| Gene Symbol | ECHS1 |
| Entrez ID | 1892 |
| Uniprot ID | P30084 |
| Description | enoyl-CoA hydratase, short chain, 1, mitochondrial |
| Chromosomal Location | chr10: 133,362,480-133,373,689 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006635 |
fatty acid beta-oxidation |
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). |
IDA|IEA|TAS |
|
CC |
GO:0005739 |
mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
IDA|TAS |
|
CC |
GO:0005759 |
mitochondrial matrix |
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
TAS |
|
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
|
MF |
GO:0004300 |
enoyl-CoA hydratase activity |
Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O. |
IDA|TAS |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
| Domain ID | Description |
|---|---|
|
IPR001753 |
Crotonase superfamily |
|
IPR014748 |
Crontonase, C-terminal |
|
IPR018376 |
Enoyl-CoA hydratase/isomerase, conserved site |
|
IPR029045 |
ClpP/crotonase-like domain |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00062 |
Fatty acid elongation |
KEGG |
|
hsa00071 |
Fatty acid degradation |
KEGG |
|
hsa00280 |
Valine, leucine and isoleucine degradation |
KEGG |
|
hsa00310 |
Lysine degradation |
KEGG |
|
hsa00380 |
Tryptophan metabolism |
KEGG |
|
hsa00410 |
beta-Alanine metabolism |
KEGG |
|
hsa00640 |
Propanoate metabolism |
KEGG |
|
hsa00650 |
Butanoate metabolism |
KEGG |
|
hsa01100 |
Metabolic pathways |
KEGG |
|
hsa01200 |
Carbon metabolism |
KEGG |
|
hsa01212 |
Fatty acid metabolism |
KEGG |
|
WP357 |
Fatty Acid Biosynthesis |
WikiPathways |
|
WP465 |
Tryptophan metabolism |
WikiPathways |
|
WP143 |
Fatty Acid Beta Oxidation |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0023264 |
Leigh Disease |
|
C0028754 |
Obesity |
|
C0038356 |
Stomach Neoplasms |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
appendix |
lymphoid tissue |
|
bone marrow |
hematopoietic cells |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
bronchus |
respiratory epithelial cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
glial cells |
|
colon |
glandular cells |
|
colon |
peripheral nerve/ganglion |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
kidney |
cells in tubules |
|
liver |
hepatocytes |
|
lung |
macrophages |
|
nasopharynx |
respiratory epithelial cells |
|
pancreas |
exocrine glandular cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skin |
fibroblasts |
|
small intestine |
glandular cells |
|
soft tissue |
adipocytes |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
18765015 |
Qiao et al. |
2008 |
Microarray evaluation of endometrial receptivity in Chinese women with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
ALDOA |
226 |
P04075 |
0.49 |
|
CTBP1 |
1487 |
Q13363 |
