Protein Description

Gene Symbol FOPNL
Entrez ID 123811
Uniprot ID Q96NB1
Description FGFR1OP N-terminal like
Chromosomal Location chr16: 15,865,720-15,888,625
Ontology GO ID GO Term Definition Evidence

BP

GO:0034453

microtubule anchoring

Any process in which a microtubule is maintained in a specific location in a cell.

IEA

BP

GO:0042384

cilium assembly

The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.

IMP

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005813

centrosome

A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.

IDA

CC

GO:0031514

motile cilium

A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles.

ISS

CC

GO:0034451

centriolar satellite

A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome.

IDA

CC

GO:0036064

ciliary basal body

A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.

ISS

Domain ID Description

IPR006594

LIS1 homology motif

IPR018993

FGFR1 oncogene partner (FOP), N-terminal dimerisation domain

No pathways found.

No diseases found.

Tissue Cell Type

bronchus

respiratory epithelial cells

esophagus

squamous epithelial cells

fallopian tube

glandular cells

heart muscle

myocytes

nasopharynx

respiratory epithelial cells

skeletal muscle

myocytes

skin

keratinocytes

smooth muscle

smooth muscle cells

soft tissue

chondrocytes

tonsil

squamous epithelial cells

vagina

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

17148555

Wood et al.

2007

Molecular Abnormalities in Oocytes from Women with Polycystic Ovary Syndrome Revealed by Microarray Analysis

Gene Symbol Entrez ID Uniprot ID Score

FOPNL

123811

Q96NB1

0.63

PCM1

5108

Q15154

0.75

KIAA0753

9851

Q2KHM9

0.49

CEP162

22832

Q5TB80

0.49

CEP290

80184

O15078

0.49

CEP63

80254

Q96MT8

0.49

CEP128

145508

Q6ZU80

0.49

ELAVL1

1994

Q15717

0.63

CSNK1E

1454

P49674

0.72

DYNLL1

8655

P63167

0.72

FGFR1OP

11116

O95684

0.72

SLAIN2

57606

Q9P270

0.72

CCDC14

64770

Q49A88

0.72

OFD1

8481

O75665

0.82

CEP135

9662

Q66GS9

0.82