Protein Description

Gene Symbol KLHL13
Entrez ID 90293
Uniprot ID Q9P2N7
Description kelch like family member 13
Chromosomal Location chrX: 117,897,813-118,117,340
Ontology GO ID GO Term Definition Evidence

BP

GO:0000910

cytokinesis

The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.

IMP

BP

GO:0007067

mitotic nuclear division

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

IEA

BP

GO:0016567

protein ubiquitination

The process in which one or more ubiquitin groups are added to a protein.

IDA|IEA

CC

GO:0030496

midbody

A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.

IBA

CC

GO:0031463

Cul3-RING ubiquitin ligase complex

A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.

IDA

MF

GO:0004842

ubiquitin-protein transferase activity

Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.

IDA

Domain ID Description

IPR000210

BTB/POZ domain

IPR006652

Kelch repeat type 1

IPR011333

SKP1/BTB/POZ domain

IPR011705

BTB/Kelch-associated

IPR015915

Kelch-type beta propeller

IPR017096

BTB-kelch protein

Pathway ID Pathway Term Pathway Source

hsa04120

Ubiquitin mediated proteolysis

KEGG

No diseases found.

Tissue Cell Type

smooth muscle

smooth muscle cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

HSP90AB1

3326

P08238

0.49

UBE2D1

7321

P51668

0.56

USP25

29761

Q9UHP3

0.72

MAD2L1

4085

Q13257

0.76

USP11

8237

P51784

0.76

ZMYM4

9202

Q5VZL5

0.76

ZMYM6

9204

O95789

0.76

COPS2

9318

P61201

0.76

NUDCD3

23386

Q8IVD9

0.76

COPS4

51138

Q9BT78

0.76

AURKB

9212

Q96GD4

0.80

KLHL22

84861

Q53GT1

0.86

KLHL9

55958

Q9P2J3

0.87

HSP90AA1

3320

P07900

0.63

NEDD8

4738

Q15843

0.63

NTRK1

4914

P04629

0.63

KLHL21

9903

Q9UJP4

0.63

DCUN1D1

54165

Q96GG9

0.63

CSPP1

79848

Q1MSJ5

0.63

KIFC3

3801

Q9BVG8

0.72

PRPS1

5631

P60891

0.72

TFG

10342

Q92734

0.72

TRIM29

23650

Q14134

0.72

UBXN7

26043

O94888

0.72

COPS7A

50813

Q9UBW8

0.72

CUL3

8452

Q13618

0.74

COPS6

10980

Q7L5N1

0.86

COPS5

10987

Q92905

0.86