Gene Symbol | TRPT1 |
Entrez ID | 83707 |
Uniprot ID | Q86TN4 |
Description | tRNA phosphotransferase 1 |
Chromosomal Location | chr11: 64,223,799-64,226,254 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006388 |
tRNA splicing, via endonucleolytic cleavage and ligation |
Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. |
IEA |
BP |
GO:0045859 |
regulation of protein kinase activity |
Any process that modulates the frequency, rate or extent of protein kinase activity. |
IEA |
MF |
GO:0000215 |
tRNA 2'-phosphotransferase activity |
Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate. |
IEA |
Domain ID | Description |
---|---|
IPR002745 |
Phosphotransferase KptA/Tpt1 |
Tissue | Cell Type |
---|---|
adrenal gland |
glandular cells |
bronchus |
respiratory epithelial cells |
cerebellum |
Purkinje cells |
duodenum |
glandular cells |
esophagus |
squamous epithelial cells |
gallbladder |
glandular cells |
kidney |
cells in tubules |
liver |
hepatocytes |
lymph node |
germinal center cells |
lymph node |
non-germinal center cells |
testis |
cells in seminiferous ducts |
testis |
Leydig cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
APP |
351 |
P05067 |
0.56 |
EEFSEC |
60678 |
P57772 |
0.49 |
TRAF2 |
7186 |
Q12933 |
0.73 |