Gene Symbol | STEAP4 |
Entrez ID | 79689 |
Uniprot ID | Q687X5 |
Description | STEAP4 metalloreductase |
Chromosomal Location | chr7: 88,270,892-88,306,891 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0015677 |
copper ion import |
The directed movement of copper ions into a cell or organelle. |
IBA |
BP |
GO:0045444 |
fat cell differentiation |
The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. |
ISS |
BP |
GO:0055072 |
iron ion homeostasis |
Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell. |
IEA |
BP |
GO:0055114 |
oxidation-reduction process |
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
IEA |
BP |
GO:0097461 |
ferric iron import into cell |
The directed movement of ferric iron (Fe(III) or Fe3+) ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. |
IBA |
CC |
GO:0000139 |
Golgi membrane |
The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
IEA |
CC |
GO:0005768 |
endosome |
A vacuole to which materials ingested by endocytosis are delivered. |
IBA |
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
ISS |
CC |
GO:0005887 |
integral component of plasma membrane |
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IBA |
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
MF |
GO:0008823 |
cupric reductase activity |
Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH. |
IBA |
MF |
GO:0046872 |
metal ion binding |
Interacting selectively and non-covalently with any metal ion. |
IEA |
MF |
GO:0052851 |
ferric-chelate reductase (NADPH) activity |
Catalysis of the reaction: 2 Fe3+ + NADPH = 2 Fe2+ + H+ + NADP+ . |
IBA |
Domain ID | Description |
---|---|
IPR013130 |
Ferric reductase transmembrane component-like domain |
IPR016040 |
NAD(P)-binding domain |
IPR028939 |
Pyrroline-5-carboxylate reductase, catalytic, N-terminal |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
WP3286 |
Copper homeostasis |
WikiPathways |
UMLS CUI | UMLS Term |
---|---|
C0033578 |
Prostatic Neoplasms |
Pubmed ID | Author | Year | Title |
---|---|---|---|
23824412 |
Piltonen et al. |
2013 |
Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
AKT2 |
208 |
P31751 |
0.63 |
TERT |
7015 |
O14746 |
0.63 |