Protein Description

Gene Symbol STEAP4
Entrez ID 79689
Uniprot ID Q687X5
Description STEAP4 metalloreductase
Chromosomal Location chr7: 88,270,892-88,306,891
Ontology GO ID GO Term Definition Evidence

BP

GO:0015677

copper ion import

The directed movement of copper ions into a cell or organelle.

IBA

BP

GO:0045444

fat cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.

ISS

BP

GO:0055072

iron ion homeostasis

Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.

IEA

BP

GO:0055114

oxidation-reduction process

A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.

IEA

BP

GO:0097461

ferric iron import into cell

The directed movement of ferric iron (Fe(III) or Fe3+) ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis.

IBA

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

IEA

CC

GO:0005768

endosome

A vacuole to which materials ingested by endocytosis are delivered.

IBA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

ISS

CC

GO:0005887

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IBA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0008823

cupric reductase activity

Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH.

IBA

MF

GO:0046872

metal ion binding

Interacting selectively and non-covalently with any metal ion.

IEA

MF

GO:0052851

ferric-chelate reductase (NADPH) activity

Catalysis of the reaction: 2 Fe3+ + NADPH = 2 Fe2+ + H+ + NADP+ .

IBA

Domain ID Description

IPR013130

Ferric reductase transmembrane component-like domain

IPR016040

NAD(P)-binding domain

IPR028939

Pyrroline-5-carboxylate reductase, catalytic, N-terminal

Pathway ID Pathway Term Pathway Source

WP3286

Copper homeostasis

WikiPathways

UMLS CUI UMLS Term

C0033578

Prostatic Neoplasms

No tissues found.

No databases found.

Pubmed ID Author Year Title

23824412

Piltonen et al.

2013

Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential

Gene Symbol Entrez ID Uniprot ID Score

AKT2

208

P31751

0.63

TERT

7015

O14746

0.63