Gene Symbol | CYP26A1 |
Entrez ID | 1592 |
Uniprot ID | O43174 |
Description | cytochrome P450 family 26 subfamily A member 1 |
Chromosomal Location | chr10: 93,073,475-93,077,890 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006766 |
vitamin metabolic process |
The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems. |
TAS |
BP |
GO:0006805 |
xenobiotic metabolic process |
The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide. |
IDA |
BP |
GO:0034653 |
retinoic acid catabolic process |
The chemical reactions and pathways resulting in the breakdown of retinoic acid, one of the three components that makes up vitamin A. |
IDA |
BP |
GO:0042573 |
retinoic acid metabolic process |
The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A. |
IDA |
BP |
GO:0048387 |
negative regulation of retinoic acid receptor signaling pathway |
Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity. |
TAS |
BP |
GO:0055114 |
oxidation-reduction process |
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
IEA |
CC |
GO:0005789 |
endoplasmic reticulum membrane |
The lipid bilayer surrounding the endoplasmic reticulum. |
TAS |
CC |
GO:0031090 |
organelle membrane |
A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. |
IEA |
MF |
GO:0001972 |
retinoic acid binding |
Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. |
IDA |
MF |
GO:0005506 |
iron ion binding |
Interacting selectively and non-covalently with iron (Fe) ions. |
IEA |
MF |
GO:0008401 |
retinoic acid 4-hydroxylase activity |
Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid. |
IDA|TAS |
MF |
GO:0016709 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. |
IDA |
MF |
GO:0019825 |
oxygen binding |
Interacting selectively and non-covalently with oxygen (O2). |
TAS |
MF |
GO:0020037 |
heme binding |
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. |
NAS |
Domain ID | Description |
---|---|
IPR001128 |
Cytochrome P450 |
IPR002403 |
Cytochrome P450, E-class, group IV |
IPR017972 |
Cytochrome P450, conserved site |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00830 |
Retinol metabolism |
KEGG |
hsa01100 |
Metabolic pathways |
KEGG |
WP299 |
Nuclear Receptors in Lipid Metabolism and Toxicity |
WikiPathways |
WP236 |
Adipogenesis |
WikiPathways |
WP716 |
Vitamin A and Carotenoid Metabolism |
WikiPathways |
WP702 |
Metapathway biotransformation |
WikiPathways |
WP43 |
Oxidation by Cytochrome P450 |
WikiPathways |
h_nuclearRsPathway |
Nuclear Receptors in Lipid Metabolism and Toxicity |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0001418 |
Adenocarcinoma |
C0004763 |
Barrett Esophagus |
C0009375 |
Colonic Neoplasms |
C0014175 |
Endometriosis |
C0014859 |
Esophageal Neoplasms |
C0032580 |
Adenomatous Polyposis Coli |
Pubmed ID | Author | Year | Title |
---|---|---|---|
18765015 |
Qiao et al. |
2008 |
Microarray evaluation of endometrial receptivity in Chinese women with polycystic ovary syndrome |