BP

GO:0000209

protein polyubiquitination

Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.

IDA

BP

GO:0006471

protein ADP-ribosylation

The transfer, from NAD, of ADP-ribose to protein amino acids.

IDA

BP

GO:0016055

Wnt signaling pathway

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

TAS

BP

GO:0032212

positive regulation of telomere maintenance via telomerase

Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.

IC

BP

GO:0035264

multicellular organism growth

The increase in size or mass of an entire multicellular organism, as opposed to cell growth.

IEA

BP

GO:0040014

regulation of multicellular organism growth

Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.

IEA

BP

GO:0070198

protein localization to chromosome, telomeric region

Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome.

IMP

BP

GO:0070213

protein auto-ADP-ribosylation

The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein.

IDA

BP

GO:0090263

positive regulation of canonical Wnt signaling pathway

Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.

IMP|TAS

BP

GO:1904355

positive regulation of telomere capping

Any process that activates or increases the frequency, rate or extent of telomere capping.

IDA|IMP

BP

GO:1904357

negative regulation of telomere maintenance via telomere lengthening

Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance via telomere lengthening.

IMP

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

IEA

CC

GO:0000242

pericentriolar material

A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome.

IDA

CC

GO:0000784

nuclear chromosome, telomeric region

The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.

IC

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005635

nuclear envelope

The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0048471

perinuclear region of cytoplasm

Cytoplasm situated near, or occurring around, the nucleus.

IDA

MF

GO:0003950

NAD+ ADP-ribosyltransferase activity

Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

IDA|TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0019899

enzyme binding

Interacting selectively and non-covalently with any enzyme.

IPI

MF

GO:0046872

metal ion binding

Interacting selectively and non-covalently with any metal ion.

IEA