BP

GO:0002761

regulation of myeloid leukocyte differentiation

Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation.

IEA

BP

GO:0002829

negative regulation of type 2 immune response

Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response.

IEA

BP

GO:0006879

cellular iron ion homeostasis

Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.

IMP

BP

GO:0007034

vacuolar transport

The directed movement of substances into, out of or within a vacuole.

IEA

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

IEA

BP

GO:0010629

negative regulation of gene expression

Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

IMP

BP

GO:0030001

metal ion transport

The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

IEA

BP

GO:0031398

positive regulation of protein ubiquitination

Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.

IDA|IMP

BP

GO:0032410

negative regulation of transporter activity

Any process that stops or reduces the activity of a transporter.

IMP

BP

GO:0032713

negative regulation of interleukin-4 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production.

IEA

BP

GO:0042130

negative regulation of T cell proliferation

Any process that stops, prevents or reduces the rate or extent of T cell proliferation.

IEA

BP

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.

IMP

BP

GO:0043162

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation.

IEA

BP

GO:0045619

regulation of lymphocyte differentiation

Any process that modulates the frequency, rate or extent of lymphocyte differentiation.

IEA

BP

GO:0045732

positive regulation of protein catabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.

IEA

BP

GO:0048294

negative regulation of isotype switching to IgE isotypes

Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgE isotypes.

IEA

BP

GO:0048302

regulation of isotype switching to IgG isotypes

Any process that modulates the frequency, rate or extent of isotype switching to IgG isotypes.

IEA

BP

GO:0050728

negative regulation of inflammatory response

Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.

IEA

BP

GO:0051224

negative regulation of protein transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

IMP

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

IEA

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

IEA

CC

GO:0005938

cell cortex

The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.

IEA

CC

GO:0010008

endosome membrane

The lipid bilayer surrounding an endosome.

IEA

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

CC

GO:0048471

perinuclear region of cytoplasm

Cytoplasm situated near, or occurring around, the nucleus.

IDA

MF

GO:0004871

signal transducer activity

Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.

IMP

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI