Protein Description

Gene Symbol XYLT2
Entrez ID 64132
Uniprot ID Q9H1B5
Description xylosyltransferase II
Chromosomal Location chr17: 50,346,092-50,363,138
Ontology GO ID GO Term Definition Evidence

BP

GO:0006024

glycosaminoglycan biosynthetic process

The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.

NAS

BP

GO:0015012

heparan sulfate proteoglycan biosynthetic process

The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.

IEA|IMP

BP

GO:0030206

chondroitin sulfate biosynthetic process

The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.

IEA

BP

GO:0030210

heparin biosynthetic process

The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.

IEA

BP

GO:0050650

chondroitin sulfate proteoglycan biosynthetic process

The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.

IMP

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

IEA

CC

GO:0005575

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

ND

CC

GO:0005789

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

IEA

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

MF

GO:0008375

acetylglucosaminyltransferase activity

Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar.

IEA

MF

GO:0030158

protein xylosyltransferase activity

Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate.

NAS

Domain ID Description

IPR003406

Glycosyl transferase, family 14

IPR024448

Xylosyltransferase

Pathway ID Pathway Term Pathway Source

hsa00532

Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

KEGG

hsa00534

Glycosaminoglycan biosynthesis - heparan sulfate / heparin

KEGG

hsa01100

Metabolic pathways

KEGG

UMLS CUI UMLS Term

C0033847

Pseudoxanthoma Elasticum

No tissues found.

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

IDS

3423

P22304

0.63

TAZ

6901

Q16635

0.63

CAMK1

8536

Q14012

0.63

B4GALT3

8703

O60512

0.63

CAMK1D

57118

Q8IU85

0.63

POMK

84197

Q9H5K3

0.63

FAM134C

162427

Q86VR2

0.63