Gene Symbol | CYP2E1 |
Entrez ID | 1571 |
Uniprot ID | P05181 |
Description | cytochrome P450 family 2 subfamily E member 1 |
Chromosomal Location | chr10: 133,520,406-133,561,220 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006641 |
triglyceride metabolic process |
The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins. |
IEA |
BP |
GO:0006805 |
xenobiotic metabolic process |
The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide. |
TAS |
BP |
GO:0008202 |
steroid metabolic process |
The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. |
IMP |
BP |
GO:0010193 |
response to ozone |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus. |
IEA |
BP |
GO:0010243 |
response to organonitrogen compound |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. |
IEA |
BP |
GO:0016098 |
monoterpenoid metabolic process |
The chemical reactions and pathways involving monoterpenoid compounds, terpenoids having a C10 skeleton. |
IDA |
BP |
GO:0017144 |
drug metabolic process |
The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice. |
IDA|IMP|TAS |
BP |
GO:0018885 |
carbon tetrachloride metabolic process |
The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants. |
TAS |
BP |
GO:0018910 |
benzene metabolic process |
The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation. |
TAS |
BP |
GO:0019373 |
epoxygenase P450 pathway |
The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids. |
IBA |
BP |
GO:0042197 |
halogenated hydrocarbon metabolic process |
The chemical reactions and pathways involving halogenated hydrocarbons, any hydrocarbon with one or more halogen atoms attached to it. Halogens include fluorine, chlorine, bromine and iodine. |
TAS |
BP |
GO:0042493 |
response to drug |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. |
IEA |
BP |
GO:0045471 |
response to ethanol |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. |
IEA |
BP |
GO:0046483 |
heterocycle metabolic process |
The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). |
IDA |
BP |
GO:0055114 |
oxidation-reduction process |
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
IDA |
CC |
GO:0000139 |
Golgi membrane |
The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
IEA |
CC |
GO:0005739 |
mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
IEA |
CC |
GO:0005789 |
endoplasmic reticulum membrane |
The lipid bilayer surrounding the endoplasmic reticulum. |
TAS |
CC |
GO:0031227 |
intrinsic component of endoplasmic reticulum membrane |
The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. |
IEA |
MF |
GO:0004497 |
monooxygenase activity |
Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. |
IDA |
MF |
GO:0005506 |
iron ion binding |
Interacting selectively and non-covalently with iron (Fe) ions. |
IEA |
MF |
GO:0008392 |
arachidonic acid epoxygenase activity |
Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid. |
IBA |
MF |
GO:0008395 |
steroid hydroxylase activity |
Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. |
IBA |
MF |
GO:0016491 |
oxidoreductase activity |
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
IDA |
MF |
GO:0016709 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. |
TAS |
MF |
GO:0016712 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. |
IEA |
MF |
GO:0019825 |
oxygen binding |
Interacting selectively and non-covalently with oxygen (O2). |
TAS |
MF |
GO:0019899 |
enzyme binding |
Interacting selectively and non-covalently with any enzyme. |
IPI |
MF |
GO:0020037 |
heme binding |
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. |
IDA |
Domain ID | Description |
---|---|
IPR001128 |
Cytochrome P450 |
IPR002401 |
Cytochrome P450, E-class, group I |
IPR008070 |
Cytochrome P450, E-class, group I, CYP2E-like |
IPR017972 |
Cytochrome P450, conserved site |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00140 |
Steroid hormone biosynthesis |
KEGG |
hsa00590 |
Arachidonic acid metabolism |
KEGG |
hsa00591 |
Linoleic acid metabolism |
KEGG |
hsa00980 |
Metabolism of xenobiotics by cytochrome P450 |
KEGG |
hsa00982 |
Drug metabolism - cytochrome P450 |
KEGG |
hsa01100 |
Metabolic pathways |
KEGG |
hsa04932 |
Non-alcoholic fatty liver disease (NAFLD) |
KEGG |
hsa05204 |
Chemical carcinogenesis |
KEGG |
WP3891 |
Benzene metabolism |
WikiPathways |
WP1589 |
Folate-Alcohol and Cancer Pathway |
WikiPathways |
WP299 |
Nuclear Receptors in Lipid Metabolism and Toxicity |
WikiPathways |
WP465 |
Tryptophan metabolism |
WikiPathways |
WP3627 |
Gut-Liver Indole Metabolism |
WikiPathways |
WP716 |
Vitamin A and Carotenoid Metabolism |
WikiPathways |
WP702 |
Metapathway biotransformation |
WikiPathways |
WP2816 |
Felbamate Metabolism |
WikiPathways |
WP691 |
Tamoxifen metabolism |
WikiPathways |
WP43 |
Oxidation by Cytochrome P450 |
WikiPathways |
WP206 |
Fatty Acid Omega Oxidation |
WikiPathways |
h_AcetaminophenPathway |
Mechanism of Acetaminophen Activity and Toxicity |
BioCarta |
h_nuclearRsPathway |
Nuclear Receptors in Lipid Metabolism and Toxicity |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0001418 |
Adenocarcinoma |
C0001973 |
Alcoholic Intoxication, Chronic |
C0007131 |
Non-Small Cell Lung Carcinoma |
C0011609 |
Drug Eruptions |
C0015695 |
Fatty Liver |
C0018800 |
Cardiomegaly |
C0023891 |
Liver Cirrhosis, Alcoholic |
C0023903 |
Liver Neoplasms |
C0023904 |
Liver Neoplasms, Experimental |
C0024121 |
Lung Neoplasms |
C0024305 |
Lymphoma, Non-Hodgkin |
C0027540 |
Necrosis |
C0027626 |
Neoplasm Invasiveness |
C0028754 |
Obesity |
C0030567 |
Parkinson Disease |
C0033578 |
Prostatic Neoplasms |
C0041755 |
Adverse Reaction To Drug |
C0860207 |
Drug-Induced Liver Injury |
C1449861 |
Micronuclei, Chromosome-Defective |
C2239176 |
Liver Carcinoma |
Tissue | Cell Type |
---|---|
liver |
hepatocytes |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
GATM |
2628 |
P50440 |
0.63 |
PTN |
5764 |
P21246 |
0.63 |
RPL13A |
23521 |
P40429 |
0.63 |
POR |
5447 |
P16435 |
0.85 |
AMFR |
267 |
Q9UKV5 |
0.52 |
STUB1 |
10273 |
Q9UNE7 |
0.52 |
PRRT2 |
112476 |
Q7Z6L0 |
0.52 |
CYB5A |
1528 |
P00167 |
0.56 |
CLU |
1191 |
P10909 |
0.63 |
ECHS1 |
1892 |
P30084 |
0.63 |
MAFG |
4097 |
O15525 |
0.63 |
NMI |
9111 |
Q13287 |
0.63 |
LAMC3 |
10319 |
Q9Y6N6 |
0.63 |
ABCA5 |
23461 |
Q8WWZ7 |
0.63 |
AGXT2 |
64902 |
Q9BYV1 |
0.63 |
FANCG |
2189 |
O15287 |
0.84 |