Protein Description

Gene Symbol ALG8
Entrez ID 79053
Uniprot ID Q9BVK2
Description ALG8, alpha-1,3-glucosyltransferase
Chromosomal Location chr11: 78,100,936-78,139,660
Ontology GO ID GO Term Definition Evidence

BP

GO:0006487

protein N-linked glycosylation

A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan.

IMP

BP

GO:0006488

dolichol-linked oligosaccharide biosynthetic process

The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P.

TAS

BP

GO:0006490

oligosaccharide-lipid intermediate biosynthetic process

The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation.

IBA

BP

GO:0097502

mannosylation

The covalent attachment of a mannose residue to a substrate molecule.

IEA

CC

GO:0005789

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

IBA|TAS

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

MF

GO:0000033

alpha-1,3-mannosyltransferase activity

Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage.

IMP

MF

GO:0004583

dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity

Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide.

TAS

MF

GO:0042281

dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity

Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.

IBA

Domain ID Description

IPR004856

Glycosyl transferase, ALG6/ALG8

Pathway ID Pathway Term Pathway Source

hsa00510

N-Glycan biosynthesis

KEGG

hsa01100

Metabolic pathways

KEGG

No diseases found.

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

appendix

lymphoid tissue

bone marrow

hematopoietic cells

bronchus

respiratory epithelial cells

cerebellum

cells in granular layer

cerebellum

Purkinje cells

colon

glandular cells

duodenum

glandular cells

endometrium

glandular cells

esophagus

squamous epithelial cells

fallopian tube

glandular cells

gallbladder

glandular cells

hippocampus

neuronal cells

kidney

cells in tubules

liver

hepatocytes

lymph node

germinal center cells

nasopharynx

respiratory epithelial cells

oral mucosa

squamous epithelial cells

ovary

follicle cells

pancreas

exocrine glandular cells

parathyroid gland

glandular cells

placenta

decidual cells

rectum

glandular cells

salivary gland

glandular cells

skin

epidermal cells

small intestine

glandular cells

spleen

cells in white pulp

stomach

glandular cells

testis

cells in seminiferous ducts

testis

Leydig cells

tonsil

germinal center cells

tonsil

non-germinal center cells

tonsil

squamous epithelial cells

urinary bladder

urothelial cells

vagina

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

NAE1

8883

Q13564

0.63

RPS6KA5

9252

O75582

0.63

GPR52

9293

Q9Y2T5

0.63

TSPAN5

10098

P62079

0.63

NXF1

10482

Q9UBU9

0.63

SLC39A4

55630

Q6P5W5

0.63