| Gene Symbol | COPS7B |
| Entrez ID | 64708 |
| Uniprot ID | Q9H9Q2 |
| Description | COP9 signalosome subunit 7B |
| Chromosomal Location | chr2: 231,781,671-231,809,254 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0000715 | nucleotide-excision repair, DNA damage recognition |
The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix. | TAS |
BP | GO:0006283 | transcription-coupled nucleotide-excision repair |
The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway. | TAS |
BP | GO:0010388 | cullin deneddylation |
The modification of cullins by removal of ubiquitin-like protein NEDD8 (RUB1). | IDA |
CC | GO:0005654 | nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. | IDA|TAS |
CC | GO:0005737 | cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | IEA |
CC | GO:0008180 | COP9 signalosome |
A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. | IDA |
| Domain ID | Description |
|---|---|
IPR000717 | Proteasome component (PCI) domain |
IPR027530 | COP9 signalosome complex subunit 7b |
| Tissue | Cell Type |
|---|---|
adrenal gland | glandular cells |
appendix | glandular cells |
bone marrow | hematopoietic cells |
breast | glandular cells |
breast | myoepithelial cells |
bronchus | respiratory epithelial cells |
cerebral cortex | neuropil |
colon | endothelial cells |
colon | glandular cells |
colon | peripheral nerve/ganglion |
duodenum | glandular cells |
endometrium | glandular cells |
epididymis | glandular cells |
esophagus | squamous epithelial cells |
fallopian tube | glandular cells |
gallbladder | glandular cells |
heart muscle | myocytes |
kidney | cells in tubules |
liver | hepatocytes |
lung | macrophages |
lung | pneumocytes |
nasopharynx | respiratory epithelial cells |
ovary | follicle cells |
pancreas | exocrine glandular cells |
pancreas | islets of Langerhans |
parathyroid gland | glandular cells |
placenta | trophoblastic cells |
prostate | glandular cells |
rectum | glandular cells |
seminal vesicle | glandular cells |
skeletal muscle | myocytes |
skin | epidermal cells |
small intestine | glandular cells |
smooth muscle | smooth muscle cells |
soft tissue | fibroblasts |
spleen | cells in red pulp |
spleen | cells in white pulp |
stomach | glandular cells |
testis | Leydig cells |
thyroid gland | glandular cells |
tonsil | germinal center cells |
tonsil | non-germinal center cells |
tonsil | squamous epithelial cells |
urinary bladder | urothelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
17148555 | Wood et al. | 2007 | Molecular Abnormalities in Oocytes from Women with Polycystic Ovary Syndrome Revealed by Microarray Analysis |
22951915 | Haozi et al. | 2012 | Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
APP | 351 | P05067 | 0.56 |
EIF3E | 3646 | P60228 | 0.62 |
HEXIM1 | 10614 | O94992 | 0.63 |
USP24 | 23358 | Q9UPU5 | 0.63 |
COPS7A | 50813 | Q9UBW8 | 0.63 |
EWSR1 | 2130 | Q01844 | 0.49 |
DDB2 | 1643 | Q92466 | 0.63 |
ELAVL1 | 1994 | Q15717 | 0.63 |
PRMT1 | 3276 | Q99873 | 0.63 |
IRF5 | 3663 | Q13568 | 0.63 |
NEDD8 | 4738 | Q15843 | 0.63 |
FBXW4 | 6468 | P57775 | 0.63 |
CUL5 | 8065 | Q93034 | 0.63 |
CUL4B | 8450 | Q13620 | 0.63 |
CUL3 | 8452 | Q13618 | 0.63 |
CUL2 | 8453 | Q13617 | 0.63 |
CUL1 | 8454 | Q13616 | 0.63 |
NMI | 9111 | Q13287 | 0.63 |
VPRBP | 9730 | Q9Y4B6 | 0.63 |
PMF1 | 11243 | Q6P1K2 | 0.63 |
FBXO6 | 26270 | Q9NRD1 | 0.63 |
DCUN1D1 | 54165 | Q96GG9 | 0.63 |
RFWD2 | 64326 | Q8NHY2 | 0.63 |
DDA1 | 79016 | Q9BW61 | 0.63 |
FBXO17 | 115290 | Q96EF6 | 0.63 |
LRR1 | 122769 | Q96L50 | 0.63 |
COPS8 | 10920 | Q99627 | 0.65 |
KRAS | 3845 | P01116 | 0.72 |
PPIA | 5478 | P62937 | 0.72 |
YWHAZ | 7534 | P63104 | 0.72 |
CDK2AP1 | 8099 | O14519 | 0.72 |
ERP44 | 23071 | Q9BS26 | 0.72 |
MYH7B | 57644 | A7E2Y1 | 0.72 |
DDB1 | 100290337 | Q16531 | 0.73 |
CUL4A | 8451 | Q13619 | 0.74 |
COPS3 | 8533 | Q9UNS2 | 0.74 |
COPS2 | 9318 | P61201 | 0.74 |
COPS4 | 51138 | Q9BT78 | 0.74 |
GPS1 | 2873 | Q13098 | 0.76 |
COPS6 | 10980 | Q7L5N1 | 0.87 |
COPS5 | 10987 | Q92905 | 0.89 |