| Gene Symbol | ORAI2 |
| Entrez ID | 80228 |
| Uniprot ID | Q96SN7 |
| Description | ORAI calcium release-activated calcium modulator 2 |
| Chromosomal Location | chr7: 102,433,106-102,456,821 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0002115 | store-operated calcium entry |
A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum. | IBA |
BP | GO:0070588 | calcium ion transmembrane transport |
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. | IEA |
CC | GO:0016020 | membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. | IBA |
CC | GO:0016021 | integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. | IEA |
CC | GO:0030426 | growth cone |
The migrating motile tip of a growing nerve cell axon or dendrite. | IEA |
MF | GO:0005515 | protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). | IPI |
MF | GO:0015279 | store-operated calcium channel activity |
A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. | IBA |
| Domain ID | Description |
|---|---|
IPR012446 | Calcium release-activated calcium channel protein |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
hsa04020 | Calcium signaling pathway | KEGG |
| Tissue | Cell Type |
|---|---|
adrenal gland | glandular cells |
heart muscle | myocytes |
lung | macrophages |
ovary | follicle cells |
smooth muscle | smooth muscle cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
22617121 | Ouandaogo et al. | 2012 | Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
UNC119 | 9094 | Q13432 | 0.63 |
SETDB1 | 9869 | Q15047 | 0.63 |
MED31 | 51003 | Q9Y3C7 | 0.63 |
GDF9 | 2661 | O60383 | 0.63 |
COPS6 | 10980 | Q7L5N1 | 0.63 |
CRACR2A | 84766 | Q9BSW2 | 0.63 |