| Gene Symbol | USP48 |
| Entrez ID | 84196 |
| Uniprot ID | Q86UV5 |
| Description | ubiquitin specific peptidase 48 |
| Chromosomal Location | chr1: 21,678,298-21,783,606 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. |
IEA |
|
BP |
GO:0016579 |
protein deubiquitination |
The removal of one or more ubiquitin groups from a protein. |
IEA |
|
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
IDA |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
|
CC |
GO:0005739 |
mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
IDA |
|
MF |
GO:0004843 |
thiol-dependent ubiquitin-specific protease activity |
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein. |
IEA |
| Domain ID | Description |
|---|---|
|
IPR000626 |
Ubiquitin domain |
|
IPR001394 |
Peptidase C19, ubiquitin carboxyl-terminal hydrolase |
|
IPR006615 |
Peptidase C19, ubiquitin-specific peptidase, DUSP domain |
|
IPR018200 |
Ubiquitin specific protease, conserved site |
|
IPR028889 |
Ubiquitin specific protease domain |
|
IPR029071 |
Ubiquitin-related domain |
|
IPR033841 |
Ubiquitin-specific peptidase 48 |
| UMLS CUI | UMLS Term |
|---|---|
|
C0236733 |
Amphetamine-Related Disorders |
| Tissue | Cell Type |
|---|---|
|
appendix |
glandular cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
neuronal cells |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
neuronal cells |
|
colon |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
gallbladder |
glandular cells |
|
hippocampus |
neuronal cells |
|
nasopharynx |
respiratory epithelial cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
small intestine |
glandular cells |
|
stomach |
glandular cells |
|
tonsil |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
UCHL3 |
7347 |
P15374 |
0.49 |
|
NCBP2 |
22916 |
P52298 |
0.49 |
|
NUP188 |
23511 |
Q5SRE5 |
0.49 |
|
DYNC1LI1 |
51143 |
Q9Y6G9 |
0.49 |
|
ZFR |
51663 |
Q96KR1 |
0.49 |
|
ZC3HAV1 |
56829 |
Q7Z2W4 |
0.49 |
|
APP |
351 |
P05067 |
0.56 |
|
PSAP |
5660 |
P07602 |
0.63 |
|
SLC9A3 |
6550 |
P48764 |
0.63 |
|
SEC24D |
9871 |
O94855 |
0.63 |
|
EEF1B2P5 |
442227 |
N/A |
0.72 |
|
VPS35 |
55737 |
Q96QK1 |
0.73 |
|
HIST1H2BC; HIST1H2BE; HIST1H2BF; HIST1H2BG; HIST1H2BI |
8339 |
P62807 |
0.49 |
|
HIST1H3A |
8350 |
P68431 |
0.49 |
|
UACA |
55075 |
Q9BZF9 |
0.49 |
|
CSNK2A1 |
1457 |
P68400 |
0.52 |
|
UBA6 |
55236 |
A0AVT1 |
0.59 |
|
GPS1 |
2873 |
Q13098 |
0.63 |
|
MYC |
4609 |
P01106 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
SNW1 |
22938 |
Q13573 |
0.63 |
|
SIRT6 |
51548 |
Q8N6T7 |
0.63 |
|
BRAT1 |
221927 |
Q6PJG6 |
0.63 |
|
DRD3 |
1814 |
P35462 |
0.72 |
|
USP21 |
27005 |
Q9UK80 |
0.76 |