Protein Description

Gene Symbol ACSS1
Entrez ID 84532
Uniprot ID Q9NUB1
Description acyl-CoA synthetase short-chain family member 1
Chromosomal Location chr20: 25,006,230-25,058,980
Ontology GO ID GO Term Definition Evidence

BP

GO:0006069

ethanol oxidation

An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate.

TAS

BP

GO:0006085

acetyl-CoA biosynthetic process

The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.

IDA

BP

GO:0019413

acetate biosynthetic process

The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid.

IEA

BP

GO:0019427

acetyl-CoA biosynthetic process from acetate

The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate.

IEA

BP

GO:0019542

propionate biosynthetic process

The chemical reactions and pathways resulting in the formation of propionate, the anion derived from propionic acid.

IEA

CC

GO:0005759

mitochondrial matrix

The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

IDA|TAS

MF

GO:0003987

acetate-CoA ligase activity

Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.

EXP|IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

MF

GO:0016208

AMP binding

Interacting selectively and non-covalently with AMP, adenosine monophosphate.

IEA

Domain ID Description

IPR000873

AMP-dependent synthetase/ligase

IPR011904

Acetate-CoA ligase

IPR020845

AMP-binding, conserved site

IPR025110

AMP-binding enzyme C-terminal domain

IPR032387

Acetyl-coenzyme A synthetase, N-terminal domain

Pathway ID Pathway Term Pathway Source

hsa00010

Glycolysis / Gluconeogenesis

KEGG

hsa00620

Pyruvate metabolism

KEGG

hsa00640

Propanoate metabolism

KEGG

hsa01100

Metabolic pathways

KEGG

hsa01200

Carbon metabolism

KEGG

WP1982

Sterol Regulatory Element-Binding Proteins (SREBP) signalling

WikiPathways

WP430

Statin Pathway

WikiPathways

WP3925

Amino Acid metabolism

WikiPathways

No diseases found.

Tissue Cell Type

bronchus

respiratory epithelial cells

esophagus

squamous epithelial cells

heart muscle

myocytes

kidney

cells in tubules

placenta

trophoblastic cells

small intestine

glandular cells

stomach

glandular cells

testis

Leydig cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

CLPP

8192

Q16740

0.49

PPA2

27068

Q9H2U2

0.63

VAC14

55697

Q08AM6

0.63