| Gene Symbol | ADSS |
| Entrez ID | 159 |
| Uniprot ID | P30520 |
| Description | adenylosuccinate synthase |
| Chromosomal Location | chr1: 244,408,494-244,452,134 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0002376 |
immune system process |
Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. |
NAS |
|
BP |
GO:0006167 |
AMP biosynthetic process |
The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate. |
IDA|NAS |
|
BP |
GO:0006531 |
aspartate metabolic process |
The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. |
IEA |
|
BP |
GO:0009168 |
purine ribonucleoside monophosphate biosynthetic process |
The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar. |
TAS |
|
BP |
GO:0014074 |
response to purine-containing compound |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus. |
IEA |
|
BP |
GO:0044208 |
de novo' AMP biosynthetic process |
The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP). |
IBA|IEA |
|
BP |
GO:0046040 |
IMP metabolic process |
The chemical reactions and pathways involving IMP, inosine monophosphate. |
IBA |
|
BP |
GO:0060359 |
response to ammonium ion |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus. |
IEA |
|
BP |
GO:0071257 |
cellular response to electrical stimulus |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. |
IEA |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IBA|IDA |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
|
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
IDA |
|
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
|
MF |
GO:0000287 |
magnesium ion binding |
Interacting selectively and non-covalently with magnesium (Mg) ions. |
IEA |
|
MF |
GO:0004019 |
adenylosuccinate synthase activity |
Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate. |
EXP|IDA|NAS |
|
MF |
GO:0005525 |
GTP binding |
Interacting selectively and non-covalently with GTP, guanosine triphosphate. |
NAS |
|
MF |
GO:0042301 |
phosphate ion binding |
Interacting selectively and non-covalently with phosphate. |
NAS |
| Domain ID | Description |
|---|---|
|
IPR001114 |
Adenylosuccinate synthetase |
|
IPR018220 |
Adenylosuccinate synthase, GTP-binding site |
|
IPR027417 |
P-loop containing nucleoside triphosphate hydrolase |
|
IPR027529 |
Adenylosuccinate synthetase isozyme 2, chordates |
|
IPR033128 |
Adenylosuccinate synthase, active site |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00230 |
Purine metabolism |
KEGG |
|
hsa00250 |
Alanine, aspartate and glutamate metabolism |
KEGG |
|
hsa01100 |
Metabolic pathways |
KEGG |
|
WP404 |
Nucleotide Metabolism |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0017661 |
Iga Glomerulonephritis |
| Tissue | Cell Type |
|---|---|
|
placenta |
decidual cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
26459919 |
Lan et al. |
2015 |
Functional microarray analysis of differentially expressed genes in granulosa cells from women with polycystic ovary syndrome related to MAPK/ERK signaling |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
AGL |
178 |
P35573 |
0.49 |
|
HSD17B10 |
3028 |
Q99714 |
0.49 |
|
IMPA2 |
3613 |
O14732 |
0.49 |
|
NME2 |
4831 |
P22392 |
0.49 |
|
PCBD1 |
5092 |
P61457 |
0.49 |
|
PFKL |
5211 |
P17858 |
0.49 |
|
RNH1 |
6050 |
P13489 |
0.49 |
|
RPE |
6120 |
Q96AT9 |
0.49 |
|
SGTA |
6449 |
O43765 |
0.49 |
|
UMPS |
7372 |
P11172 |
0.49 |
|
ARFIP1 |
27236 |
P53367 |
0.49 |
|
AASDHPPT |
60496 |
Q9NRN7 |
0.49 |
|
GNPNAT1 |
64841 |
Q96EK6 |
0.49 |
|
ARMT1 |
79624 |
Q9H993 |
0.49 |
|
TANGO2 |
128989 |
Q6ICL3 |
0.49 |
|
ACTA1 |
58 |
P68133 |
0.52 |
|
GART |
2618 |
P22102 |
0.56 |
|
FDPS |
2224 |
P14324 |
0.63 |
|
PDIA3 |
2923 |
P30101 |
0.63 |
|
HSPE1 |
3336 |
P61604 |
0.63 |
|
PTMS |
5763 |
P20962 |
0.63 |
|
RBBP7 |
5931 |
Q16576 |
0.63 |
|
TALDO1 |
6888 |
P37837 |
0.63 |
|
KYNU |
8942 |
Q16719 |
0.63 |
|
WDR1 |
9948 |
O75083 |
0.63 |
|
CTBP1 |
1487 |
Q13363 |
0.49 |
|
OAT |
4942 |
P04181 |
0.49 |
|
ANXA6 |
309 |
P08133 |
0.63 |
|
MAPK14 |
1432 |
Q16539 |
0.63 |
|
DCK |
1633 |
P27707 |
0.63 |
|
GSR |
2936 |
P00390 |
0.63 |
|
HLA-B |
3106 |
P30480 |
0.63 |
|
IDH1 |
3417 |
O75874 |
0.63 |
|
OXCT1 |
5019 |
P55809 |
0.63 |
|
SUMO2 |
6613 |
P61956 |
0.63 |
|
THOP1 |
7064 |
P52888 |
0.63 |
|
CUL3 |
8452 |
Q13618 |
0.63 |
|
IKBKE |
9641 |
Q14164 |
0.63 |
|
CBX3 |
11335 |
Q13185 |
0.63 |
|
CHMP4A |
29082 |
Q9BY43 |
0.63 |
|
CHRAC1 |
54108 |
Q9NRG0 |
0.63 |
|
OTUB1 |
55611 |
Q96FW1 |
0.63 |
|
ATG10 |
83734 |
Q9H0Y0 |
0.63 |
|
SMYD1 |
150572 |
Q8NB12 |
0.76 |