Gene Symbol | C12orf65 |
Entrez ID | 91574 |
Uniprot ID | Q9H3J6 |
Description | chromosome 12 open reading frame 65 |
Chromosomal Location | chr12: 123,232,916-123,257,959 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0070126 |
mitochondrial translational termination |
The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa). |
IBA |
BP |
GO:0072344 |
rescue of stalled ribosome |
A process of translational elongation that takes place when a ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex. |
IBA |
CC |
GO:0005739 |
mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
NAS |
CC |
GO:0005762 |
mitochondrial large ribosomal subunit |
The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). |
IBA |
MF |
GO:0004045 |
aminoacyl-tRNA hydrolase activity |
Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. |
IBA |
MF |
GO:0016150 |
translation release factor activity, codon nonspecific |
A translation release factor that is not specific to particular codons; binds to guanine nucleotides. |
IBA |
MF |
GO:0043022 |
ribosome binding |
Interacting selectively and non-covalently with any part of a ribosome. |
IBA |
Domain ID | Description |
---|---|
IPR000352 |
Peptide chain release factor class I/class II |
UMLS CUI | UMLS Term |
---|---|
C0036341 |
Schizophrenia |
C0162666 |
Mitochondrial Encephalomyopathies |
Tissue | Cell Type |
---|---|
colon |
endothelial cells |
placenta |
decidual cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
APP |
351 |
P05067 |
0.56 |
CDK2 |
1017 |
P24941 |
0.63 |
MYLK2 |
85366 |
Q9H1R3 |
0.63 |