Protein Description

Gene Symbol CYP2E1
Entrez ID 1571
Uniprot ID P05181
Description cytochrome P450 family 2 subfamily E member 1
Chromosomal Location chr10: 133,520,406-133,561,220
Ontology GO ID GO Term Definition Evidence

BP

GO:0006641

triglyceride metabolic process

The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.

IEA

BP

GO:0006805

xenobiotic metabolic process

The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.

TAS

BP

GO:0008202

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

IMP

BP

GO:0010193

response to ozone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus.

IEA

BP

GO:0010243

response to organonitrogen compound

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.

IEA

BP

GO:0016098

monoterpenoid metabolic process

The chemical reactions and pathways involving monoterpenoid compounds, terpenoids having a C10 skeleton.

IDA

BP

GO:0017144

drug metabolic process

The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice.

IDA|IMP|TAS

BP

GO:0018885

carbon tetrachloride metabolic process

The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants.

TAS

BP

GO:0018910

benzene metabolic process

The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation.

TAS

BP

GO:0019373

epoxygenase P450 pathway

The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids.

IBA

BP

GO:0042197

halogenated hydrocarbon metabolic process

The chemical reactions and pathways involving halogenated hydrocarbons, any hydrocarbon with one or more halogen atoms attached to it. Halogens include fluorine, chlorine, bromine and iodine.

TAS

BP

GO:0042493

response to drug

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.

IEA

BP

GO:0045471

response to ethanol

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.

IEA

BP

GO:0046483

heterocycle metabolic process

The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).

IDA

BP

GO:0055114

oxidation-reduction process

A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.

IDA

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

IEA

CC

GO:0005739

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

IEA

CC

GO:0005789

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

TAS

CC

GO:0031227

intrinsic component of endoplasmic reticulum membrane

The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.

IEA

MF

GO:0004497

monooxygenase activity

Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.

IDA

MF

GO:0005506

iron ion binding

Interacting selectively and non-covalently with iron (Fe) ions.

IEA

MF

GO:0008392

arachidonic acid epoxygenase activity

Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid.

IBA

MF

GO:0008395

steroid hydroxylase activity

Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.

IBA

MF

GO:0016491

oxidoreductase activity

Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

IDA

MF

GO:0016709

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor.

TAS

MF

GO:0016712

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor.

IEA

MF

GO:0019825

oxygen binding

Interacting selectively and non-covalently with oxygen (O2).

TAS

MF

GO:0019899

enzyme binding

Interacting selectively and non-covalently with any enzyme.

IPI

MF

GO:0020037

heme binding

Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.

IDA

Domain ID Description

IPR001128

Cytochrome P450

IPR002401

Cytochrome P450, E-class, group I

IPR008070

Cytochrome P450, E-class, group I, CYP2E-like

IPR017972

Cytochrome P450, conserved site

Pathway ID Pathway Term Pathway Source

hsa00140

Steroid hormone biosynthesis

KEGG

hsa00590

Arachidonic acid metabolism

KEGG

hsa00591

Linoleic acid metabolism

KEGG

hsa00980

Metabolism of xenobiotics by cytochrome P450

KEGG

hsa00982

Drug metabolism - cytochrome P450

KEGG

hsa01100

Metabolic pathways

KEGG

hsa04932

Non-alcoholic fatty liver disease (NAFLD)

KEGG

hsa05204

Chemical carcinogenesis

KEGG

WP3891

Benzene metabolism

WikiPathways

WP1589

Folate-Alcohol and Cancer Pathway

WikiPathways

WP299

Nuclear Receptors in Lipid Metabolism and Toxicity

WikiPathways

WP465

Tryptophan metabolism

WikiPathways

WP3627

Gut-Liver Indole Metabolism

WikiPathways

WP716

Vitamin A and Carotenoid Metabolism

WikiPathways

WP702

Metapathway biotransformation

WikiPathways

WP2816

Felbamate Metabolism

WikiPathways

WP691

Tamoxifen metabolism

WikiPathways

WP43

Oxidation by Cytochrome P450

WikiPathways

WP206

Fatty Acid Omega Oxidation

WikiPathways

h_AcetaminophenPathway

Mechanism of Acetaminophen Activity and Toxicity

BioCarta

h_nuclearRsPathway

Nuclear Receptors in Lipid Metabolism and Toxicity

BioCarta

UMLS CUI UMLS Term

C0001418

Adenocarcinoma

C0001973

Alcoholic Intoxication, Chronic

C0007131

Non-Small Cell Lung Carcinoma

C0011609

Drug Eruptions

C0015695

Fatty Liver

C0018800

Cardiomegaly

C0023891

Liver Cirrhosis, Alcoholic

C0023903

Liver Neoplasms

C0023904

Liver Neoplasms, Experimental

C0024121

Lung Neoplasms

C0024305

Lymphoma, Non-Hodgkin

C0027540

Necrosis

C0027626

Neoplasm Invasiveness

C0028754

Obesity

C0030567

Parkinson Disease

C0033578

Prostatic Neoplasms

C0041755

Adverse Reaction To Drug

C0860207

Drug-Induced Liver Injury

C1449861

Micronuclei, Chromosome-Defective

C2239176

Liver Carcinoma

Tissue Cell Type

liver

hepatocytes

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

GATM

2628

P50440

0.63

PTN

5764

P21246

0.63

RPL13A

23521

P40429

0.63

POR

5447

P16435

0.85

AMFR

267

Q9UKV5

0.52

STUB1

10273

Q9UNE7

0.52

PRRT2

112476

Q7Z6L0

0.52

CYB5A

1528

P00167

0.56

CLU

1191

P10909

0.63

ECHS1

1892

P30084

0.63

MAFG

4097

O15525

0.63

NMI

9111

Q13287

0.63

LAMC3

10319

Q9Y6N6

0.63

ABCA5

23461

Q8WWZ7

0.63

AGXT2

64902

Q9BYV1

0.63

FANCG

2189

O15287

0.84