| Gene Symbol | USP48 |
| Entrez ID | 84196 |
| Uniprot ID | Q86UV5 |
| Description | ubiquitin specific peptidase 48 |
| Chromosomal Location | chr1: 21,678,298-21,783,606 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0006511 | ubiquitin-dependent protein catabolic process |
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. | IEA |
BP | GO:0016579 | protein deubiquitination |
The removal of one or more ubiquitin groups from a protein. | IEA |
CC | GO:0005654 | nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. | IDA |
CC | GO:0005737 | cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | IDA |
CC | GO:0005739 | mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. | IDA |
MF | GO:0004843 | thiol-dependent ubiquitin-specific protease activity |
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein. | IEA |
| Domain ID | Description |
|---|---|
IPR000626 | Ubiquitin domain |
IPR001394 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase |
IPR006615 | Peptidase C19, ubiquitin-specific peptidase, DUSP domain |
IPR018200 | Ubiquitin specific protease, conserved site |
IPR028889 | Ubiquitin specific protease domain |
IPR029071 | Ubiquitin-related domain |
IPR033841 | Ubiquitin-specific peptidase 48 |
| UMLS CUI | UMLS Term |
|---|---|
C0236733 | Amphetamine-Related Disorders |
| Tissue | Cell Type |
|---|---|
appendix | glandular cells |
bronchus | respiratory epithelial cells |
caudate | neuronal cells |
cerebellum | Purkinje cells |
cerebral cortex | neuronal cells |
colon | glandular cells |
epididymis | glandular cells |
esophagus | squamous epithelial cells |
gallbladder | glandular cells |
hippocampus | neuronal cells |
nasopharynx | respiratory epithelial cells |
placenta | decidual cells |
placenta | trophoblastic cells |
prostate | glandular cells |
rectum | glandular cells |
salivary gland | glandular cells |
small intestine | glandular cells |
stomach | glandular cells |
tonsil | squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
22951915 | Haozi et al. | 2012 | Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
UCHL3 | 7347 | P15374 | 0.49 |
NCBP2 | 22916 | P52298 | 0.49 |
NUP188 | 23511 | Q5SRE5 | 0.49 |
DYNC1LI1 | 51143 | Q9Y6G9 | 0.49 |
ZFR | 51663 | Q96KR1 | 0.49 |
ZC3HAV1 | 56829 | Q7Z2W4 | 0.49 |
APP | 351 | P05067 | 0.56 |
PSAP | 5660 | P07602 | 0.63 |
SLC9A3 | 6550 | P48764 | 0.63 |
SEC24D | 9871 | O94855 | 0.63 |
EEF1B2P5 | 442227 | 0.72 |
|
VPS35 | 55737 | Q96QK1 | 0.73 |
HIST1H2BC; HIST1H2BE; HIST1H2BF; HIST1H2BG; HIST1H2BI | 8339 | P62807 | 0.49 |
HIST1H3A | 8350 | P68431 | 0.49 |
UACA | 55075 | Q9BZF9 | 0.49 |
CSNK2A1 | 1457 | P68400 | 0.52 |
UBA6 | 55236 | A0AVT1 | 0.59 |
GPS1 | 2873 | Q13098 | 0.63 |
MYC | 4609 | P01106 | 0.63 |
NTRK1 | 4914 | P04629 | 0.63 |
SNW1 | 22938 | Q13573 | 0.63 |
SIRT6 | 51548 | Q8N6T7 | 0.63 |
BRAT1 | 221927 | Q6PJG6 | 0.63 |
DRD3 | 1814 | P35462 | 0.72 |
USP21 | 27005 | Q9UK80 | 0.76 |