Protein Description

Gene Symbol TRPT1
Entrez ID 83707
Uniprot ID Q86TN4
Description tRNA phosphotransferase 1
Chromosomal Location chr11: 64,223,799-64,226,254
Ontology GO ID GO Term Definition Evidence

BP

GO:0006388

tRNA splicing, via endonucleolytic cleavage and ligation

Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.

IEA

BP

GO:0045859

regulation of protein kinase activity

Any process that modulates the frequency, rate or extent of protein kinase activity.

IEA

MF

GO:0000215

tRNA 2'-phosphotransferase activity

Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate.

IEA

Domain ID Description

IPR002745

Phosphotransferase KptA/Tpt1

No pathways found.

No diseases found.

Tissue Cell Type

adrenal gland

glandular cells

bronchus

respiratory epithelial cells

cerebellum

Purkinje cells

duodenum

glandular cells

esophagus

squamous epithelial cells

gallbladder

glandular cells

kidney

cells in tubules

liver

hepatocytes

lymph node

germinal center cells

lymph node

non-germinal center cells

testis

cells in seminiferous ducts

testis

Leydig cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

APP

351

P05067

0.56

EEFSEC

60678

P57772

0.49

TRAF2

7186

Q12933

0.73