Protein Description

Gene Symbol ADSS
Entrez ID 159
Uniprot ID P30520
Description adenylosuccinate synthase
Chromosomal Location chr1: 244,408,494-244,452,134
Ontology GO ID GO Term Definition Evidence

BP

GO:0002376

immune system process

Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

NAS

BP

GO:0006167

AMP biosynthetic process

The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate.

IDA|NAS

BP

GO:0006531

aspartate metabolic process

The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.

IEA

BP

GO:0009168

purine ribonucleoside monophosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.

TAS

BP

GO:0014074

response to purine-containing compound

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus.

IEA

BP

GO:0044208

de novo' AMP biosynthetic process

The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP).

IBA|IEA

BP

GO:0046040

IMP metabolic process

The chemical reactions and pathways involving IMP, inosine monophosphate.

IBA

BP

GO:0060359

response to ammonium ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus.

IEA

BP

GO:0071257

cellular response to electrical stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.

IEA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IBA|IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0000287

magnesium ion binding

Interacting selectively and non-covalently with magnesium (Mg) ions.

IEA

MF

GO:0004019

adenylosuccinate synthase activity

Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate.

EXP|IDA|NAS

MF

GO:0005525

GTP binding

Interacting selectively and non-covalently with GTP, guanosine triphosphate.

NAS

MF

GO:0042301

phosphate ion binding

Interacting selectively and non-covalently with phosphate.

NAS

Domain ID Description

IPR001114

Adenylosuccinate synthetase

IPR018220

Adenylosuccinate synthase, GTP-binding site

IPR027417

P-loop containing nucleoside triphosphate hydrolase

IPR027529

Adenylosuccinate synthetase isozyme 2, chordates

IPR033128

Adenylosuccinate synthase, active site

Pathway ID Pathway Term Pathway Source

hsa00230

Purine metabolism

KEGG

hsa00250

Alanine, aspartate and glutamate metabolism

KEGG

hsa01100

Metabolic pathways

KEGG

WP404

Nucleotide Metabolism

WikiPathways

UMLS CUI UMLS Term

C0017661

Iga Glomerulonephritis

Tissue Cell Type

placenta

decidual cells

No databases found.

Pubmed ID Author Year Title

26459919

Lan et al.

2015

Functional microarray analysis of differentially expressed genes in granulosa cells from women with polycystic ovary syndrome related to MAPK/ERK signaling

Gene Symbol Entrez ID Uniprot ID Score

AGL

178

P35573

0.49

HSD17B10

3028

Q99714

0.49

IMPA2

3613

O14732

0.49

NME2

4831

P22392

0.49

PCBD1

5092

P61457

0.49

PFKL

5211

P17858

0.49

RNH1

6050

P13489

0.49

RPE

6120

Q96AT9

0.49

SGTA

6449

O43765

0.49

UMPS

7372

P11172

0.49

ARFIP1

27236

P53367

0.49

AASDHPPT

60496

Q9NRN7

0.49

GNPNAT1

64841

Q96EK6

0.49

ARMT1

79624

Q9H993

0.49

TANGO2

128989

Q6ICL3

0.49

ACTA1

58

P68133

0.52

GART

2618

P22102

0.56

FDPS

2224

P14324

0.63

PDIA3

2923

P30101

0.63

HSPE1

3336

P61604

0.63

PTMS

5763

P20962

0.63

RBBP7

5931

Q16576

0.63

TALDO1

6888

P37837

0.63

KYNU

8942

Q16719

0.63

WDR1

9948

O75083

0.63

CTBP1

1487

Q13363

0.49

OAT

4942

P04181

0.49

ANXA6

309

P08133

0.63

MAPK14

1432

Q16539

0.63

DCK

1633

P27707

0.63

GSR

2936

P00390

0.63

HLA-B

3106

P30480

0.63

IDH1

3417

O75874

0.63

OXCT1

5019

P55809

0.63

SUMO2

6613

P61956

0.63

THOP1

7064

P52888

0.63

CUL3

8452

Q13618

0.63

IKBKE

9641

Q14164

0.63

CBX3

11335

Q13185

0.63

CHMP4A

29082

Q9BY43

0.63

CHRAC1

54108

Q9NRG0

0.63

OTUB1

55611

Q96FW1

0.63

ATG10

83734

Q9H0Y0

0.63

SMYD1

150572

Q8NB12

0.76