Protein Description

Gene Symbol C12orf65
Entrez ID 91574
Uniprot ID Q9H3J6
Description chromosome 12 open reading frame 65
Chromosomal Location chr12: 123,232,916-123,257,959
Ontology GO ID GO Term Definition Evidence

BP

GO:0070126

mitochondrial translational termination

The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa).

IBA

BP

GO:0072344

rescue of stalled ribosome

A process of translational elongation that takes place when a ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex.

IBA

CC

GO:0005739

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

NAS

CC

GO:0005762

mitochondrial large ribosomal subunit

The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).

IBA

MF

GO:0004045

aminoacyl-tRNA hydrolase activity

Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.

IBA

MF

GO:0016150

translation release factor activity, codon nonspecific

A translation release factor that is not specific to particular codons; binds to guanine nucleotides.

IBA

MF

GO:0043022

ribosome binding

Interacting selectively and non-covalently with any part of a ribosome.

IBA

Domain ID Description

IPR000352

Peptide chain release factor class I/class II

No pathways found.

UMLS CUI UMLS Term

C0036341

Schizophrenia

C0162666

Mitochondrial Encephalomyopathies

Tissue Cell Type

colon

endothelial cells

placenta

decidual cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

APP

351

P05067

0.56

CDK2

1017

P24941

0.63

MYLK2

85366

Q9H1R3

0.63