Protein Description

Gene Symbol NUCKS1
Entrez ID 64710
Uniprot ID Q9H1E3
Description nuclear casein kinase and cyclin-dependent kinase substrate 1
Chromosomal Location chr1: 205,712,819-205,750,276
Ontology GO ID GO Term Definition Evidence

BP

GO:0000724

double-strand break repair via homologous recombination

The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.

IMP

BP

GO:0001678

cellular glucose homeostasis

A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment.

ISS

BP

GO:0006275

regulation of DNA replication

Any process that modulates the frequency, rate or extent of DNA replication.

IMP

BP

GO:0006325

chromatin organization

Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.

ISS

BP

GO:0006357

regulation of transcription from RNA polymerase II promoter

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IC

BP

GO:0006366

transcription from RNA polymerase II promoter

The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

IEA

BP

GO:0019046

release from viral latency

The process by which a virus switches from latency and begins to replicate. It may be effected by various endogenous and exogenous stimuli, including B-cell lipopolysaccharides, glucocorticoid hormones, halogenated pyrimidines, ionizing radiation, ultraviolet light, various chemicals and super-infecting viruses.

IMP

BP

GO:0031297

replication fork processing

The process in which a DNA replication fork that has stalled is to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes.

IDA

BP

GO:0035822

gene conversion

A DNA recombination process that results in the unidirectional transfer of genetic material from a donor sequence to a highly homologous acceptor.

NAS

BP

GO:0036297

interstrand cross-link repair

Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication.

IMP

BP

GO:0043923

positive regulation by host of viral transcription

Any process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA.

IGI

BP

GO:0044829

positive regulation by host of viral genome replication

A process in which a host organism activates or increases the frequency, rate or extent of viral genome replication.

IMP

BP

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IEA

BP

GO:0046626

regulation of insulin receptor signaling pathway

Any process that modulates the frequency, rate or extent of insulin receptor signaling.

ISS

BP

GO:0046628

positive regulation of insulin receptor signaling pathway

Any process that increases the frequency, rate or extent of insulin receptor signaling.

IEA

BP

GO:0060382

regulation of DNA strand elongation

Any process that modulates the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand.

IMP

BP

GO:0071481

cellular response to X-ray

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz).

IMP

BP

GO:1990968

modulation by host of RNA binding by virus

A process in which a host organism modulates the frequency, rate or extent of a viral gene product binding to RNA.

IMP

BP

GO:1990969

modulation by host of viral RNA-binding transcription factor activity

A process in which a host organism modulates the frequency, rate or extent of the activity of a viral RNA-binding transcription factor.

IGI

CC

GO:0000785

chromatin

The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.

ISS

CC

GO:0000790

nuclear chromatin

The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.

IDA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

MF

GO:0001077

transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding

Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.

IEA

MF

GO:0003682

chromatin binding

Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.

IDA

MF

GO:0003690

double-stranded DNA binding

Interacting selectively and non-covalently with double-stranded DNA.

IDA

MF

GO:0008134

transcription factor binding

Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.

IPI

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA

Domain ID Description

IPR026633

Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

No pathways found.

UMLS CUI UMLS Term

C0030567

Parkinson Disease

Tissue Cell Type

adrenal gland

glandular cells

breast

adipocytes

breast

glandular cells

bronchus

respiratory epithelial cells

cerebellum

cells in molecular layer

cerebellum

Purkinje cells

cerebral cortex

glial cells

cerebral cortex

neuronal cells

cervix, uterine

squamous epithelial cells

epididymis

glandular cells

esophagus

squamous epithelial cells

fallopian tube

glandular cells

gallbladder

glandular cells

hippocampus

glial cells

kidney

cells in glomeruli

kidney

cells in tubules

liver

bile duct cells

liver

hepatocytes

lung

pneumocytes

oral mucosa

squamous epithelial cells

pancreas

exocrine glandular cells

pancreas

islets of Langerhans

parathyroid gland

glandular cells

placenta

decidual cells

prostate

glandular cells

salivary gland

glandular cells

seminal vesicle

glandular cells

skeletal muscle

myocytes

skin

epidermal cells

stomach

glandular cells

testis

Leydig cells

thyroid gland

glandular cells

urinary bladder

urothelial cells

vagina

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

26459919

Lan et al.

2015

Functional microarray analysis of differentially expressed genes in granulosa cells from women with polycystic ovary syndrome related to MAPK/ERK signaling

Gene Symbol Entrez ID Uniprot ID Score

MDM2

4193

Q00987

0.49

ORC2

4999

Q13416

0.49

COPS2

9318

P61201

0.49

HUWE1

10075

Q7Z6Z7

0.49

HEXIM1

10614

O94992

0.49

PHAX

51808

Q9H814

0.49

RBM42

79171

Q9BTD8

0.49

DOCK9

23348

Q9BZ29

0.63

EWSR1

2130

Q01844

0.49

HMGB3

3149

O15347

0.49

ILF3

3609

Q12906

0.49

RBMX

27316

P38159

0.49

ELAVL1

1994

Q15717

0.63

PRCP

5547

P42785

0.63

AK5

26289

Q9Y6K8

0.63

GLP1R

2740

P43220

0.72

MME

4311

P08473

0.72