BP

GO:0001558

regulation of cell growth

Any process that modulates the frequency, rate, extent or direction of cell growth.

NAS

BP

GO:0001819

positive regulation of cytokine production

Any process that activates or increases the frequency, rate or extent of production of a cytokine.

TAS

BP

GO:0001822

kidney development

The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.

IMP

BP

GO:0001974

blood vessel remodeling

The reorganization or renovation of existing blood vessels.

TAS

BP

GO:0002003

angiotensin maturation

The process leading to the attainment of the full functional capacity of angiotensin by conversion of renin substrate into mature angiotensin in the blood.

TAS

BP

GO:0002016

regulation of blood volume by renin-angiotensin

The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood.

NAS

BP

GO:0002018

renin-angiotensin regulation of aldosterone production

The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone.

NAS

BP

GO:0002019

regulation of renal output by angiotensin

The process in which angiotensin directly modulates the rate of urine output by the kidney.

NAS

BP

GO:0002027

regulation of heart rate

Any process that modulates the frequency or rate of heart contraction.

IEA

BP

GO:0002034

regulation of blood vessel size by renin-angiotensin

The process in which the diameter of a blood vessel is changed due to activity of the renin-angiotensin system.

TAS

BP

GO:0003014

renal system process

A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila).

IDA

BP

GO:0003051

angiotensin-mediated drinking behavior

The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst.

IEA

BP

GO:0003331

positive regulation of extracellular matrix constituent secretion

Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.

IEA

BP

GO:0006883

cellular sodium ion homeostasis

Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.

IEA

BP

GO:0007166

cell surface receptor signaling pathway

A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.

IEA

BP

GO:0007186

G-protein coupled receptor signaling pathway

A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).

IDA

BP

GO:0007199

G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase (GC) activity and a subsequent increase in the concentration of cyclic GMP (cGMP).

TAS

BP

GO:0007200

phospholipase C-activating G-protein coupled receptor signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).

NAS

BP

GO:0007202

activation of phospholipase C activity

The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.

IEA

BP

GO:0007204

positive regulation of cytosolic calcium ion concentration

Any process that increases the concentration of calcium ions in the cytosol.

IEA

BP

GO:0007263

nitric oxide mediated signal transduction

Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.

TAS

BP

GO:0007267

cell-cell signaling

Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.

TAS

BP

GO:0007565

female pregnancy

The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.

IEA

BP

GO:0007568

aging

A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).

IEA

BP

GO:0008217

regulation of blood pressure

Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.

IGI

BP

GO:0010535

positive regulation of activation of JAK2 kinase activity

Any process that increase the frequency or rate of activation of JAK2 protein. The activation of JAK2 protein is the process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it.

IMP

BP

GO:0010595

positive regulation of endothelial cell migration

Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.

IDA

BP

GO:0010613

positive regulation of cardiac muscle hypertrophy

Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.

ISS

BP

GO:0010666

positive regulation of cardiac muscle cell apoptotic process

Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.

IEA

BP

GO:0010744

positive regulation of macrophage derived foam cell differentiation

Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.

IC

BP

GO:0010873

positive regulation of cholesterol esterification

Any process that increases the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle.

IDA

BP

GO:0010951

negative regulation of endopeptidase activity

Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.

IEA

BP

GO:0014061

regulation of norepinephrine secretion

Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine.

IEA

BP

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.

IDA

BP

GO:0014824

artery smooth muscle contraction

A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the artery. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The artery is a vessel carrying blood away from the heart.

IEA

BP

GO:0014873

response to muscle activity involved in regulation of muscle adaptation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. This process occurs as part of the regulation of muscle adaptation.

ISS

BP

GO:0016525

negative regulation of angiogenesis

Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.

IEA

BP

GO:0019229

regulation of vasoconstriction

Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels.

NAS

BP

GO:0030308

negative regulation of cell growth

Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.

IEA

BP

GO:0032270

positive regulation of cellular protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

IDA

BP

GO:0032930

positive regulation of superoxide anion generation

Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell.

IEA

BP

GO:0033864

positive regulation of NAD(P)H oxidase activity

Any process that activates or increases the activity of the enzyme NAD(P)H oxidase.

TAS

BP

GO:0034104

negative regulation of tissue remodeling

Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling.

IEA

BP

GO:0034374

low-density lipoprotein particle remodeling

The acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL.

NAS

BP

GO:0035411

catenin import into nucleus

The directed movement of a catenin protein from the cytoplasm into the nucleus.

