Protein Description

Gene Symbol ST6GAL2
Entrez ID 84620
Uniprot ID Q96JF0
Description ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
Chromosomal Location chr2: 106,801,600-106,887,108
Ontology GO ID GO Term Definition Evidence

BP

GO:0007275

multicellular organism development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

NAS

BP

GO:0009311

oligosaccharide metabolic process

The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.

IDA

BP

GO:0018279

protein N-linked glycosylation via asparagine

The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification.

IBA

BP

GO:0040007

growth

The increase in size or mass of an entire organism, a part of an organism or a cell.

NAS

BP

GO:0097503

sialylation

The covalent attachment of sialic acid to a substrate molecule.

IEA

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

TAS

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

NAS

CC

GO:0032580

Golgi cisterna membrane

The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex.

IEA

MF

GO:0003835

beta-galactoside alpha-2,6-sialyltransferase activity

Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine.

IDA|TAS

Domain ID Description

IPR001675

Glycosyl transferase family 29

IPR011330

Glycoside hydrolase/deacetylase, beta/alpha-barrel

Pathway ID Pathway Term Pathway Source

hsa00510

N-Glycan biosynthesis

KEGG

hsa00514

Other types of O-glycan biosynthesis

KEGG

hsa01100

Metabolic pathways

KEGG

WP1424

Globo Sphingolipid Metabolism

WikiPathways

No diseases found.

No tissues found.

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

ST6GAL2

84620

Q96JF0

0.52

MCM7

4176

P33993

0.63

CREB3

10488

O43889

0.63