Gene Symbol | NUCKS1 |
Entrez ID | 64710 |
Uniprot ID | Q9H1E3 |
Description | nuclear casein kinase and cyclin-dependent kinase substrate 1 |
Chromosomal Location | chr1: 205,712,819-205,750,276 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0000724 |
double-strand break repair via homologous recombination |
The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. |
IMP |
BP |
GO:0001678 |
cellular glucose homeostasis |
A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment. |
ISS |
BP |
GO:0006275 |
regulation of DNA replication |
Any process that modulates the frequency, rate or extent of DNA replication. |
IMP |
BP |
GO:0006325 |
chromatin organization |
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin. |
ISS |
BP |
GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IC |
BP |
GO:0006366 |
transcription from RNA polymerase II promoter |
The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). |
IEA |
BP |
GO:0019046 |
release from viral latency |
The process by which a virus switches from latency and begins to replicate. It may be effected by various endogenous and exogenous stimuli, including B-cell lipopolysaccharides, glucocorticoid hormones, halogenated pyrimidines, ionizing radiation, ultraviolet light, various chemicals and super-infecting viruses. |
IMP |
BP |
GO:0031297 |
replication fork processing |
The process in which a DNA replication fork that has stalled is to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes. |
IDA |
BP |
GO:0035822 |
gene conversion |
A DNA recombination process that results in the unidirectional transfer of genetic material from a donor sequence to a highly homologous acceptor. |
NAS |
BP |
GO:0036297 |
interstrand cross-link repair |
Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication. |
IMP |
BP |
GO:0043923 |
positive regulation by host of viral transcription |
Any process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA. |
IGI |
BP |
GO:0044829 |
positive regulation by host of viral genome replication |
A process in which a host organism activates or increases the frequency, rate or extent of viral genome replication. |
IMP |
BP |
GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IEA |
BP |
GO:0046626 |
regulation of insulin receptor signaling pathway |
Any process that modulates the frequency, rate or extent of insulin receptor signaling. |
ISS |
BP |
GO:0046628 |
positive regulation of insulin receptor signaling pathway |
Any process that increases the frequency, rate or extent of insulin receptor signaling. |
IEA |
BP |
GO:0060382 |
regulation of DNA strand elongation |
Any process that modulates the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand. |
IMP |
BP |
GO:0071481 |
cellular response to X-ray |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz). |
IMP |
BP |
GO:1990968 |
modulation by host of RNA binding by virus |
A process in which a host organism modulates the frequency, rate or extent of a viral gene product binding to RNA. |
IMP |
BP |
GO:1990969 |
modulation by host of viral RNA-binding transcription factor activity |
A process in which a host organism modulates the frequency, rate or extent of the activity of a viral RNA-binding transcription factor. |
IGI |
CC |
GO:0000785 |
chromatin |
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
ISS |
CC |
GO:0000790 |
nuclear chromatin |
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus. |
IDA |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
MF |
GO:0001077 |
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding |
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. |
IEA |
MF |
GO:0003682 |
chromatin binding |
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
IDA |
MF |
GO:0003690 |
double-stranded DNA binding |
Interacting selectively and non-covalently with double-stranded DNA. |
IDA |
MF |
GO:0008134 |
transcription factor binding |
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription. |
IPI |
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
Domain ID | Description |
---|---|
IPR026633 |
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 |
UMLS CUI | UMLS Term |
---|---|
C0030567 |
Parkinson Disease |
Tissue | Cell Type |
---|---|
adrenal gland |
glandular cells |
breast |
adipocytes |
breast |
glandular cells |
bronchus |
respiratory epithelial cells |
cerebellum |
cells in molecular layer |
cerebellum |
Purkinje cells |
cerebral cortex |
glial cells |
cerebral cortex |
neuronal cells |
cervix, uterine |
squamous epithelial cells |
epididymis |
glandular cells |
esophagus |
squamous epithelial cells |
fallopian tube |
glandular cells |
gallbladder |
glandular cells |
hippocampus |
glial cells |
kidney |
cells in glomeruli |
kidney |
cells in tubules |
liver |
bile duct cells |
liver |
hepatocytes |
lung |
pneumocytes |
oral mucosa |
squamous epithelial cells |
pancreas |
exocrine glandular cells |
pancreas |
islets of Langerhans |
parathyroid gland |
glandular cells |
placenta |
decidual cells |
prostate |
glandular cells |
salivary gland |
glandular cells |
seminal vesicle |
glandular cells |
skeletal muscle |
myocytes |
skin |
epidermal cells |
stomach |
glandular cells |
testis |
Leydig cells |
thyroid gland |
glandular cells |
urinary bladder |
urothelial cells |
vagina |
squamous epithelial cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
26459919 |
Lan et al. |
2015 |
Functional microarray analysis of differentially expressed genes in granulosa cells from women with polycystic ovary syndrome related to MAPK/ERK signaling |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
MDM2 |
4193 |
Q00987 |
0.49 |
ORC2 |
4999 |
Q13416 |
0.49 |
COPS2 |
9318 |
P61201 |
0.49 |
HUWE1 |
10075 |
Q7Z6Z7 |
0.49 |
HEXIM1 |
10614 |
O94992 |
0.49 |
PHAX |
51808 |
Q9H814 |
0.49 |
RBM42 |
79171 |
Q9BTD8 |
0.49 |
DOCK9 |
23348 |
Q9BZ29 |
0.63 |
EWSR1 |
2130 |
Q01844 |
0.49 |
HMGB3 |
3149 |
O15347 |
0.49 |
ILF3 |
3609 |
Q12906 |
0.49 |
RBMX |
27316 |
P38159 |
0.49 |
ELAVL1 |
1994 |
Q15717 |
0.63 |
PRCP |
5547 |
P42785 |
0.63 |
AK5 |
26289 |
Q9Y6K8 |
0.63 |
GLP1R |
2740 |
P43220 |
0.72 |
MME |
4311 |
P08473 |
0.72 |