BP

GO:0000495

box H/ACA snoRNA 3'-end processing

Any process involved in forming the mature 3' end of a box H/ACA snoRNA molecule.

IBA

BP

GO:0006364

rRNA processing

Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

TAS

BP

GO:0006396

RNA processing

Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.

TAS

BP

GO:0007004

telomere maintenance via telomerase

The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase.

IDA|TAS

BP

GO:0008283

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

TAS

BP

GO:0031118

rRNA pseudouridine synthesis

The intramolecular conversion of uridine to pseudouridine in an rRNA molecule.

IBA|TAS

BP

GO:0031120

snRNA pseudouridine synthesis

The intramolecular conversion of uridine to pseudouridine in an snRNA molecule.

IBA

BP

GO:0032212

positive regulation of telomere maintenance via telomerase

Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.

IEA

BP

GO:0051973

positive regulation of telomerase activity

Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

IMP

BP

GO:0090669

telomerase RNA stabilization

Prevention of degradation of telomerase RNA (TERC) molecules.

IMP

BP

GO:1904851

positive regulation of establishment of protein localization to telomere

Any process that activates or increases the frequency, rate or extent of establishment of protein localization to telomere.

IMP

BP

GO:1904874

positive regulation of telomerase RNA localization to Cajal body

Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body.

IMP

BP

GO:1990481

mRNA pseudouridine synthesis

The intramolecular conversion of uridine to pseudouridine in an mRNA molecule.

IBA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

IDA|TAS

CC

GO:0005697

telomerase holoenzyme complex

Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits.

IDA|TAS

CC

GO:0005730

nucleolus

A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IEA

CC

GO:0031429

box H/ACA snoRNP complex

A box H/ACA RNP complex that is located in the nucleolus.

IDA|TAS

CC

GO:0072589

box H/ACA scaRNP complex

A box H/ACA RNP complex that is located in the Cajal body of the nucleoplasm. In higher eukaryotes, box H/ACA RNP located in Cajal bodies mediate pseudouridylation of spliceosomal snRNAs.

TAS

CC

GO:0090661

box H/ACA telomerase RNP complex

A box H/ACA ribonucleoprotein complex that contains the RNA component of vertebrate telomerase, the enzyme essential for the replication of chromosome termini in most eukaryotes. This ribonucleoprotein complex is a structural box H/ACA RNP, which does not have the catalytic pseudouridylation function shared by the majority of H/ACA RNPs present in the cell.

IDA|TAS

MF

GO:0003720

telomerase activity

Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence.

IDA

MF

GO:0003723

RNA binding

Interacting selectively and non-covalently with an RNA molecule or a portion thereof.

TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0009982

pseudouridine synthase activity

Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.

IBA

MF

GO:0034513

box H/ACA snoRNA binding

Interacting selectively and non-covalently with box H/ACA small nucleolar RNA.

IPI

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA

MF

GO:0070034

telomerase RNA binding

Interacting selectively and non-covalently with the telomerase RNA template.

IPI