| Gene Symbol | SRPRB |
| Entrez ID | 58477 |
| Uniprot ID | Q9Y5M8 |
| Description | SRP receptor beta subunit |
| Chromosomal Location | chr3: 133,784,033-133,825,772 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006614 |
SRP-dependent cotranslational protein targeting to membrane |
The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. |
IBA |
|
BP |
GO:0007264 |
small GTPase mediated signal transduction |
Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. |
IEA |
|
BP |
GO:0036498 |
IRE1-mediated unfolded protein response |
A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB. |
TAS |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
|
CC |
GO:0005785 |
signal recognition particle receptor complex |
A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex. |
IBA |
|
CC |
GO:0005789 |
endoplasmic reticulum membrane |
The lipid bilayer surrounding the endoplasmic reticulum. |
TAS |
|
CC |
GO:0005881 |
cytoplasmic microtubule |
Any microtubule in the cytoplasm of a cell. |
IDA |
|
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
|
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IEA |
|
MF |
GO:0005047 |
signal recognition particle binding |
Interacting selectively and non-covalently with the signal recognition particle. |
IBA |
|
MF |
GO:0005525 |
GTP binding |
Interacting selectively and non-covalently with GTP, guanosine triphosphate. |
IEA |
| Domain ID | Description |
|---|---|
|
IPR019009 |
Signal recognition particle receptor, beta subunit |
|
IPR024156 |
Small GTPase superfamily, ARF type |
|
IPR027417 |
P-loop containing nucleoside triphosphate hydrolase |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa03060 |
Protein export |
KEGG |
| Tissue | Cell Type |
|---|---|
|
lymph node |
non-germinal center cells |
|
pancreas |
exocrine glandular cells |
|
skeletal muscle |
myocytes |
|
smooth muscle |
smooth muscle cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
ACAA1 |
30 |
P09110 |
0.49 |
|
TAGLN |
6876 |
Q01995 |
0.49 |
|
UBE2L3 |
7332 |
P68036 |
0.49 |
|
VDAC3 |
7419 |
Q9Y277 |
0.49 |
|
HRSP12 |
10247 |
P52758 |
0.49 |
|
UBE4B |
10277 |
O95155 |
0.49 |
|
TOMM40 |
10452 |
O96008 |
0.49 |
|
TARDBP |
23435 |
Q13148 |
0.49 |
|
TMBIM1 |
64114 |
Q969X1 |
0.49 |
