongation factor 1 beta 2 |
| Chromosomal Location | chr2: 206,159,585-206,162,928 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006414 |
translational elongation |
The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. |
NAS|TAS |
|
BP |
GO:0045471 |
response to ethanol |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. |
IEA |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
|
CC |
GO:0005783 |
endoplasmic reticulum |
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
IDA |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
|
CC |
GO:0005853 |
eukaryotic translation elongation factor 1 complex |
A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma. |
NAS |
|
MF |
GO:0003746 |
translation elongation factor activity |
Functions in chain elongation during polypeptide synthesis at the ribosome. |
NAS |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
| Domain ID | Description |
|---|---|
|
IPR001326 |
Translation elongation factor EF1B, beta/delta chains, conserved site |
|
IPR010987 |
Glutathione S-transferase, C-terminal-like |
|
IPR014038 |
Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain |
|
IPR014717 |
Translation elongation factor EF1B/ribosomal protein S6 |
|
IPR018940 |
Elongation factor 1 beta central acidic region, eukaryote |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
WP107 |
Translation Factors |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0027627 |
Neoplasm Metastasis |
|
C1458155 |
Mammary Neoplasms |
|
C3714756 |
Intellectual Disability |
| Tissue | Cell Type |
|---|---|
|
appendix |
lymphoid tissue |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
glandular cells |
|
colon |
peripheral nerve/ganglion |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
kidney |
cells in tubules |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
oral mucosa |
squamous epithelial cells |
|
pancreas |
exocrine glandular cells |
|
pancreas |
islets of Langerhans |
|
placenta |
decidual cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skin |
keratinocytes |
|
skin |
Langerhans |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
GTF2F1 |
2962 |
P35269 |
0.49 |
|
RPL7A |
6130 |
P62424 |
0.49 |
|
RPS2 |
6187 |
P15880 |
0.49 |
|
SNRPA |
6626 |
P09012 |
0.49 |
|
TPR |
7175 |
P12270 |
0.49 |
|
UQCRH |
7388 |
P07919 |
0.49 |
|
KMT2D |
8085 |
O14686 |
0.49 |
|
SRSF9 |
8683 |
Q13242 |
0.49 |
|
PLOD3 |
8985 |
O60568 |
0.49 |
|
NUP153 |
9972 |
P49790 |
0.49 |
|
ATL3 |
25923 |
Q6DD88 |
0.49 |
|
STRN4 |
29888 |
Q9NRL3 |
0.49 |
|
UBQLN2 |
29978 |
Q9UHD9 |
0.49 |
|
