PCOSBase

Protein Description

Gene Symbol	ECHS1
Entrez ID	1892
Uniprot ID	P30084
Description	enoyl-CoA hydratase, short chain, 1, mitochondrial
Chromosomal Location	chr10: 133,362,480-133,373,689

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0006635	fatty acid beta-oxidation	A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).	IDA\|IEA\|TAS
CC	GO:0005739	mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.	IDA\|TAS
CC	GO:0005759	mitochondrial matrix	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.	TAS
CC	GO:0070062	extracellular exosome	A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.	IDA
MF	GO:0004300	enoyl-CoA hydratase activity	Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O.	IDA\|TAS
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI

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Domain ID	Description
IPR001753	Crotonase superfamily
IPR014748	Crontonase, C-terminal
IPR018376	Enoyl-CoA hydratase/isomerase, conserved site
IPR029045	ClpP/crotonase-like domain

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Pathway ID	Pathway Term	Pathway Source
hsa00062	Fatty acid elongation	KEGG
hsa00071	Fatty acid degradation	KEGG
hsa00280	Valine, leucine and isoleucine degradation	KEGG
hsa00310	Lysine degradation	KEGG
hsa00380	Tryptophan metabolism	KEGG
hsa00410	beta-Alanine metabolism	KEGG
hsa00640	Propanoate metabolism	KEGG
hsa00650	Butanoate metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG
hsa01212	Fatty acid metabolism	KEGG
WP357	Fatty Acid Biosynthesis	WikiPathways
WP465	Tryptophan metabolism	WikiPathways
WP143	Fatty Acid Beta Oxidation	WikiPathways

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UMLS CUI	UMLS Term
C0023264	Leigh Disease
C0028754	Obesity
C0038356	Stomach Neoplasms

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Tissue	Cell Type
adrenal gland	glandular cells
appendix	glandular cells
appendix	lymphoid tissue
bone marrow	hematopoietic cells
breast	glandular cells
breast	myoepithelial cells
bronchus	respiratory epithelial cells
cerebellum	cells in granular layer
cerebellum	Purkinje cells
cerebral cortex	glial cells
colon	glandular cells
colon	peripheral nerve/ganglion
duodenum	glandular cells
endometrium	glandular cells
epididymis	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
gallbladder	glandular cells
heart muscle	myocytes
kidney	cells in tubules
liver	hepatocytes
lung	macrophages
nasopharynx	respiratory epithelial cells
pancreas	exocrine glandular cells
placenta	trophoblastic cells
prostate	glandular cells
rectum	glandular cells
salivary gland	glandular cells
seminal vesicle	glandular cells
skin	fibroblasts
small intestine	glandular cells
soft tissue	adipocytes
spleen	cells in white pulp
stomach	glandular cells
testis	cells in seminiferous ducts
testis	Leydig cells
thyroid gland	glandular cells
tonsil	germinal center cells
tonsil	non-germinal center cells
urinary bladder	urothelial cells
vagina	squamous epithelial cells

No databases found.

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Pubmed ID	Author	Year	Title
18765015	Qiao et al.	2008	Microarray evaluation of endometrial receptivity in Chinese women with polycystic ovary syndrome

Gene Symbol	Entrez ID	Uniprot ID	Score
ALDOA	226	P04075	0.49
CTBP1	1487	Q13363	0.49
PCBP1	5093	Q15365	0.49
TALDO1	6888	P37837	0.49
AKR1A1	10327	P14550	0.49
AHCYL1	10768	O43865	0.49
ADI1	55256	Q9BV57	0.49
CAMK2D	817	Q13557	0.63
CAMK2G	818	Q13555	0.63
CYP2E1	1571	P05181	0.63
DBT	1629	P11182	0.63
PPM1B	5495	O75688	0.63
RAP1GDS1	5910	P52306	0.63
TFE3	7030	P19532	0.63
TGM2	7052	P21980	0.63
UBA1	7317	P22314	0.63
HERC1	8925	Q15751	0.63
CLDN12	9069	P56749	0.63
SLC9A3R1	9368	O14745	0.63
USP15	9958	Q9Y4E8	0.63
YWHAQ	10971	P27348	0.63
ABHD14A	25864	Q9BUJ0	0.63
CNDP2	55748	Q96KP4	0.63
PPP4R3B	57223	Q5MIZ7	0.63
GINS3	64785	Q9BRX5	0.63
LRRK1	79705	Q38SD2	0.63
ATPAF2	91647	Q8N5M1	0.63
CBWD2	150472	Q8IUF1	0.63
UBE2V1	387522	Q13404	0.63
ECHS1	1892	P30084	0.7
LRRK2	120892	Q5S007	0.73
STAT3	6774	P40763	0.23
ITPA	3704	Q9BY32	0.49
ABCC1	4363	P33527	0.49
PPIB	5479	P23284	0.49
RAP1A	5906	P62834	0.49
SUMO3	6612	P55854	0.49
TPD52L2	7165	O43399	0.49
RAB11FIP5	26056	Q9BXF6	0.49
ISYNA1	51477	Q9NPH2	0.49
COX4I1	1327	P13073	0.63
GH1	2688	P01241	0.63
GRB2	2885	P62993	0.63
GSS	2937	P48637	0.63
HLA-B	3106	P30480	0.63
HSPA9	3313	P38646	0.63
MCC	4163	P23508	0.63
MDM2	4193	Q00987	0.63
MOV10	4343	Q9HCE1	0.63
NTRK1	4914	P04629	0.63
PAK2	5062	Q13177	0.63
PFAS	5198	O15067	0.63
SERPINA1	5265	P01009	0.63
PRKAB1	5564	Q9Y478	0.63
SUMO2	6613	P61956	0.63
TIMP2	7077	P16035	0.63
TRAF6	7189	Q9Y4K3	0.63
VCL	7414	P18206	0.63
VHL	7428	P40337	0.63
RIPK2	8767	O43353	0.63
USP14	9097	P54578	0.63
ATG5	9474	Q9H1Y0	0.63
IKBKE	9641	Q14164	0.63
CUL7	9820	Q14999	0.63
EIF1B	10289	O60739	0.63
NXF1	10482	Q9UBU9	0.63
GABARAPL2	11345	P60520	0.63
TNIK	23043	Q9UKE5	0.63
SIRT4	23409	Q9Y6E7	0.63
FTSJ1	24140	Q9UET6	0.63
DCPS	28960	Q96C86	0.63
UCHL5	51377	Q9Y5K5	0.63
SMURF2	64750	Q9HAU4	0.63
FASTKD3	79072	Q14CZ7	0.63
UBA5	79876	Q9GZZ9	0.63
TRIM63	84676	Q969Q1	0.63
BAG6	7917	P46379	0.72
YEATS4	8089	O95619	0.72
SYNCRIP	10492	O60506	0.72
DDA1	79016	Q9BW61	0.72
NEDD1	121441	Q8NHV4	0.72
EPB41	2035	P11171	0.76
CAPN1	823	P07384	0.82
YWHAZ	7534	P63104	0.84