|
TMEM65 |
157378 |
Q6PI78 |
0.49 |
|
TMED4 |
222068 |
Q7Z7H5 |
0.49 |
|
TMED2 |
10959 |
Q15363 |
0.56 |
|
ARF5 |
381 |
P84085 |
0.63 |
|
ATP12A |
479 |
P54707 |
0.63 |
|
ATP2A3 |
489 |
Q93084 |
0.63 |
|
ATP2B2 |
491 |
Q01814 |
0.63 |
|
BNIP1 |
662 |
Q12981 |
0.63 |
|
AP3S1 |
1176 |
Q92572 |
0.63 |
|
CYP51A1 |
1595 |
Q16850 |
0.63 |
|
EPHX1 |
2052 |
P07099 |
0.63 |
|
FDFT1 |
2222 |
P37268 |
0.63 |
|
HMGCR |
3156 |
P04035 |
0.63 |
|
HMOX1 |
3162 |
P09601 |
0.63 |
|
RAB8A |
4218 |
P61006 |
0.63 |
|
CTAGE5 |
4253 |
O15320 |
0.63 |
|
PDE3B |
5140 |
Q13370 |
0.63 |
|
POR |
5447 |
P16435 |
0.63 |
|
RAB6A |
5870 |
P20340 |
0.63 |
|
RAB13 |
5872 |
P51153 |
0.63 |
|
SMPD2 |
6610 |
O60906 |
0.63 |
|
STX5 |
6811 |
Q13190 |
0.63 |
|
TTC1 |
7265 |
Q99614 |
0.63 |
|
UBE3A |
7337 |
Q05086 |
0.63 |
|
VRK2 |
7444 |
Q86Y07 |
0.63 |
|
PLAA |
9373 |
Q9Y263 |
0.63 |
|
STX8 |
9482 |
Q9UNK0 |
0.63 |
|
MAGED1 |
9500 |
Q9Y5V3 |
0.63 |
|
MAD2L2 |
10459 |
Q9UI95 |
0.63 |
|
RAB18 |
22931 |
Q9NP72 |
0.63 |
|
TRIM32 |
22954 |
Q13049 |
0.63 |
|
CTDNEP1 |
23399 |
O95476 |
0.63 |
|
LEMD3 |
23592 |
Q9Y2U8 |
0.63 |
|
RNF167 |
26001 |
Q9H6Y7 |
0.63 |
|
TMX2 |
51075 |
Q9Y320 |
0.63 |
|
RDH11 |
51109 |
Q8TC12 |
0.63 |
|
SAR1B |
51128 |
Q9Y6B6 |
0.63 |
|
CD320 |
51293 |
Q9NPF0 |
0.63 |
|
THEM6 |
51337 |
Q8WUY1 |
0.63 |
|
DHRS7 |
51635 |
Q9Y394 |
0.63 |
|
STX18 |
53407 |
Q9P2W9 |
0.63 |
|
RMND1 |
55005 |
Q9NWS8 |
0.63 |
|
ARL8B |
55207 |
Q9NVJ2 |
0.63 |
|
MARC1 |
64757 |
Q5VT66 |
0.63 |
|
DDRGK1 |
65992 |
Q96HY6 |
0.63 |
|
DCAKD |
79877 |
Q8WVC6 |
0.63 |
|
GHDC |
84514 |
Q8N2G8 |
0.63 |
|
LRP11 |
84918 |
Q86VZ4 |
0.63 |
|
TMEM259 |
91304 |
Q4ZIN3 |
0.63 |
|
PDZD8 |
118987 |
Q8NEN9 |
0.63 |
|
EMB |
133418 |
Q6PCB8 |
0.63 |
|
ARL5B |
221079 |
Q96KC2 |
0.63 |
|
MIA3 |
375056 |
Q5JRA6 |
0.63 |
|
C6orf120 |
387263 |
Q7Z4R8 |
0.63 |
|
CUEDC1 |
404093 |
Q9NWM3 |
0.63 |
|
UPK3BL |
100134938 |
B0FP48 |
0.63 |
|
UBL4A |
8266 |
P11441 |
0.73 |
|
CDK5RAP3 |
80279 |
Q96JB5 |
0.82 |
|
SRPRA |
6734 |
P08240 |
0.89 |
|
LMNA |
4000 |
P02545 |
0.49 |
|
PFN1 |
5216 |
P07737 |
0.49 |
|
PIN4 |
5303 |
Q9Y237 |
0.49 |
|
RBMS1 |
5937 |
P29558 |
0.49 |
|
RFX5 |
5993 |
P48382 |
0.49 |
|
RPL38 |
6169 |
P63173 |
0.49 |
|
RRBP1 |
6238 |
Q9P2E9 |
0.49 |
|
S100A10 |
