| Gene Symbol | ADSS |
| Entrez ID | 159 |
| Uniprot ID | P30520 |
| Description | adenylosuccinate synthase |
| Chromosomal Location | chr1: 244,408,494-244,452,134 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0002376 | immune system process |
Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. | NAS |
BP | GO:0006167 | AMP biosynthetic process |
The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate. | IDA|NAS |
BP | GO:0006531 | aspartate metabolic process |
The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. | IEA |
BP | GO:0009168 | purine ribonucleoside monophosphate biosynthetic process |
The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar. | TAS |
BP | GO:0014074 | response to purine-containing compound |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus. | IEA |
BP | GO:0044208 | de novo' AMP biosynthetic process |
The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP). | IBA|IEA |
BP | GO:0046040 | IMP metabolic process |
The chemical reactions and pathways involving IMP, inosine monophosphate. | IBA |
BP | GO:0060359 | response to ammonium ion |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus. | IEA |
BP | GO:0071257 | cellular response to electrical stimulus |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. | IEA |
CC | GO:0005737 | cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | IBA|IDA |
CC | GO:0005829 | cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. | TAS |
CC | GO:0005886 | plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. | IDA |
CC | GO:0070062 | extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. | IDA |
MF | GO:0000287 | magnesium ion binding |
Interacting selectively and non-covalently with magnesium (Mg) ions. | IEA |
MF | GO:0004019 | adenylosuccinate synthase activity |
Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate. | EXP|IDA|NAS |
MF | GO:0005525 | GTP binding |
Interacting selectively and non-covalently with GTP, guanosine triphosphate. | NAS |
MF | GO:0042301 | phosphate ion binding |
Interacting selectively and non-covalently with phosphate. | NAS |
| Domain ID | Description |
|---|---|
IPR001114 | Adenylosuccinate synthetase |
IPR018220 | Adenylosuccinate synthase, GTP-binding site |
IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
IPR027529 | Adenylosuccinate synthetase isozyme 2, chordates |
IPR033128 | Adenylosuccinate synthase, active site |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
hsa00230 | Purine metabolism | KEGG |
hsa00250 | Alanine, aspartate and glutamate metabolism | KEGG |
hsa01100 | Metabolic pathways | KEGG |
WP404 | Nucleotide Metabolism | WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
C0017661 | Iga Glomerulonephritis |
| Tissue | Cell Type |
|---|---|
placenta | decidual cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
26459919 | Lan et al. | 2015 | Functional microarray analysis of differentially expressed genes in granulosa cells from women with polycystic ovary syndrome related to MAPK/ERK signaling |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
AGL | 178 | P35573 | 0.49 |
HSD17B10 | 3028 | Q99714 | 0.49 |
IMPA2 | 3613 | O14732 | 0.49 |
NME2 | 4831 | P22392 | 0.49 |
PCBD1 | 5092 | P61457 | 0.49 |
PFKL | 5211 | P17858 | 0.49 |
RNH1 | 6050 | P13489 | 0.49 |
RPE | 6120 | Q96AT9 | 0.49 |
SGTA | 6449 | O43765 | 0.49 |
UMPS | 7372 | P11172 | 0.49 |
ARFIP1 | 27236 | P53367 | 0.49 |
AASDHPPT | 60496 | Q9NRN7 | 0.49 |
GNPNAT1 | 64841 | Q96EK6 | 0.49 |
ARMT1 | 79624 | Q9H993 | 0.49 |
TANGO2 | 128989 | Q6ICL3 | 0.49 |
ACTA1 | 58 | P68133 | 0.52 |
GART | 2618 | P22102 | 0.56 |
FDPS | 2224 | P14324 | 0.63 |
PDIA3 | 2923 | P30101 | 0.63 |
HSPE1 | 3336 | P61604 | 0.63 |
PTMS | 5763 | P20962 | 0.63 |
RBBP7 | 5931 | Q16576 | 0.63 |
TALDO1 | 6888 | P37837 | 0.63 |
KYNU | 8942 | Q16719 | 0.63 |
WDR1 | 9948 | O75083 | 0.63 |
CTBP1 | 1487 | Q13363 | 0.49 |
OAT | 4942 | P04181 | 0.49 |
ANXA6 | 309 | P08133 | 0.63 |
MAPK14 | 1432 | Q16539 | 0.63 |
DCK | 1633 | P27707 | 0.63 |
GSR | 2936 | P00390 | 0.63 |
HLA-B | 3106 | P30480 | 0.63 |
IDH1 | 3417 | O75874 | 0.63 |
OXCT1 | 5019 | P55809 | 0.63 |
SUMO2 | 6613 | P61956 | 0.63 |
THOP1 | 7064 | P52888 | 0.63 |
CUL3 | 8452 | Q13618 | 0.63 |
IKBKE | 9641 | Q14164 | 0.63 |
CBX3 | 11335 | Q13185 | 0.63 |
CHMP4A | 29082 | Q9BY43 | 0.63 |
CHRAC1 | 54108 | Q9NRG0 | 0.63 |
OTUB1 | 55611 | Q96FW1 | 0.63 |
ATG10 | 83734 | Q9H0Y0 | 0.63 |
SMYD1 | 150572 | Q8NB12 | 0.76 |