| Gene Symbol | ORAI2 |
| Entrez ID | 80228 |
| Uniprot ID | Q96SN7 |
| Description | ORAI calcium release-activated calcium modulator 2 |
| Chromosomal Location | chr7: 102,433,106-102,456,821 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0002115 |
store-operated calcium entry |
A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum. |
IBA |
|
BP |
GO:0070588 |
calcium ion transmembrane transport |
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
IEA |
|
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IBA |
|
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IEA |
|
CC |
GO:0030426 |
growth cone |
The migrating motile tip of a growing nerve cell axon or dendrite. |
IEA |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0015279 |
store-operated calcium channel activity |
A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. |
IBA |
| Domain ID | Description |
|---|---|
|
IPR012446 |
Calcium release-activated calcium channel protein |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa04020 |
Calcium signaling pathway |
KEGG |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
heart muscle |
myocytes |
|
lung |
macrophages |
|
ovary |
follicle cells |
|
smooth muscle |
smooth muscle cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
UNC119 |
9094 |
Q13432 |
0.63 |
|
SETDB1 |
9869 |
Q15047 |
0.63 |
|
MED31 |
51003 |
Q9Y3C7 |
0.63 |
|
GDF9 |
2661 |
O60383 |
0.63 |
|
COPS6 |
10980 |
Q7L5N1 |
0.63 |
|
CRACR2A |
84766 |
Q9BSW2 |
0.63 |