Gene Symbol | TYMP |
Entrez ID | 1890 |
Uniprot ID | P19971 |
Description | thymidine phosphorylase |
Chromosomal Location | chr22: 50,525,752-50,530,056 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0001525 |
angiogenesis |
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
IEA |
BP |
GO:0006206 |
pyrimidine nucleobase metabolic process |
The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. |
IEA |
BP |
GO:0006935 |
chemotaxis |
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). |
IEA |
BP |
GO:0030154 |
cell differentiation |
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
IEA |
BP |
GO:0043097 |
pyrimidine nucleoside salvage |
Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis. |
TAS |
BP |
GO:0046135 |
pyrimidine nucleoside catabolic process |
The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). |
TAS |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
IBA|TAS |
MF |
GO:0004645 |
phosphorylase activity |
Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase. |
IBA |
MF |
GO:0008083 |
growth factor activity |
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. |
IEA |
MF |
GO:0009032 |
thymidine phosphorylase activity |
Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate. |
IEA |
MF |
GO:0016154 |
pyrimidine-nucleoside phosphorylase activity |
Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate. |
IEA |
MF |
GO:0016763 |
transferase activity, transferring pentosyl groups |
Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). |
EXP |
Domain ID | Description |
---|---|
IPR000053 |
Thymidine/pyrimidine-nucleoside phosphorylase |
IPR000312 |
Glycosyl transferase, family 3 |
IPR013102 |
Pyrimidine nucleoside phosphorylase, C-terminal |
IPR017459 |
Glycosyl transferase family 3, N-terminal domain |
IPR017872 |
Pyrimidine-nucleoside phosphorylase, conserved site |
IPR018090 |
Pyrimidine-nucleoside phosphorylase, bacterial/eukaryotic |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00240 |
Pyrimidine metabolism |
KEGG |
hsa00983 |
Drug metabolism - other enzymes |
KEGG |
hsa01100 |
Metabolic pathways |
KEGG |
hsa05219 |
Bladder cancer |
KEGG |
WP2828 |
Bladder Cancer |
WikiPathways |
WP1601 |
Fluoropyrimidine Activity |
WikiPathways |
UMLS CUI | UMLS Term |
---|---|
C0005695 |
Bladder Neoplasm |
C0009375 |
Colonic Neoplasms |
C0009404 |
Colorectal Neoplasms |
C0027627 |
Neoplasm Metastasis |
C0030297 |
Pancreatic Neoplasm |
C0038356 |
Stomach Neoplasms |
C1261502 |
Finding Of Mean Corpuscular Hemoglobin |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
22904171 |
Kaur et al. |
2012 |
Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis |
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
EEF2 |
1938 |
P13639 |
0.63 |
GAPDH |
2597 |
P04406 |
0.63 |
HSP90AA1 |
3320 |
P07900 |
0.63 |
TYMP |
1890 |
P19971 |
0.75 |
DERA |
51071 |
Q9Y315 |
0.49 |
EIF4E |
1977 |
P06730 |
0.63 |
SUMO2 |
6613 |
P61956 |
0.63 |
ZSCAN20 |
7579 |
P17040 |
0.63 |
DDX19B |
11269 |
Q9UMR2 |
0.63 |
CCDC94 |
55702 |
Q9BW85 |
0.63 |
GMCL1 |
64395 |
Q96IK5 |
0.63 |
NUDCD1 |
84955 |
Q96RS6 |
0.63 |
SUSD3 |
203328 |
Q96L08 |
0.63 |
RBM24 |
221662 |
Q9BX46 |
0.63 |