| Gene Symbol | RBM17 |
| Entrez ID | 84991 |
| Uniprot ID | Q96I25 |
| Description | RNA binding motif protein 17 |
| Chromosomal Location | chr10: 6,088,987-6,117,457 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0000380 |
alternative mRNA splicing, via spliceosome |
The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. |
IMP |
|
CC |
GO:0005681 |
spliceosomal complex |
Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. |
IEA |
|
MF |
GO:0000166 |
nucleotide binding |
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
IEA |
|
MF |
GO:0003723 |
RNA binding |
Interacting selectively and non-covalently with an RNA molecule or a portion thereof. |
IEA |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
| Domain ID | Description |
|---|---|
|
IPR000467 |
G-patch domain |
|
IPR000504 |
RNA recognition motif domain |
|
IPR003954 |
RNA recognition motif domain, eukaryote |
|
IPR016967 |
Splicing factor, SPF45 |
|
IPR034653 |
SPF45, RNA recognition motif |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa03040 |
Spliceosome |
KEGG |
|
WP411 |
mRNA Processing |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0087012 |
Ataxia, Spinocerebellar |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
appendix |
lymphoid tissue |
|
bone marrow |
hematopoietic cells |
|
breast |
adipocytes |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
glial cells |
|
caudate |
neuronal cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
cells in molecular layer |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
endothelial cells |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
endothelial cells |
|
colon |
glandular cells |
|
colon |
peripheral nerve/ganglion |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
endometrium |
cells in endometrial stroma |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
hippocampus |
glial cells |
|
hippocampus |
neuronal cells |
|
kidney |
cells in tubules |
|
lung |
macrophages |
|
lung |
pneumocytes |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
pancreas |
exocrine glandular cells |
|
parathyroid gland |
glandular cells |
|
placenta |
decidual cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skeletal muscle |
myocytes |
|
skin |
fibroblasts |
|
skin |
keratinocytes |
|
skin |
Langerhans |
|
skin |
melanocytes |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
smooth muscle |
smooth muscle cells |
|
soft tissue |
adipocytes |
|
soft tissue |
chondrocytes |
|
soft tissue |
fibroblasts |
|
soft tissue |
peripheral nerve |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
|
26459919 |
Lan et al. |
2015 |
Functional microarray analysis of differentially expressed genes in granulosa cells from women with polycystic ovary syndrome related to MAPK/ERK signaling |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
SON |
6651 |
P18583 |
0.49 |
|
SCHIP1 |
29970 |
Q9P0W5 |
0.49 |
|
U2AF2 |
11338 |
P26368 |
0.56 |
|
U2SURP |
23350 |
O15042 |
0.63 |
|
SAP30BP |
29115 |
Q9UHR5 |
0.63 |
|
CWC15 |
51503 |
Q9P013 |
0.63 |
|
FAM9B |
171483 |
Q8IZU0 |
0.63 |
|
CSNK2A1 |
1457 |
P68400 |
0.70 |
|
GOLGA2 |
2801 |
Q08379 |
0.73 |
|
SUGP1 |
57794 |
Q8IWZ8 |
0.76 |
|
BARD1 |
580 |
Q99728 |
0.63 |
|
CDC5L |
988 |
Q99459 |
0.63 |
|
CDK2 |
1017 |
P24941 |
0.63 |
|
ELAVL1 |
1994 |
Q15717 |
0.63 |
|
JUN |
3725 |
P05412 |
0.63 |
|
SUMO2 |
6613 |
P61956 |
0.63 |
|
XPO1 |
7514 |
O14980 |
0.63 |
|
ZRSR2 |
8233 |
Q15696 |
0.63 |
|
HIST1H3A |
8350 |
P68431 |
0.63 |
|
CUL3 |
8452 |
Q13618 |
0.63 |
|
MDC1 |
9656 |
Q14676 |
0.63 |
|
KIAA0101 |
9768 |
Q15004 |
0.63 |
|
SNW1 |
22938 |
Q13573 |
0.63 |
|
OBSL1 |
23363 |
O75147 |
0.63 |
|
HINFP |
25988 |
Q9BQA5 |
0.63 |
|
DDX41 |
51428 |
Q9UJV9 |
0.63 |
|
CCHCR1 |
54535 |
Q8TD31 |
0.63 |
|
PPP1R12C |
54776 |
Q9BZL4 |
0.63 |
|
QRICH1 |
54870 |
Q2TAL8 |
0.63 |
|
CEP55 |
55165 |
Q53EZ4 |
0.63 |
|
SMURF1 |
57154 |
Q9HCE7 |
0.63 |
|
KIAA1683 |
80726 |
Q9H0B3 |
0.63 |
|
WDFY2 |
115825 |
Q96P53 |
0.63 |
|
LNX2 |
222484 |
Q8N448 |
0.63 |
|
APBB1 |
322 |
O00213 |
0.68 |
|
MYO1C |
4641 |
O00159 |
0.72 |
|
PPP3CB |
5532 |
P16298 |
0.72 |
|
XRCC3 |
7517 |
O43542 |
0.72 |
|
EMC2 |
9694 |
Q15006 |
0.72 |
|
MMGT1 |
93380 |
Q8N4V1 |
0.72 |
|
SAT1 |
6303 |
P21673 |
0.74 |
|
SF3A2 |
8175 |
Q15428 |
0.82 |
|
DHX15 |
1665 |
O43143 |
0.86 |
|
SF1 |
7536 |
Q15637 |
0.88 |
|
SF3B1 |
23451 |
O75533 |
0.89 |