Protein Description

Gene Symbol RHOJ
Entrez ID 57381
Uniprot ID Q9H4E5
Description ras homolog family member J
Chromosomal Location chr14: 63,204,114-63,293,219
Ontology GO ID GO Term Definition Evidence

BP

GO:0007266

Rho protein signal transduction

A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.

IEA

BP

GO:0008360

regulation of cell shape

Any process that modulates the surface configuration of a cell.

IEA

BP

GO:0030036

actin cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.

IMP

BP

GO:0051056

regulation of small GTPase mediated signal transduction

Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.

TAS

BP

GO:0061299

retina vasculature morphogenesis in camera-type eye

The process in which the vasculature of the retina is generated and organized.

IEA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TAS

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0003924

GTPase activity

Catalysis of the reaction: GTP + H2O = GDP + phosphate.

NAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005525

GTP binding

Interacting selectively and non-covalently with GTP, guanosine triphosphate.

IEA

Domain ID Description

IPR001806

Small GTPase superfamily

IPR003578

Small GTPase superfamily, Rho type

IPR005225

Small GTP-binding protein domain

IPR027417

P-loop containing nucleoside triphosphate hydrolase

Pathway ID Pathway Term Pathway Source

WP481

Insulin Signaling

WikiPathways

WP3888

VEGFA-VEGFR2 Signaling Pathway

WikiPathways

UMLS CUI UMLS Term

C0009375

Colonic Neoplasms

C0878544

Cardiomyopathies

Tissue Cell Type

adrenal gland

glandular cells

breast

glandular cells

bronchus

respiratory epithelial cells

duodenum

glandular cells

fallopian tube

glandular cells

lymph node

germinal center cells

nasopharynx

respiratory epithelial cells

ovary

follicle cells

parathyroid gland

glandular cells

seminal vesicle

glandular cells

skin

fibroblasts

small intestine

glandular cells

soft tissue

chondrocytes

soft tissue

fibroblasts

soft tissue

adipocytes

testis

cells in seminiferous ducts

urinary bladder

urothelial cells

No databases found.

Pubmed ID Author Year Title

23824412

Piltonen et al.

2013

Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential

Gene Symbol Entrez ID Uniprot ID Score

SMAD2

4087

Q15796

0.52

SMAD4

4089

Q13485

0.52

TGFBR1

7046

P36897

0.52

CSNK1D

1453

P48730

0.63

PRKCI

5584

P41743

0.63

EIF5B

9669

O60841

0.63

USP24

23358

Q9UPU5

0.63

AARSD1

80755

Q9BTE6

0.63

FAM177A1

283635

Q8N128

0.63

CDC42

998

P60953

0.65

WAS

7454

P42768

0.80

PARD6B

84612

Q9BYG5

0.82

PAK1

5058

Q13153

0.86

ACVR1

90

Q04771

0.52

BMPR1B

658

O00238

0.52

DOCK10

55619

Q96BY6

0.52

MEOX2

4223

P50222

0.63

BLZF1

8548

Q9H2G9

0.63

BHLHE40

8553

O14503

0.63

WASL

8976

O00401

0.63

TRIP10

9322

Q15642

0.63

CDC42EP1

11135

Q00587

0.63

ADAMTSL4

54507

Q6UY14

0.63

PAK6

56924

Q9NQU5

0.63

DOCK8

81704

Q8NF50

0.63

SSX3

10214

Q99909

0.72

PAK2

5062

Q13177

0.82