Protein Description

Gene Symbol ATP8B4
Entrez ID 79895
Uniprot ID Q8TF62
Description ATPase, class I, type 8B, member 4
Chromosomal Location chr15: 49,858,238-50,182,817
Ontology GO ID GO Term Definition Evidence

BP

GO:0007030

Golgi organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.

IBA

BP

GO:0045332

phospholipid translocation

The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.

IEA

CC

GO:0005794

Golgi apparatus

A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.

IDA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

MF

GO:0000287

magnesium ion binding

Interacting selectively and non-covalently with magnesium (Mg) ions.

IEA

MF

GO:0004012

phospholipid-translocating ATPase activity

Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP.

IBA

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

Domain ID Description

IPR001757

P-type ATPase

IPR006539

P-type ATPase, subfamily IV

IPR008250

P-type ATPase, A domain

IPR018303

P-type ATPase, phosphorylation site

IPR023214

HAD-like domain

IPR023298

P-type ATPase, transmembrane domain

IPR023299

P-type ATPase, cytoplasmic domain N

IPR030348

Probable phospholipid-transporting ATPase IM

IPR032630

P-type ATPase, C-terminal

IPR032631

P-type ATPase, N-terminal

No pathways found.

No diseases found.

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

breast

myoepithelial cells

bronchus

respiratory epithelial cells

caudate

neuronal cells

colon

endothelial cells

colon

glandular cells

duodenum

glandular cells

endometrium

glandular cells

gallbladder

glandular cells

lung

macrophages

nasopharynx

respiratory epithelial cells

pancreas

exocrine glandular cells

placenta

trophoblastic cells

prostate

glandular cells

rectum

glandular cells

salivary gland

glandular cells

small intestine

glandular cells

smooth muscle

smooth muscle cells

spleen

cells in red pulp

stomach

glandular cells

testis

Leydig cells

No databases found.

Pubmed ID Author Year Title

22904171

Kaur et al.

2012

Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis

Gene Symbol Entrez ID Uniprot ID Score

TMEM30B

161291

Q3MIR4

0.52

TMEM30A

55754

Q9NV96

0.65