Protein Description

Gene Symbol TYMP
Entrez ID 1890
Uniprot ID P19971
Description thymidine phosphorylase
Chromosomal Location chr22: 50,525,752-50,530,056
Ontology GO ID GO Term Definition Evidence

BP

GO:0001525

angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

IEA

BP

GO:0006206

pyrimidine nucleobase metabolic process

The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.

IEA

BP

GO:0006935

chemotaxis

The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

IEA

BP

GO:0030154

cell differentiation

The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.

IEA

BP

GO:0043097

pyrimidine nucleoside salvage

Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis.

TAS

BP

GO:0046135

pyrimidine nucleoside catabolic process

The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).

TAS

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

IBA|TAS

MF

GO:0004645

phosphorylase activity

Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase.

IBA

MF

GO:0008083

growth factor activity

The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.

IEA

MF

GO:0009032

thymidine phosphorylase activity

Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate.

IEA

MF

GO:0016154

pyrimidine-nucleoside phosphorylase activity

Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate.

IEA

MF

GO:0016763

transferase activity, transferring pentosyl groups

Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor).

EXP

Domain ID Description

IPR000053

Thymidine/pyrimidine-nucleoside phosphorylase

IPR000312

Glycosyl transferase, family 3

IPR013102

Pyrimidine nucleoside phosphorylase, C-terminal

IPR017459

Glycosyl transferase family 3, N-terminal domain

IPR017872

Pyrimidine-nucleoside phosphorylase, conserved site

IPR018090

Pyrimidine-nucleoside phosphorylase, bacterial/eukaryotic

Pathway ID Pathway Term Pathway Source

hsa00240

Pyrimidine metabolism

KEGG

hsa00983

Drug metabolism - other enzymes

KEGG

hsa01100

Metabolic pathways

KEGG

hsa05219

Bladder cancer

KEGG

WP2828

Bladder Cancer

WikiPathways

WP1601

Fluoropyrimidine Activity

WikiPathways

UMLS CUI UMLS Term

C0005695

Bladder Neoplasm

C0009375

Colonic Neoplasms

C0009404

Colorectal Neoplasms

C0027627

Neoplasm Metastasis

C0030297

Pancreatic Neoplasm

C0038356

Stomach Neoplasms

C1261502

Finding Of Mean Corpuscular Hemoglobin

No tissues found.

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22904171

Kaur et al.

2012

Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

EEF2

1938

P13639

0.63

GAPDH

2597

P04406

0.63

HSP90AA1

3320

P07900

0.63

TYMP

1890

P19971

0.75

DERA

51071

Q9Y315

0.49

EIF4E

1977

P06730

0.63

SUMO2

6613

P61956

0.63

ZSCAN20

7579

P17040

0.63

DDX19B

11269

Q9UMR2

0.63

CCDC94

55702

Q9BW85

0.63

GMCL1

64395

Q96IK5

0.63

NUDCD1

84955

Q96RS6

0.63

SUSD3

203328

Q96L08

0.63

RBM24

221662

Q9BX46

0.63