| Gene Symbol | ST6GAL2 |
| Entrez ID | 84620 |
| Uniprot ID | Q96JF0 |
| Description | ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 |
| Chromosomal Location | chr2: 106,801,600-106,887,108 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0007275 | multicellular organism development |
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). | NAS |
BP | GO:0009311 | oligosaccharide metabolic process |
The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. | IDA |
BP | GO:0018279 | protein N-linked glycosylation via asparagine |
The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification. | IBA |
BP | GO:0040007 | growth |
The increase in size or mass of an entire organism, a part of an organism or a cell. | NAS |
BP | GO:0097503 | sialylation |
The covalent attachment of sialic acid to a substrate molecule. | IEA |
CC | GO:0000139 | Golgi membrane |
The lipid bilayer surrounding any of the compartments of the Golgi apparatus. | TAS |
CC | GO:0016021 | integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. | NAS |
CC | GO:0032580 | Golgi cisterna membrane |
The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. | IEA |
MF | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity |
Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine. | IDA|TAS |
| Domain ID | Description |
|---|---|
IPR001675 | Glycosyl transferase family 29 |
IPR011330 | Glycoside hydrolase/deacetylase, beta/alpha-barrel |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
hsa00510 | N-Glycan biosynthesis | KEGG |
hsa00514 | Other types of O-glycan biosynthesis | KEGG |
hsa01100 | Metabolic pathways | KEGG |
WP1424 | Globo Sphingolipid Metabolism | WikiPathways |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
22617121 | Ouandaogo et al. | 2012 | Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
ST6GAL2 | 84620 | Q96JF0 | 0.52 |
MCM7 | 4176 | P33993 | 0.63 |
CREB3 | 10488 | O43889 | 0.63 |