BP

GO:0001525

angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

IEA

BP

GO:0001938

positive regulation of endothelial cell proliferation

Any process that activates or increases the rate or extent of endothelial cell proliferation.

IMP

BP

GO:0006457

protein folding

The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.

IEA

BP

GO:0006915

apoptotic process

A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.

IEA

BP

GO:0008616

queuosine biosynthetic process

The chemical reactions and pathways resulting in the formation of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents.

IBA

BP

GO:0016032

viral process

A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.

IEA

BP

GO:0045766

positive regulation of angiogenesis

Any process that activates or increases angiogenesis.

IMP

BP

GO:0050730

regulation of peptidyl-tyrosine phosphorylation

Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.

IMP

BP

GO:2000059

negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of protein ubiquitination involved in ubiquitin-dependent protein catabolic process.

IMP

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0008479

queuine tRNA-ribosyltransferase activity

Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine.

IBA

MF

GO:0043184

vascular endothelial growth factor receptor 2 binding

Interacting selectively and non-covalently with vascular endothelial growth factor receptor 2.

IEA

MF

GO:0044183

protein binding involved in protein folding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) that contributes to the process of protein folding.

IPI