Gene Symbol | FTO |
Entrez ID | 79068 |
Uniprot ID | Q9C0B1 |
Description | fat mass and obesity associated |
Chromosomal Location | chr16: 53,701,692-54,158,512 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0001659 |
temperature homeostasis |
A homeostatic process in which an organism modulates its internal body temperature. |
IEA |
BP |
GO:0006307 |
DNA dealkylation involved in DNA repair |
The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT). |
IDA |
BP |
GO:0010883 |
regulation of lipid storage |
Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. |
IMP |
BP |
GO:0035552 |
oxidative single-stranded DNA demethylation |
Removal of the methyl group from one or more nucleotides within a single-stranded DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. |
IDA |
BP |
GO:0035553 |
oxidative single-stranded RNA demethylation |
Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. |
IDA|IMP |
BP |
GO:0040014 |
regulation of multicellular organism growth |
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. |
IEA |
BP |
GO:0042245 |
RNA repair |
Any process that results in the repair of damaged RNA. |
IDA |
BP |
GO:0044065 |
regulation of respiratory system process |
Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. |
IEA |
BP |
GO:0060612 |
adipose tissue development |
The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. |
IEA |
BP |
GO:0070350 |
regulation of white fat cell proliferation |
Any process that modulates the frequency, rate or extent of white fat cell proliferation. |
IEA |
BP |
GO:0070989 |
oxidative demethylation |
The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate. |
IDA |
BP |
GO:0080111 |
DNA demethylation |
The removal of a methyl group from one or more nucleotides within an DNA molecule. |
IDA |
BP |
GO:0090335 |
regulation of brown fat cell differentiation |
Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. |
IMP |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA|ISS |
CC |
GO:0016607 |
nuclear speck |
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
IDA |
MF |
GO:0008198 |
ferrous iron binding |
Interacting selectively and non-covalently with ferrous iron, Fe(II). |
IDA |
MF |
GO:0035515 |
oxidative RNA demethylase activity |
Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. |
IDA |
MF |
GO:0035516 |
oxidative DNA demethylase activity |
Catalysis of the removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. |
IDA |
MF |
GO:0043734 |
DNA-N1-methyladenine dioxygenase activity |
Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde. |
IDA |
MF |
GO:1990931 |
RNA N6-methyladenosine dioxygenase activity |
Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde. |
IMP |
Domain ID | Description |
---|---|
IPR024366 |
Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal |
IPR024367 |
Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain |
IPR027450 |
Alpha-ketoglutarate-dependent dioxygenase AlkB-like |
IPR032868 |
Alpha-ketoglutarate-dependent dioxygenase FTO |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
WP3407 |
FTO Obesity Variant Mechanism |
WikiPathways |
UMLS CUI | UMLS Term |
---|---|
C0005910 |
Body Weight |
C0006142 |
Malignant Neoplasm Of Breast |
C0011860 |
Diabetes Mellitus, Non-Insulin-Dependent |
C0025202 |
Melanoma |
C0028754 |
Obesity |
C0524620 |
Metabolic Syndrome X |
C1458155 |
Mammary Neoplasms |
C2607914 |
Allergic Rhinitis (Disorder) |
Tissue | Cell Type |
---|---|
adrenal gland |
glandular cells |
cerebellum |
cells in granular layer |
cervix, uterine |
glandular cells |
epididymis |
glandular cells |
nasopharynx |
respiratory epithelial cells |
pancreas |
exocrine glandular cells |
pancreas |
islets of Langerhans |
parathyroid gland |
glandular cells |
placenta |
decidual cells |
salivary gland |
glandular cells |
skeletal muscle |
myocytes |
soft tissue |
fibroblasts |
testis |
Leydig cells |
thyroid gland |
glandular cells |
Database Name |
---|
DisGeNET |
DISEASES |
DGA |
Pubmed ID | Author | Year | Title |
---|---|---|---|
12734205 |
Wood et al. |
2003 |
The Molecular Phenotype of Polycystic Ovary Syndrome (PCOS) Theca Cells and New Candidate PCOS Genes Defined by Microarray Analysis |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
CKB |
1152 |
P12277 |
0.63 |
EEF2 |
1938 |
P13639 |
0.63 |
LDHA |
3939 |
P00338 |
0.63 |
LDHB |
3945 |
P07195 |
0.63 |
MVD |
4597 |
P53602 |
0.63 |
SLC9A3R1 |
9368 |
O14745 |
0.63 |
NPEPPS |
9520 |
P55786 |
0.63 |
NDRG1 |
10397 |
Q92597 |
0.63 |
TKFC |
26007 |
Q3LXA3 |
0.63 |
CNDP2 |
55748 |
Q96KP4 |
0.63 |
BCCIP |
56647 |
Q9P287 |
0.63 |
NEDD8 |
4738 |
Q15843 |
0.63 |
PEPD |
5184 |
P12955 |
0.63 |
CTSA |
5476 |
P10619 |
0.63 |
SUMO1 |
7341 |
P63165 |
0.63 |
GABARAPL2 |
11345 |
P60520 |
0.63 |
ZMAT3 |
64393 |
Q9HA38 |
0.63 |
SLX4 |
84464 |
Q8IY92 |
0.63 |