Gene Symbol | ATP8B4 |
Entrez ID | 79895 |
Uniprot ID | Q8TF62 |
Description | ATPase, class I, type 8B, member 4 |
Chromosomal Location | chr15: 49,858,238-50,182,817 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0007030 |
Golgi organization |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. |
IBA |
BP |
GO:0045332 |
phospholipid translocation |
The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet. |
IEA |
CC |
GO:0005794 |
Golgi apparatus |
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. |
IDA |
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
IDA |
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IEA |
MF |
GO:0000287 |
magnesium ion binding |
Interacting selectively and non-covalently with magnesium (Mg) ions. |
IEA |
MF |
GO:0004012 |
phospholipid-translocating ATPase activity |
Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP. |
IBA |
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IEA |
Domain ID | Description |
---|---|
IPR001757 |
P-type ATPase |
IPR006539 |
P-type ATPase, subfamily IV |
IPR008250 |
P-type ATPase, A domain |
IPR018303 |
P-type ATPase, phosphorylation site |
IPR023214 |
HAD-like domain |
IPR023298 |
P-type ATPase, transmembrane domain |
IPR023299 |
P-type ATPase, cytoplasmic domain N |
IPR030348 |
Probable phospholipid-transporting ATPase IM |
IPR032630 |
P-type ATPase, C-terminal |
IPR032631 |
P-type ATPase, N-terminal |
Tissue | Cell Type |
---|---|
adrenal gland |
glandular cells |
appendix |
glandular cells |
breast |
myoepithelial cells |
bronchus |
respiratory epithelial cells |
caudate |
neuronal cells |
colon |
endothelial cells |
colon |
glandular cells |
duodenum |
glandular cells |
endometrium |
glandular cells |
gallbladder |
glandular cells |
lung |
macrophages |
nasopharynx |
respiratory epithelial cells |
pancreas |
exocrine glandular cells |
placenta |
trophoblastic cells |
prostate |
glandular cells |
rectum |
glandular cells |
salivary gland |
glandular cells |
small intestine |
glandular cells |
smooth muscle |
smooth muscle cells |
spleen |
cells in red pulp |
stomach |
glandular cells |
testis |
Leydig cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22904171 |
Kaur et al. |
2012 |
Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
TMEM30B |
161291 |
Q3MIR4 |
0.52 |
TMEM30A |
55754 |
Q9NV96 |
0.65 |