BP

GO:0002250

adaptive immune response

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).

ISS

BP

GO:0002312

B cell activation involved in immune response

The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

IBA

BP

GO:0002313

mature B cell differentiation involved in immune response

The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response.

ISS

BP

GO:0002407

dendritic cell chemotaxis

The movement of a dendritic cell in response to an external stimulus.

ISS

BP

GO:0006955

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

TAS

BP

GO:0006959

humoral immune response

An immune response mediated through a body fluid.

ISS

BP

GO:0007186

G-protein coupled receptor signaling pathway

A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).

IDA

BP

GO:0010818

T cell chemotaxis

The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.

ISS

BP

GO:0030316

osteoclast differentiation

The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.

ISS

BP

GO:0030595

leukocyte chemotaxis

The movement of a leukocyte in response to an external stimulus.

IMP

BP

GO:0030890

positive regulation of B cell proliferation

Any process that activates or increases the rate or extent of B cell proliferation.

IDA

BP

GO:0036145

dendritic cell homeostasis

The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.

ISS

BP

GO:0061470

T follicular helper cell differentiation

The process in which a relatively unspecialized T cell acquires specialized features of a mature T follicular helper cell.

ISS

BP

GO:0070374

positive regulation of ERK1 and ERK2 cascade

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.

IDA

BP

GO:2000458

regulation of astrocyte chemotaxis

Any process that modulates the frequency, rate or extent of astrocyte chemotaxis.

IDA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA

CC

GO:0005887

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

TAS

MF

GO:0004930

G-protein coupled receptor activity

Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.

IDA

MF

GO:0008142

oxysterol binding

Interacting selectively and non-covalently with oxysterol, an oxidized form of cholesterol.

IDA|IMP