Protein Description

Gene Symbol LONP2
Entrez ID 83752
Uniprot ID Q86WA8
Description lon peptidase 2, peroxisomal
Chromosomal Location chr16: 48,244,296-48,363,122
Ontology GO ID GO Term Definition Evidence

BP

GO:0006515

misfolded or incompletely synthesized protein catabolic process

The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins.

IBA

BP

GO:0006625

protein targeting to peroxisome

The process of directing proteins towards the peroxisome, usually using signals contained within the protein.

IMP

BP

GO:0007031

peroxisome organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.

NAS

BP

GO:0014070

response to organic cyclic compound

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.

IEA

BP

GO:0016485

protein processing

Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.

IMP

BP

GO:0016558

protein import into peroxisome matrix

The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix.

IEA

BP

GO:0031998

regulation of fatty acid beta-oxidation

Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation.

IMP

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IEA

CC

GO:0005777

peroxisome

A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

IDA

CC

GO:0005782

peroxisomal matrix

The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase.

IBA

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IDA

MF

GO:0002020

protease binding

Interacting selectively and non-covalently with any protease or peptidase.

IPI

MF

GO:0004176

ATP-dependent peptidase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds.

IBA

MF

GO:0004252

serine-type endopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

IEA

MF

GO:0005102

receptor binding

Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

IPI

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

MF

GO:0008233

peptidase activity

Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.

IDA

MF

GO:0019899

enzyme binding

Interacting selectively and non-covalently with any enzyme.

IPI

Domain ID Description

IPR003111

Lon, substrate-binding domain

IPR003593

AAA+ ATPase domain

IPR003959

ATPase, AAA-type, core

IPR004815

Lon protease, bacterial/eukaryotic-type

IPR008268

Peptidase S16, active site

IPR008269

Peptidase S16, Lon proteolytic domain

IPR014721

Ribosomal protein S5 domain 2-type fold, subgroup

IPR015947

PUA-like domain

IPR020568

Ribosomal protein S5 domain 2-type fold

IPR027065

Lon protease

IPR027417

P-loop containing nucleoside triphosphate hydrolase

IPR027501

Lon protease homologue 2, peroxisomal

No pathways found.

No diseases found.

Tissue Cell Type

caudate

glial cells

cervix, uterine

glandular cells

endometrium

glandular cells

esophagus

squamous epithelial cells

fallopian tube

glandular cells

kidney

cells in glomeruli

kidney

cells in tubules

salivary gland

glandular cells

testis

cells in seminiferous ducts

thyroid gland

glandular cells

tonsil

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

PEX14

5195

O75381

0.52

DCN

1634

P07585

0.63

ELAVL1

1994

Q15717

0.63

IL17A

3605

Q16552

0.63

RB1CC1

9821

Q8TDY2

0.63

OS9

10956

Q13438

0.63

FBXW11

23291

Q9UKB1

0.63

WWOX

51741

Q9NZC7

0.63

TYSND1

219743

Q2T9J0

0.63

RSPH9

221421

Q9H1X1

0.63

PEX5

5830

P50542

0.73

AMOT

154796

Q4VCS5

0.76