0.49 |
|
PCBP1 |
5093 |
Q15365 |
0.49 |
|
TALDO1 |
6888 |
P37837 |
0.49 |
|
AKR1A1 |
10327 |
P14550 |
0.49 |
|
AHCYL1 |
10768 |
O43865 |
0.49 |
|
ADI1 |
55256 |
Q9BV57 |
0.49 |
|
CAMK2D |
817 |
Q13557 |
0.63 |
|
CAMK2G |
818 |
Q13555 |
0.63 |
|
CYP2E1 |
1571 |
P05181 |
0.63 |
|
DBT |
1629 |
P11182 |
0.63 |
|
PPM1B |
5495 |
O75688 |
0.63 |
|
RAP1GDS1 |
5910 |
P52306 |
0.63 |
|
TFE3 |
7030 |
P19532 |
0.63 |
|
TGM2 |
7052 |
P21980 |
0.63 |
|
UBA1 |
7317 |
P22314 |
0.63 |
|
HERC1 |
8925 |
Q15751 |
0.63 |
|
CLDN12 |
9069 |
P56749 |
0.63 |
|
SLC9A3R1 |
9368 |
O14745 |
0.63 |
|
USP15 |
9958 |
Q9Y4E8 |
0.63 |
|
YWHAQ |
10971 |
P27348 |
0.63 |
|
ABHD14A |
25864 |
Q9BUJ0 |
0.63 |
|
CNDP2 |
55748 |
Q96KP4 |
0.63 |
|
PPP4R3B |
57223 |
Q5MIZ7 |
0.63 |
|
GINS3 |
64785 |
Q9BRX5 |
0.63 |
|
LRRK1 |
79705 |
Q38SD2 |
0.63 |
|
ATPAF2 |
91647 |
Q8N5M1 |
0.63 |
|
CBWD2 |
150472 |
Q8IUF1 |
0.63 |
|
UBE2V1 |
387522 |
Q13404 |
0.63 |
|
ECHS1 |
1892 |
P30084 |
0.70 |
|
LRRK2 |
120892 |
Q5S007 |
0.73 |
|
STAT3 |
6774 |
P40763 |
0.23 |
|
ITPA |
3704 |
Q9BY32 |
0.49 |
|
ABCC1 |
4363 |
P33527 |
0.49 |
|
PPIB |
5479 |
P23284 |
0.49 |
|
RAP1A |
5906 |
P62834 |
0.49 |
|
SUMO3 |
6612 |
P55854 |
0.49 |
|
TPD52L2 |
7165 |
O43399 |
0.49 |
|
RAB11FIP5 |
26056 |
Q9BXF6 |
0.49 |
|
ISYNA1 |
51477 |
Q9NPH2 |
0.49 |
|
COX4I1 |
1327 |
P13073 |
0.63 |
|
GH1 |
2688 |
P01241 |
0.63 |
|
GRB2 |
2885 |
P62993 |
0.63 |
|
GSS |
2937 |
P48637 |
0.63 |
|
HLA-B |
3106 |
P30480 |
0.63 |
|
HSPA9 |
3313 |
P38646 |
0.63 |
|
MCC |
4163 |
P23508 |
0.63 |
|
MDM2 |
4193 |
Q00987 |
0.63 |
|
MOV10 |
4343 |
Q9HCE1 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
PAK2 |
5062 |
Q13177 |
0.63 |
|
PFAS |
5198 |
O15067 |
0.63 |
|
SERPINA1 |
5265 |
P01009 |
0.63 |
|
PRKAB1 |
5564 |
Q9Y478 |
0.63 |
|
SUMO2 |
6613 |
P61956 |
0.63 |
|
TIMP2 |
7077 |
P16035 |
0.63 |
|
TRAF6 |
7189 |
Q9Y4K3 |
0.63 |
|
VCL |
7414 |
P18206 |
0.63 |
|
VHL |
7428 |
P40337 |
0.63 |
|
RIPK2 |
8767 |
O43353 |
0.63 |
|
USP14 |
9097 |
P54578 |
0.63 |
|
ATG5 |
9474 |
Q9H1Y0 |
0.63 |
|
IKBKE |
9641 |
Q14164 |
0.63 |
|
CUL7 |
9820 |
Q14999 |
0.63 |
|
EIF1B |
10289 |
O60739 |
0.63 |
|
NXF1 |
10482 |
Q9UBU9 |
0.63 |
|
GABARAPL2 |
11345 |
P60520 |
0.63 |
|
TNIK |
23043 |
Q9UKE5 |
0.63 |
|
SIRT4 |
23409 |
Q9Y6E7 |
0.63 |
|
FTSJ1 |
24140 |
Q9UET6 |
0.63 |
|
DCPS |
28960 |
Q96C86 |
0.63 |
|
UCHL5 |
51377 |
Q9Y5K5 |
0.63 |
|
SMURF2 |
64750 |
Q9HAU4 |
0.63 |
|
FASTKD3 |
79072 |
Q14CZ7 |
0.63 |
|
UBA5 |
79876 |
Q9GZZ9 |
0.63 |
|
TRIM63 |
84676 |
Q969Q1 |
0.63 |
|
BAG6 |
7917 |
P46379 |
0.72 |
|
YEATS4 |
8089 |
O95619 |
0.72 |
|
SYNCRIP |
10492 |
O60506 |
0.72 |
|
DDA1 |
79016 |
Q9BW61 |
0.72 |
|
NEDD1 |
121441 |
Q8NHV4 |
0.72 |
|
EPB41 |
2035 |
P11171 |
0.76 |
|
CAPN1 |
823 |
P07384 |
0.82 |
|
YWHAZ |
7534 |
P63104 |
0.84 |