| Gene Symbol | LSM2 |
| Entrez ID | 57819 |
| Uniprot ID | Q9Y333 |
| Description | LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated |
| Chromosomal Location | chr6: 31,797,396-31,806,984 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0000398 |
mRNA splicing, via spliceosome |
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
IBA|IC|TAS |
|
BP |
GO:0043928 |
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay |
The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail. |
TAS |
|
CC |
GO:0000932 |
cytoplasmic mRNA processing body |
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci. |
IBA |
|
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
TAS |
|
CC |
GO:0005688 |
U6 snRNP |
A ribonucleoprotein complex that contains small nuclear RNA U6. |
IBA |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
|
CC |
GO:0046540 |
U4/U6 x U5 tri-snRNP complex |
A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins. |
IBA |
|
CC |
GO:0071011 |
precatalytic spliceosome |
A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs. |
IBA |
|
CC |
GO:0071013 |
catalytic step 2 spliceosome |
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. |
IDA |
|
CC |
GO:1990726 |
Lsm1-7-Pat1 complex |
A conserved protein complex that plays an important role in coupling deadenylation and decapping in the 5'-to-3' mRNA decay pathway. An example is found in S. cerevisiae. |
IBA |
|
MF |
GO:0003723 |
RNA binding |
Interacting selectively and non-covalently with an RNA molecule or a portion thereof. |
IBA |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0017070 |
U6 snRNA binding |
Interacting selectively and non-covalently with the U6 small nuclear RNA (U6 snRNA). |
NAS |
|
MF |
GO:0017160 |
Ral GTPase binding |
Interacting selectively and non-covalently with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases. |
IPI |
|
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
| Domain ID | Description |
|---|---|
|
IPR001163 |
LSM domain, eukaryotic/archaea-type |
|
IPR010920 |
LSM domain |
|
IPR016654 |
U6 snRNA-associated Sm-like protein LSm2 |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa03018 |
RNA degradation |
KEGG |
|
hsa03040 |
Spliceosome |
KEGG |
|
WP411 |
mRNA Processing |
WikiPathways |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
bronchus |
respiratory epithelial cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
Purkinje cells |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
kidney |
cells in glomeruli |
|
kidney |
cells in tubules |
|
lung |
pneumocytes |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
ovary |
follicle cells |
|
pancreas |
exocrine glandular cells |
|
parathyroid gland |
glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skin |
melanocytes |
|
small intestine |
glandular cells |
|
soft tissue |
fibroblasts |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
|
25393639 |
Ambekar et al. |
2014 |
Proteomics of follicular fluid from women with polycystic ovary syndrome suggests molecular defects in follicular development |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
DHX38 |
9785 |
Q92620 |
0.49 |
|
PYROXD1 |
79912 |
Q8WU10 |
0.49 |
|
TRIM56 |
81844 |
Q9BRZ2 |
0.49 |
|
NAA38 |
84316 |
Q9BRA0 |
0.49 |
|
SNRPD1 |
6632 |
P62314 |
0.56 |
|
RBM8A |
9939 |
Q9Y5S9 |
0.59 |
|
PRCC |
5546 |
Q92733 |
0.63 |
|
RNH1 |
6050 |
P13489 |
0.63 |
|
RSRC1 |
51319 |
Q96IZ7 |
0.63 |
|
RAB1B |
81876 |
Q9H0U4 |
0.63 |
|
LNX1 |
84708 |
Q8TBB1 |
0.63 |
|
GBP7 |
388646 |
Q8N8V2 |
0.63 |
|
RNU4ATAC |
100151683 |
N/A |
0.63 |
|
RNU6ATAC |
100151684 |
N/A |
0.63 |
|
CLNS1A |
1207 |
P54105 |
0.73 |
|
DNAJA1 |
3301 |
P31689 |
0.74 |
|
LSM8 |
51691 |
O95777 |
0.74 |
|
SNRPD2 |
6633 |
P62316 |
0.80 |
|
SNRPE |
6635 |
P62304 |
0.80 |
|
SMN1; SMN2 |
6606 |
Q16637 |
0.85 |
|
LSM1 |
27257 |
O15116 |
0.86 |
|
DKC1 |
1736 |
O60832 |
0.49 |
|
ILF3 |
3609 |
Q12906 |
0.49 |
|
KIF5B |
3799 |
P33176 |
0.49 |
|
PKN2 |
5586 |
Q16513 |
0.49 |
|
SNRPA1 |
6627 |
P09661 |
0.49 |
|
SNX1 |
6642 |
Q13596 |
0.49 |
|
KDM5C |
8242 |
P41229 |
0.49 |
|
DHX16 |
8449 |
O60231 |
0.49 |
|
CWC27 |
10283 |
Q6UX04 |
0.49 |
|
CORO1B |
57175 |
Q9BR76 |
0.49 |
|
ZMAT2 |
153527 |
Q96NC0 |
0.49 |
|
DDB1 |
100290337 |
Q16531 |
0.49 |
|
SNRPD3 |
6634 |
P62318 |
0.56 |
|
BUD31 |
8896 |
P41223 |
0.56 |
|
AES |
166 |
Q08117 |
0.63 |
|
CRMP1 |
1400 |
Q14194 |
0.63 |
|
EMD |
2010 |
P50402 |
0.63 |
|
GBP2 |
2634 |
P32456 |
0.63 |
|
KRT13 |
3860 |
P13646 |
0.63 |
|
MAGEA6 |
4105 |
P43360 |
0.63 |
|
MEOX2 |
4223 |
P50222 |
0.63 |
|
NME2 |
4831 |
P22392 |
0.63 |
|
EXOSC10 |
5394 |
Q01780 |
0.63 |
|
RALA |
5898 |
P11233 |
0.63 |
|
REL |
5966 |
Q04864 |
0.63 |
|
SUMO2 |
6613 |
P61956 |
0.63 |
|
SNRPB |
6628 |
P14678 |
0.63 |
|
SOX2 |
6657 |
P48431 |
0.63 |
|
ZBTB16 |
7704 |
Q05516 |
0.63 |
|
PTBP3 |
9991 |
O95758 |
0.63 |
|
SF3B2 |
10992 |
Q13435 |
0.63 |
|
C14orf1 |
11161 |
Q9UKR5 |
0.63 |
|
GABARAP |
11337 |
O95166 |
0.63 |
|
GABARAPL1 |
23710 |
Q9H0R8 |
0.63 |
|
BANP |
54971 |
Q8N9N5 |
0.63 |
|
TRIM54 |
57159 |
Q9BYV2 |
0.63 |
|
LSM5 |
23658 |
Q9Y4Y9 |
0.72 |
|
MEPCE |
56257 |
Q7L2J0 |
0.72 |
|
ZNF408 |
79797 |
Q9H9D4 |
0.74 |
|
USP4 |
7375 |
Q13107 |
0.76 |
|
SART3 |
9733 |
Q15020 |
0.76 |
|
USP15 |
9958 |
Q9Y4E8 |
0.76 |
|
DDX20 |
11218 |
Q9UHI6 |
0.78 |
|
PRPF4 |
9128 |
O43172 |
0.83 |
|
LSM6 |
11157 |
P62312 |
0.85 |
|
LSM7 |
51690 |
Q9UK45 |
0.85 |
|
LSM4 |
25804 |
Q9Y4Z0 |
0.92 |
|
LSM3 |
27258 |
P62310 |
0.97 |