Gene Symbol | ACSS1 |
Entrez ID | 84532 |
Uniprot ID | Q9NUB1 |
Description | acyl-CoA synthetase short-chain family member 1 |
Chromosomal Location | chr20: 25,006,230-25,058,980 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006069 |
ethanol oxidation |
An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate. |
TAS |
BP |
GO:0006085 |
acetyl-CoA biosynthetic process |
The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated. |
IDA |
BP |
GO:0019413 |
acetate biosynthetic process |
The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid. |
IEA |
BP |
GO:0019427 |
acetyl-CoA biosynthetic process from acetate |
The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate. |
IEA |
BP |
GO:0019542 |
propionate biosynthetic process |
The chemical reactions and pathways resulting in the formation of propionate, the anion derived from propionic acid. |
IEA |
CC |
GO:0005759 |
mitochondrial matrix |
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
IDA|TAS |
MF |
GO:0003987 |
acetate-CoA ligase activity |
Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. |
EXP|IDA |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IEA |
MF |
GO:0016208 |
AMP binding |
Interacting selectively and non-covalently with AMP, adenosine monophosphate. |
IEA |
Domain ID | Description |
---|---|
IPR000873 |
AMP-dependent synthetase/ligase |
IPR011904 |
Acetate-CoA ligase |
IPR020845 |
AMP-binding, conserved site |
IPR025110 |
AMP-binding enzyme C-terminal domain |
IPR032387 |
Acetyl-coenzyme A synthetase, N-terminal domain |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00010 |
Glycolysis / Gluconeogenesis |
KEGG |
hsa00620 |
Pyruvate metabolism |
KEGG |
hsa00640 |
Propanoate metabolism |
KEGG |
hsa01100 |
Metabolic pathways |
KEGG |
hsa01200 |
Carbon metabolism |
KEGG |
WP1982 |
Sterol Regulatory Element-Binding Proteins (SREBP) signalling |
WikiPathways |
WP430 |
Statin Pathway |
WikiPathways |
WP3925 |
Amino Acid metabolism |
WikiPathways |
Tissue | Cell Type |
---|---|
bronchus |
respiratory epithelial cells |
esophagus |
squamous epithelial cells |
heart muscle |
myocytes |
kidney |
cells in tubules |
placenta |
trophoblastic cells |
small intestine |
glandular cells |
stomach |
glandular cells |
testis |
Leydig cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
CLPP |
8192 |
Q16740 |
0.49 |
PPA2 |
27068 |
Q9H2U2 |
0.63 |
VAC14 |
55697 |
Q08AM6 |
0.63 |