Protein Description

Gene Symbol MANEA
Entrez ID 79694
Uniprot ID Q5SRI9
Description mannosidase, endo-alpha
Chromosomal Location chr6: 95,577,543-95,609,457
Ontology GO ID GO Term Definition Evidence

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

TAS

CC

GO:0005794

Golgi apparatus

A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.

IDA

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

MF

GO:0004569

glycoprotein endo-alpha-1,2-mannosidase activity

Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane.

TAS

Domain ID Description

IPR017853

Glycoside hydrolase superfamily

IPR026071

Glycosyl hydrolase family 99

No pathways found.

UMLS CUI UMLS Term

C0236736

Cocaine-Related Disorders

C1456784

Paranoia

No tissues found.

Database Name

DisGeNET

Pubmed ID Author Year Title

21411543

Savaris et al.

2011

Progesterone Resistance in PCOS Endometrium: A Microarray Analysis in Clomiphene Citrate-Treated and Artificial Menstrual Cycles

Gene Symbol Entrez ID Uniprot ID Score

AMPH

273

P49418

0.63

DNM2

1785

P50570

0.56

ASGR2

433

P07307

0.63

HSD11B1

3290

P28845

0.63

PLAUR

5329

Q03405

0.63

PRD

5548

N/A

0.63

PSG1

5669

P11464

0.63

OLFM1

10439

Q99784

0.63

SIAE

54414

Q9HAT2

0.63

CPVL

54504

Q9H3G5

0.63

UGT1A10

54575

Q9HAW8

0.63

SLC39A4

55630

Q6P5W5

0.63

ANTXR1

84168

Q9H6X2

0.63

CNDP1

84735

Q96KN2

0.63