IEA

BP

GO:0035813

regulation of renal sodium excretion

Any process that modulates the amount of sodium excreted in urine over a unit of time.

NAS

BP

GO:0035815

positive regulation of renal sodium excretion

Any process that increases the amount of sodium excreted in urine over a unit of time.

IEA

BP

GO:0042127

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

NAS

BP

GO:0042311

vasodilation

An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure.

IEA

BP

GO:0045429

positive regulation of nitric oxide biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.

IEA

BP

GO:0045742

positive regulation of epidermal growth factor receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.

IDA

BP

GO:0045777

positive regulation of blood pressure

Any process in which the force of blood traveling through the circulatory system is increased.

IEA

BP

GO:0045893

positive regulation of transcription, DNA-templated

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

IDA

BP

GO:0045909

positive regulation of vasodilation

Any process that activates or increases the frequency, rate or extent of vasodilation.

IEA

BP

GO:0048144

fibroblast proliferation

The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population.

IEA

BP

GO:0048146

positive regulation of fibroblast proliferation

Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.

ISS

BP

GO:0048169

regulation of long-term neuronal synaptic plasticity

A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.

IEA

BP

GO:0048659

smooth muscle cell proliferation

The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population.

IEA

BP

GO:0050663

cytokine secretion

The regulated release of cytokines from a cell. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.

IEA

BP

GO:0050729

positive regulation of inflammatory response

Any process that activates or increases the frequency, rate or extent of the inflammatory response.

TAS

BP

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.

IDA

BP

GO:0051092

positive regulation of NF-kappaB transcription factor activity

Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.

TAS

BP

GO:0051387

negative regulation of neurotrophin TRK receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway.

IDA

BP

GO:0051403

stress-activated MAPK cascade

A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase.

IEA

BP

GO:0051924

regulation of calcium ion transport

Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

IEA

BP

GO:0051969

regulation of transmission of nerve impulse

Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.

IEA

BP

GO:0061049

cell growth involved in cardiac muscle cell development

The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.

IEA

BP

GO:0061098

positive regulation of protein tyrosine kinase activity

Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity.

IMP

BP

GO:0070371

ERK1 and ERK2 cascade

An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.

IEA

BP

GO:0070471

uterine smooth muscle contraction

A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the uterus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The uterus is a muscular organ of the female mammal for containing and usually for nourishing the young during development prior to birth.

IEA

BP

GO:0071260

cellular response to mechanical stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.

IEA

BP

GO:0090190

positive regulation of branching involved in ureteric bud morphogenesis

Any process that increases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.

IDA

BP

GO:1901201

regulation of extracellular matrix assembly

Any process that modulates the frequency, rate or extent of extracellular matrix assembly.

IGI

BP

GO:1902828

positive regulation of L-arginine import into cell

Any process that activates or increases the frequency, rate or extent of L-arginine import into cell.

IEA

BP

GO:1903598

positive regulation of gap junction assembly

Any process that activates or increases the frequency, rate or extent of gap junction assembly.

IGI

BP

GO:1903779

regulation of cardiac conduction

Any process that modulates the frequency, rate or extent of cardiac conduction.

IGI

BP

GO:1904707

positive regulation of vascular smooth muscle cell proliferation

Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation.

IEA

BP

GO:1904754

positive regulation of vascular associated smooth muscle cell migration

Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration.

IEA

BP

GO:1905010

positive regulation of L-lysine import into cell

Any process that activates or increases the frequency, rate or extent of L-lysine import into cell.

IEA

BP

GO:2000379

positive regulation of reactive oxygen species metabolic process

Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process.

TAS

BP

GO:2001238

positive regulation of extrinsic apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway.

IDA

BP

GO:2001275

positive regulation of glucose import in response to insulin stimulus

Any process that activates or increases the frequency, rate or extent of glucose import in response to insulin stimulus.

IEA

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

NAS|TAS

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IC|IDA|ISS

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IEA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

CC

GO:0072562

blood microparticle

A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.

IDA

MF

GO:0004867

serine-type endopeptidase inhibitor activity

Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

TAS

MF

GO:0005179

hormone activity

The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.

IC|ISS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0008083

growth factor activity

The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.

TAS

MF

GO:0031702

type 1 angiotensin receptor binding

Interacting selectively and non-covalently with a type 1 angiotensin receptor.

IPI

MF

GO:0031703

type 2 angiotensin receptor binding

Interacting selectively and non-covalently with a type 2 angiotensin receptor.

IPI