| Gene Symbol | XYLT2 |
| Entrez ID | 64132 |
| Uniprot ID | Q9H1B5 |
| Description | xylosyltransferase II |
| Chromosomal Location | chr17: 50,346,092-50,363,138 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0006024 | glycosaminoglycan biosynthetic process |
The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. | NAS |
BP | GO:0015012 | heparan sulfate proteoglycan biosynthetic process |
The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues. | IEA|IMP |
BP | GO:0030206 | chondroitin sulfate biosynthetic process |
The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. | IEA |
BP | GO:0030210 | heparin biosynthetic process |
The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. | IEA |
BP | GO:0050650 | chondroitin sulfate proteoglycan biosynthetic process |
The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. | IMP |
CC | GO:0000139 | Golgi membrane |
The lipid bilayer surrounding any of the compartments of the Golgi apparatus. | IEA |
CC | GO:0005575 | cellular_component |
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. | ND |
CC | GO:0005789 | endoplasmic reticulum membrane |
The lipid bilayer surrounding the endoplasmic reticulum. | IEA |
CC | GO:0016021 | integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. | IEA |
MF | GO:0008375 | acetylglucosaminyltransferase activity |
Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. | IEA |
MF | GO:0030158 | protein xylosyltransferase activity |
Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate. | NAS |
| Domain ID | Description |
|---|---|
IPR003406 | Glycosyl transferase, family 14 |
IPR024448 | Xylosyltransferase |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
hsa00532 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | KEGG |
hsa00534 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin | KEGG |
hsa01100 | Metabolic pathways | KEGG |
| UMLS CUI | UMLS Term |
|---|---|
C0033847 | Pseudoxanthoma Elasticum |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
22951915 | Haozi et al. | 2012 | Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
IDS | 3423 | P22304 | 0.63 |
TAZ | 6901 | Q16635 | 0.63 |
CAMK1 | 8536 | Q14012 | 0.63 |
B4GALT3 | 8703 | O60512 | 0.63 |
CAMK1D | 57118 | Q8IU85 | 0.63 |
POMK | 84197 | Q9H5K3 | 0.63 |
FAM134C | 162427 | Q86VR2 | 0.63 |