| Gene Symbol | CDT1 |
| Entrez ID | 81620 |
| Uniprot ID | Q9H211 |
| Description | chromatin licensing and DNA replication factor 1 |
| Chromosomal Location | chr16: 88,803,213-88,809,258 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0000076 |
DNA replication checkpoint |
A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. |
IDA |
|
BP |
GO:0000082 |
G1/S transition of mitotic cell cycle |
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. |
TAS |
|
BP |
GO:0000083 |
regulation of transcription involved in G1/S transition of mitotic cell cycle |
Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle. |
TAS |
|
BP |
GO:0006260 |
DNA replication |
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
IEA |
|
BP |
GO:0030174 |
regulation of DNA-dependent DNA replication initiation |
Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase. |
IDA |
|
BP |
GO:0033262 |
regulation of nuclear cell cycle DNA replication |
Any process that modulates the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle. |
IEA |
|
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
|
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
TAS |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
|
MF |
GO:0003677 |
DNA binding |
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
ISS |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
| Domain ID | Description |
|---|---|
|
IPR011991 |
Winged helix-turn-helix DNA-binding domain |
|
IPR014939 |
CDT1 Geminin-binding domain-like |
|
IPR032054 |
DNA replication factor Cdt1, C-terminal |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
WP466 |
DNA Replication |
WikiPathways |
|
WP2446 |
Retinoblastoma (RB) in Cancer |
WikiPathways |
|
h_mcmPathway |
CDK Regulation of DNA Replication |
BioCarta |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
breast |
glandular cells |
|
bronchus |
respiratory epithelial cells |
|
cerebellum |
cells in molecular layer |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
endothelial cells |
|
colon |
glandular cells |
|
colon |
peripheral nerve/ganglion |
|
endometrium |
cells in endometrial stroma |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
hippocampus |
glial cells |
|
hippocampus |
neuronal cells |
|
kidney |
cells in glomeruli |
|
kidney |
cells in tubules |
|
lung |
pneumocytes |
|
nasopharynx |
respiratory epithelial cells |
|
ovary |
follicle cells |
|
ovary |
ovarian stroma cells |
|
pancreas |
exocrine glandular cells |
|
parathyroid gland |
glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skeletal muscle |
myocytes |
|
skin |
fibroblasts |
|
skin |
keratinocytes |
|
skin |
Langerhans |
|
skin |
melanocytes |
|
skin |
epidermal cells |
|
soft tissue |
fibroblasts |
|
soft tissue |
adipocytes |
|
soft tissue |
peripheral nerve |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
thyroid gland |
glandular cells |
|
urinary bladder |
urothelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
DGCR8 |
54487 |
Q8WYQ5 |
0.49 |
|
CDT1 |
81620 |
Q9H211 |
0.52 |
|
FOXO3 |
2309 |
O43524 |
0.56 |
|
CCNE1 |
898 |
P24864 |
0.63 |
|
CDK4 |
1019 |
P11802 |
0.63 |
|
DDB2 |
1643 |
Q92466 |
0.63 |
|
MCM2 |
4171 |
P49736 |
0.63 |
|
MAPK8 |
5599 |
P45983 |
0.63 |
|
MAPK9 |
5601 |
P45984 |
0.63 |
|
MAPK14 |
1432 |
Q16539 |
0.65 |
|
MAPK1 |
5594 |
P28482 |
0.65 |
|
CCNB1 |
891 |
P14635 |
0.68 |
|
CDC5L |
988 |
Q99459 |
0.70 |
|
ORC1 |
4998 |
Q13415 |
0.70 |
|
FBXO31 |
79791 |
Q5XUX0 |
0.70 |
|
TIMM8A |
1678 |
O60220 |
0.72 |
|
E2F1 |
1869 |
Q01094 |
0.72 |
|
KPNB1 |
3837 |
Q14974 |
0.72 |
|
KPNA2 |
3838 |
P52292 |
0.72 |
|
TFDP1 |
7027 |
Q14186 |
0.72 |
|
CUL1 |
8454 |
Q13616 |
0.72 |
|
TRIP4 |
9325 |
Q15650 |
0.72 |
|
BZW1 |
9689 |
Q7L1Q6 |
0.72 |
|
TIMM13 |
26517 |
Q9Y5L4 |
0.72 |
|
ANAPC5 |
51433 |
Q9UJX4 |
0.72 |
|
TRAPPC13 |
80006 |
A5PLN9 |
0.72 |
|
ANKHD1 |
404734 |
Q8IWZ3 |
0.72 |
|
CDC20 |
991 |
Q12834 |
0.75 |
|
MCM7 |
4176 |
P33993 |
0.75 |
|
ORC2 |
4999 |
Q13416 |
0.76 |
|
MCM4 |
4173 |
P33991 |
0.78 |
|
NPM1 |
4869 |
P06748 |
0.78 |
|
CDC23 |
8697 |
Q9UJX2 |
0.78 |
|
BAZ1B |
9031 |
Q9UIG0 |
0.78 |
|
FZR1 |
51343 |
Q9UM11 |
0.78 |
|
ANAPC7 |
51434 |
Q9UJX3 |
0.78 |
|
HDAC11 |
79885 |
Q96DB2 |
0.78 |
|
TOP1 |
7150 |
P11387 |
0.79 |
|
TOP2A |
7153 |
P11388 |
0.79 |
|
GRWD1 |
83743 |
Q9BQ67 |
0.79 |
|
CCNA1 |
8900 |
P78396 |
0.83 |
|
CDK1 |
983 |
P06493 |
0.84 |
|
DDB1 |
100290337 |
Q16531 |
0.84 |
|
CCNA2 |
890 |
P20248 |
0.89 |
|
CDC6 |
990 |
Q99741 |
0.89 |
|
SMARCA5 |
8467 |
O60264 |
0.89 |
|
CDK2 |
1017 |
P24941 |
0.90 |
|
PCNA |
5111 |
P12004 |
0.90 |
|
SKP2 |
6502 |
Q13309 |
0.90 |
|
MCM6 |
4175 |
Q14566 |
0.97 |
|
GMNN |
51053 |
O75496 |
0.97 |
|
COPS5 |
10987 |
Q92905 |
0.49 |
|
EP300 |
2033 |
Q09472 |
0.52 |
|
KAT2B |
8850 |
Q92831 |
0.52 |
|
CDK3 |
1018 |
Q00526 |
0.63 |
|
TP73 |
7161 |
O15350 |
0.63 |
|
XPO1 |
7514 |
O14980 |
0.63 |
|
TP63 |
8626 |
Q9H3D4 |
0.63 |
|
FAF1 |
11124 |
Q9UNN5 |
0.63 |
|
HECW2 |
57520 |
Q9P2P5 |
0.63 |
|
HAUS1 |
115106 |
Q96CS2 |
0.63 |
|
CUL4B |
8450 |
Q13620 |
0.65 |
|
DTL |
51514 |
Q9NZJ0 |
0.70 |
|
SLAIN2 |
57606 |
Q9P270 |
0.72 |
|
CUL4A |
8451 |
Q13619 |
0.76 |
|
KAT7 |
11143 |
O95251 |
0.78 |