| Gene Symbol | ALG8 |
| Entrez ID | 79053 |
| Uniprot ID | Q9BVK2 |
| Description | ALG8, alpha-1,3-glucosyltransferase |
| Chromosomal Location | chr11: 78,100,936-78,139,660 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006487 |
protein N-linked glycosylation |
A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. |
IMP |
|
BP |
GO:0006488 |
dolichol-linked oligosaccharide biosynthetic process |
The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P. |
TAS |
|
BP |
GO:0006490 |
oligosaccharide-lipid intermediate biosynthetic process |
The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation. |
IBA |
|
BP |
GO:0097502 |
mannosylation |
The covalent attachment of a mannose residue to a substrate molecule. |
IEA |
|
CC |
GO:0005789 |
endoplasmic reticulum membrane |
The lipid bilayer surrounding the endoplasmic reticulum. |
IBA|TAS |
|
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IEA |
|
MF |
GO:0000033 |
alpha-1,3-mannosyltransferase activity |
Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage. |
IMP |
|
MF |
GO:0004583 |
dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity |
Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide. |
TAS |
|
MF |
GO:0042281 |
dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity |
Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol. |
IBA |
| Domain ID | Description |
|---|---|
|
IPR004856 |
Glycosyl transferase, ALG6/ALG8 |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00510 |
N-Glycan biosynthesis |
KEGG |
|
hsa01100 |
Metabolic pathways |
KEGG |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
appendix |
lymphoid tissue |
|
bone marrow |
hematopoietic cells |
|
bronchus |
respiratory epithelial cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
Purkinje cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
hippocampus |
neuronal cells |
|
kidney |
cells in tubules |
|
liver |
hepatocytes |
|
lymph node |
germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
ovary |
follicle cells |
|
pancreas |
exocrine glandular cells |
|
parathyroid gland |
glandular cells |
|
placenta |
decidual cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
NAE1 |
8883 |
Q13564 |
0.63 |
|
RPS6KA5 |
9252 |
O75582 |
0.63 |
|
GPR52 |
9293 |
Q9Y2T5 |
0.63 |
|
TSPAN5 |
10098 |
P62079 |
0.63 |
|
NXF1 |
10482 |
Q9UBU9 |
0.63 |
|
SLC39A4 |
55630 |
Q6P5W5 |
0.63 |