HES4 |
57801 |
Q9HCC6 |
0.49 |
|
AHNAK |
79026 |
Q09666 |
0.49 |
|
STRIP1 |
85369 |
Q5VSL9 |
0.49 |
|
RPLP0P6 |
220717 |
Q8NHW5 |
0.49 |
|
EEF1B2 |
1933 |
P24534 |
0.55 |
|
APP |
351 |
P05067 |
0.56 |
|
DNAJA1 |
3301 |
P31689 |
0.63 |
|
TFAP2C |
7022 |
Q92754 |
0.63 |
|
ULK2 |
9706 |
Q8IYT8 |
0.63 |
|
EIF4A2 |
1974 |
Q14240 |
0.70 |
|
EEF1D |
1936 |
P29692 |
0.73 |
|
HARS |
3035 |
P12081 |
0.88 |
|
EWSR1 |
2130 |
Q01844 |
0.49 |
|
HSPB1 |
3315 |
P04792 |
0.49 |
|
HSPD1 |
3329 |
P10809 |
0.49 |
|
AKAP8 |
10270 |
O43823 |
0.49 |
|
ACTB |
60 |
P60709 |
0.55 |
|
DRD3 |
1814 |
P35462 |
0.55 |
|
DHRS2 |
10202 |
Q13268 |
0.55 |
|
PPP2R2B |
5521 |
Q00005 |
0.56 |
|
AARS |
16 |
P49588 |
0.63 |
|
ADRB2 |
154 |
P07550 |
0.63 |
|
CD4 |
920 |
P01730 |
0.63 |
|
CSNK1A1 |
1452 |
P48729 |
0.63 |
|
CSNK1E |
1454 |
P49674 |
0.63 |
|
CSNK2A2 |
1459 |
P19784 |
0.63 |
|
EGFR |
1956 |
P00533 |
0.63 |
|
ENO1 |
2023 |
P06733 |
0.63 |
|
EPB41 |
2035 |
P11171 |
0.63 |
|
GH1 |
2688 |
P01241 |
0.63 |
|
HLA-B |
3106 |
P30480 |
0.63 |
|
ITGA4 |
3676 |
P13612 |
0.63 |
|
JUN |
3725 |
P05412 |
0.63 |
|
MCC |
4163 |
P23508 |
0.63 |
|
MCM2 |
4171 |
P49736 |
0.63 |
|
MGMT |
4255 |
P16455 |
0.63 |
|
MOV10 |
4343 |
Q9HCE1 |
0.63 |
|
NPM1 |
4869 |
P06748 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
MAPK13 |
5603 |
O15264 |
0.63 |
|
SUMO2 |
6613 |
P61956 |
0.63 |
|
TIMP1 |
7076 |
P01033 |
0.63 |
|
CUL5 |
8065 |
Q93034 |
0.63 |
|
CUL3 |
8452 |
Q13618 |
0.63 |
|
CUL2 |
8453 |
Q13617 |
0.63 |
|
CUL1 |
8454 |
Q13616 |
0.63 |
|
EED |
8726 |
O75530 |
0.63 |
|
AIM2 |
9447 |
O14862 |
0.63 |
|
ATG5 |
9474 |
Q9H1Y0 |
0.63 |
|
IKBKE |
9641 |
Q14164 |
0.63 |
|
KIAA0101 |
9768 |
Q15004 |
0.63 |
|
CUL7 |
9820 |
Q14999 |
0.63 |
|
HUWE1 |
10075 |
Q7Z6Z7 |
0.63 |
|
EIF1B |
10289 |
O60739 |
0.63 |
|
NXF1 |
10482 |
Q9UBU9 |
0.63 |
|
GABARAP |
11337 |
O95166 |
0.63 |
|
GABARAPL2 |
11345 |
P60520 |
0.63 |
|
SRRM2 |
23524 |
Q9UQ35 |
0.63 |
|
GABARAPL1 |
23710 |
Q9H0R8 |
0.63 |
|
FBXO6 |
26270 |
Q9NRD1 |
0.63 |
|
EEF2K |
29904 |
O00418 |
0.63 |
|
RIOK2 |
55781 |
Q9BVS4 |
0.63 |
|
CAND1 |
55832 |
Q86VP6 |
0.63 |
|
SMURF1 |
57154 |
Q9HCE7 |
0.63 |
|
ACTR6 |
64431 |
Q9GZN1 |
0.63 |
|
MAP1LC3B |
81631 |
Q9GZQ8 |
0.63 |
|
IGSF8 |
93185 |
Q969P0 |
0.63 |
|
EEF1A1 |
1915 |
P68104 |
0.65 |
|
VHL |
7428 |
P40337 |
0.68 |
|
YWHAZ |
7534 |
P63104 |
0.68 |
|
FN1 |
2335 |
P02751 |
0.72 |
|
H2AFX |
3014 |
P16104 |
0.72 |
|
VARS |
7407 |
P26640 |
0.78 |
|
CSNK2A1 |
1457 |
P68400 |
0.82 |
|
VCAM1 |
7412 |
P19320 |
0.82 |
|
EEF1A2 |
1917 |
Q05639 |
0.93 |
|
EEF1G |
1937 |
P26641 |
0.93 |