Protein Description

Gene Symbol APOO
Entrez ID 79135
Uniprot ID Q9BUR5
Description apolipoprotein O
Chromosomal Location chrX: 23,833,353-23,907,934
Ontology GO ID GO Term Definition Evidence

BP

GO:0006869

lipid transport

The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

IEA

BP

GO:0042407

cristae formation

The assembly of cristae, the inwards folds of the inner mitochondrial membrane.

IMP

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

IDA

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

IDA

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

ISS

CC

GO:0005739

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

IDA

CC

GO:0005789

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

IDA

CC

GO:0031305

integral component of mitochondrial inner membrane

The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IDA

CC

GO:0034361

very-low-density lipoprotein particle

A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver.

IEA

CC

GO:0034362

low-density lipoprotein particle

A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver.

IEA

CC

GO:0034364

high-density lipoprotein particle

A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process.

IEA

CC

GO:0061617

MICOS complex

Mitochondrial inner membrane complex involved in maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. In Saccharomyces cerevisiae the complex has six subunits: MIC10, MIC12, MIC19, MIC26, MIC27, and MIC60.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

Domain ID Description

IPR019166

MICOS complex subunit MIC26/MIC27

IPR033182

MICOS complex subunit MIC26/MIC27, animal

No pathways found.

No diseases found.

Tissue Cell Type

appendix

glandular cells

bone marrow

hematopoietic cells

bronchus

respiratory epithelial cells

cerebellum

Purkinje cells

cerebral cortex

neuronal cells

cervix, uterine

glandular cells

cervix, uterine

squamous epithelial cells

duodenum

glandular cells

endometrium

glandular cells

epididymis

glandular cells

esophagus

squamous epithelial cells

heart muscle

myocytes

nasopharynx

respiratory epithelial cells

oral mucosa

squamous epithelial cells

placenta

trophoblastic cells

rectum

glandular cells

salivary gland

glandular cells

seminal vesicle

glandular cells

skin

keratinocytes

skin

epidermal cells

small intestine

glandular cells

stomach

glandular cells

thyroid gland

glandular cells

tonsil

squamous epithelial cells

urinary bladder

urothelial cells

vagina

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

18765015

Qiao et al.

2008

Microarray evaluation of endometrial receptivity in Chinese women with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

CDK2

1017

P24941

0.63

TIMMDC1

51300

Q9NPL8

0.72