BP

GO:0000724

double-strand break repair via homologous recombination

The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.

IMP

BP

GO:0001678

cellular glucose homeostasis

A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment.

ISS

BP

GO:0006275

regulation of DNA replication

Any process that modulates the frequency, rate or extent of DNA replication.

IMP

BP

GO:0006325

chromatin organization

Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.

ISS

BP

GO:0006357

regulation of transcription from RNA polymerase II promoter

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IC

BP

GO:0006366

transcription from RNA polymerase II promoter

The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

IEA

BP

GO:0019046

release from viral latency

The process by which a virus switches from latency and begins to replicate. It may be effected by various endogenous and exogenous stimuli, including B-cell lipopolysaccharides, glucocorticoid hormones, halogenated pyrimidines, ionizing radiation, ultraviolet light, various chemicals and super-infecting viruses.

IMP

BP

GO:0031297

replication fork processing

The process in which a DNA replication fork that has stalled is to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes.

IDA

BP

GO:0035822

gene conversion

A DNA recombination process that results in the unidirectional transfer of genetic material from a donor sequence to a highly homologous acceptor.

NAS

BP

GO:0036297

interstrand cross-link repair

Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication.

IMP

BP

GO:0043923

positive regulation by host of viral transcription

Any process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA.

IGI

BP

GO:0044829

positive regulation by host of viral genome replication

A process in which a host organism activates or increases the frequency, rate or extent of viral genome replication.

IMP

BP

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IEA

BP

GO:0046626

regulation of insulin receptor signaling pathway

Any process that modulates the frequency, rate or extent of insulin receptor signaling.

ISS

BP

GO:0046628

positive regulation of insulin receptor signaling pathway

Any process that increases the frequency, rate or extent of insulin receptor signaling.

IEA

BP

GO:0060382

regulation of DNA strand elongation

Any process that modulates the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand.

IMP

BP

GO:0071481

cellular response to X-ray

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz).

IMP

BP

GO:1990968

modulation by host of RNA binding by virus

A process in which a host organism modulates the frequency, rate or extent of a viral gene product binding to RNA.

IMP

BP

GO:1990969

modulation by host of viral RNA-binding transcription factor activity

A process in which a host organism modulates the frequency, rate or extent of the activity of a viral RNA-binding transcription factor.

IGI

CC

GO:0000785

chromatin

The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.

ISS

CC

GO:0000790

nuclear chromatin

The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.

IDA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

MF

GO:0001077

transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding

Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.

IEA

MF

GO:0003682

chromatin binding

Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.

IDA

MF

GO:0003690

double-stranded DNA binding

Interacting selectively and non-covalently with double-stranded DNA.

IDA

MF

GO:0008134

transcription factor binding

Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.

IPI

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA