Protein Description

Gene Symbol ORAI2
Entrez ID 80228
Uniprot ID Q96SN7
Description ORAI calcium release-activated calcium modulator 2
Chromosomal Location chr7: 102,433,106-102,456,821
Ontology GO ID GO Term Definition Evidence

BP

GO:0002115

store-operated calcium entry

A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.

IBA

BP

GO:0070588

calcium ion transmembrane transport

A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

IEA

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IBA

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

CC

GO:0030426

growth cone

The migrating motile tip of a growing nerve cell axon or dendrite.

IEA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0015279

store-operated calcium channel activity

A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores.

IBA

Domain ID Description

IPR012446

Calcium release-activated calcium channel protein

Pathway ID Pathway Term Pathway Source

hsa04020

Calcium signaling pathway

KEGG

No diseases found.

Tissue Cell Type

adrenal gland

glandular cells

heart muscle

myocytes

lung

macrophages

ovary

follicle cells

smooth muscle

smooth muscle cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

UNC119

9094

Q13432

0.63

SETDB1

9869

Q15047

0.63

MED31

51003

Q9Y3C7

0.63

GDF9

2661

O60383

0.63

COPS6

10980

Q7L5N1

0.63

CRACR2A

84766

Q9BSW2

0.63