6281 |
P60903 |
0.49 |
|
SNRPC |
6631 |
P09234 |
0.49 |
|
SPR |
6697 |
P35270 |
0.49 |
|
SF1 |
7536 |
Q15637 |
0.49 |
|
SNX3 |
8724 |
O60493 |
0.49 |
|
SCO2 |
9997 |
O43819 |
0.49 |
|
SCAMP3 |
10067 |
O14828 |
0.49 |
|
PQBP1 |
10084 |
O60828 |
0.49 |
|
PPIF |
10105 |
P30405 |
0.49 |
|
MRPS31 |
10240 |
Q92665 |
0.49 |
|
SF3B4 |
10262 |
Q15427 |
0.49 |
|
TCTN3 |
26123 |
Q6NUS6 |
0.49 |
|
MRPS28 |
28957 |
Q9Y2Q9 |
0.49 |
|
SBDS |
51119 |
Q9Y3A5 |
0.49 |
|
TMEM216 |
51259 |
Q9P0N5 |
0.49 |
|
SUGP1 |
57794 |
Q8IWZ8 |
0.49 |
|
MRPL14 |
64928 |
Q6P1L8 |
0.49 |
|
NABP2 |
79035 |
Q9BQ15 |
0.49 |
|
TCTN2 |
79867 |
Q96GX1 |
0.49 |
|
SARNP |
84324 |
P82979 |
0.49 |
|
MRRF |
92399 |
Q96E11 |
0.49 |
|
RPS10P5 |
93144 |
Q9NQ39 |
0.49 |
|
EVC2 |
132884 |
Q86UK5 |
0.49 |
|
ADRB2 |
154 |
P07550 |
0.63 |
|
AMFR |
267 |
Q9UKV5 |
0.63 |
|
ARF6 |
382 |
P62330 |
0.63 |
|
CA9 |
768 |
Q16790 |
0.63 |
|
EGFR |
1956 |
P00533 |
0.63 |
|
ELAVL1 |
1994 |
Q15717 |
0.63 |
|
ILK |
3611 |
Q13418 |
0.63 |
|
EIF6 |
3692 |
P56537 |
0.63 |
|
JUN |
3725 |
P05412 |
0.63 |
|
MAGEA6 |
4105 |
P43360 |
0.63 |
|
MDM2 |
4193 |
Q00987 |
0.63 |
|
NFKBIB |
4793 |
Q15653 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
NUP98 |
4928 |
P52948 |
0.63 |
|
PCK1 |
5105 |
P35558 |
0.63 |
|
STAU1 |
6780 |
O95793 |
0.63 |
|
VHL |
7428 |
P40337 |
0.63 |
|
CUL3 |
8452 |
Q13618 |
0.63 |
|
TNFRSF14 |
8764 |
Q92956 |
0.63 |
|
PHLDA3 |
23612 |
Q9Y5J5 |
0.63 |
|
FTSJ1 |
24140 |
Q9UET6 |
0.63 |
|
FBXO6 |
26270 |
Q9NRD1 |
0.63 |
|
STYXL1 |
51657 |
Q9Y6J8 |
0.63 |
|
BRF2 |
55290 |
Q9HAW0 |
0.63 |
|
OTUB1 |
55611 |
Q96FW1 |
0.63 |
|
CCDC8 |
83987 |
Q9H0W5 |
0.63 |
|
GSTK1 |
373156 |
Q9Y2Q3 |
0.63 |
|
RCHY1 |
25898 |
Q96PM5 |
0.65 |
|
KATNA1 |
11104 |
O75449 |
0.72 |
|
ERLIN2 |
11160 |
O94905 |
0.72 |
|
PPP6R1 |
22870 |
Q9UPN7 |
0.72 |
|
NCSTN |
23385 |
Q92542 |
0.72 |
|
ATL3 |
25923 |
Q6DD88 |
0.72 |
|
TMEM63B |
55362 |
Q5T3F8 |
0.72 |
|
FAM46A |
55603 |
Q96IP4 |
0.72 |
|
TUBA1C |
84790 |
Q9BQE3 |
0.72 |
|
CASP4 |
837 |
P49662 |
0.76 |
|
NDN |
4692 |
Q99608 |
0.76 |
|
UQCRC1 |
7384 |
P31930 |
0.76 |
|
TSC22D1 |
8848 |
Q15714 |
0.76 |
|
USP14 |
9097 |
P54578 |
0.76 |
|
USP19 |
10869 |
O94966 |
0.76 |
|
PTP4A3 |
11156 |
O75365 |
0.76 |
|
USP50 |
373509 |
Q70EL3 |
0.76 |