| Gene Symbol | COPS7B |
| Entrez ID | 64708 |
| Uniprot ID | Q9H9Q2 |
| Description | COP9 signalosome subunit 7B |
| Chromosomal Location | chr2: 231,781,671-231,809,254 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0000715 |
nucleotide-excision repair, DNA damage recognition |
The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix. |
TAS |
|
BP |
GO:0006283 |
transcription-coupled nucleotide-excision repair |
The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway. |
TAS |
|
BP |
GO:0010388 |
cullin deneddylation |
The modification of cullins by removal of ubiquitin-like protein NEDD8 (RUB1). |
IDA |
|
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
IDA|TAS |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IEA |
|
CC |
GO:0008180 |
COP9 signalosome |
A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. |
IDA |
| Domain ID | Description |
|---|---|
|
IPR000717 |
Proteasome component (PCI) domain |
|
IPR027530 |
COP9 signalosome complex subunit 7b |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
bone marrow |
hematopoietic cells |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
bronchus |
respiratory epithelial cells |
|
cerebral cortex |
neuropil |
|
colon |
endothelial cells |
|
colon |
glandular cells |
|
colon |
peripheral nerve/ganglion |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
kidney |
cells in tubules |
|
liver |
hepatocytes |
|
lung |
macrophages |
|
lung |
pneumocytes |
|
nasopharynx |
respiratory epithelial cells |
|
ovary |
follicle cells |
|
pancreas |
exocrine glandular cells |
|
pancreas |
islets of Langerhans |
|
parathyroid gland |
glandular cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skeletal muscle |
myocytes |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
smooth muscle |
smooth muscle cells |
|
soft tissue |
fibroblasts |
|
spleen |
cells in red pulp |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
17148555 |
Wood et al. |
2007 |
Molecular Abnormalities in Oocytes from Women with Polycystic Ovary Syndrome Revealed by Microarray Analysis |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
APP |
351 |
P05067 |
0.56 |
|
EIF3E |
3646 |
P60228 |
0.62 |
|
HEXIM1 |
10614 |
O94992 |
0.63 |
|
USP24 |
23358 |
Q9UPU5 |
0.63 |
|
COPS7A |
50813 |
Q9UBW8 |
0.63 |
|
EWSR1 |
2130 |
Q01844 |
0.49 |
|
DDB2 |
1643 |
Q92466 |
0.63 |
|
ELAVL1 |
1994 |
Q15717 |
0.63 |
|
PRMT1 |
3276 |
Q99873 |
0.63 |
|
IRF5 |
3663 |
Q13568 |
0.63 |
|
NEDD8 |
4738 |
Q15843 |
0.63 |
|
FBXW4 |
6468 |
P57775 |
0.63 |
|
CUL5 |
8065 |
Q93034 |
0.63 |
|
CUL4B |
8450 |
Q13620 |
0.63 |
|
CUL3 |
8452 |
Q13618 |
0.63 |
|
CUL2 |
8453 |
Q13617 |
0.63 |
|
CUL1 |
8454 |
Q13616 |
0.63 |
|
NMI |
9111 |
Q13287 |
0.63 |
|
VPRBP |
9730 |
Q9Y4B6 |
0.63 |
|
PMF1 |
11243 |
Q6P1K2 |
0.63 |
|
FBXO6 |
26270 |
Q9NRD1 |
0.63 |
|
DCUN1D1 |
54165 |
Q96GG9 |
0.63 |
|
RFWD2 |
64326 |
Q8NHY2 |
0.63 |
|
DDA1 |
79016 |
Q9BW61 |
0.63 |
|
FBXO17 |
115290 |
Q96EF6 |
0.63 |
|
LRR1 |
122769 |
Q96L50 |
0.63 |
|
COPS8 |
10920 |
Q99627 |
0.65 |
|
KRAS |
3845 |
P01116 |
0.72 |
|
PPIA |
5478 |
P62937 |
0.72 |
|
YWHAZ |
7534 |
P63104 |
0.72 |
|
CDK2AP1 |
8099 |
O14519 |
0.72 |
|
ERP44 |
23071 |
Q9BS26 |
0.72 |
|
MYH7B |
57644 |
A7E2Y1 |
0.72 |
|
DDB1 |
100290337 |
Q16531 |
0.73 |
|
CUL4A |
8451 |
Q13619 |
0.74 |
|
COPS3 |
8533 |
Q9UNS2 |
0.74 |
|
COPS2 |
9318 |
P61201 |
0.74 |
|
COPS4 |
51138 |
Q9BT78 |
0.74 |
|
GPS1 |
2873 |
Q13098 |
0.76 |
|
COPS6 |
10980 |
Q7L5N1 |
0.87 |
|
COPS5 |
10987 |
Q92905 |
0.89 |