Gene Symbol | RHOJ |
Entrez ID | 57381 |
Uniprot ID | Q9H4E5 |
Description | ras homolog family member J |
Chromosomal Location | chr14: 63,204,114-63,293,219 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0007266 |
Rho protein signal transduction |
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state. |
IEA |
BP |
GO:0008360 |
regulation of cell shape |
Any process that modulates the surface configuration of a cell. |
IEA |
BP |
GO:0030036 |
actin cytoskeleton organization |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
IMP |
BP |
GO:0051056 |
regulation of small GTPase mediated signal transduction |
Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction. |
TAS |
BP |
GO:0061299 |
retina vasculature morphogenesis in camera-type eye |
The process in which the vasculature of the retina is generated and organized. |
IEA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
TAS |
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
MF |
GO:0003924 |
GTPase activity |
Catalysis of the reaction: GTP + H2O = GDP + phosphate. |
NAS |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0005525 |
GTP binding |
Interacting selectively and non-covalently with GTP, guanosine triphosphate. |
IEA |
Domain ID | Description |
---|---|
IPR001806 |
Small GTPase superfamily |
IPR003578 |
Small GTPase superfamily, Rho type |
IPR005225 |
Small GTP-binding protein domain |
IPR027417 |
P-loop containing nucleoside triphosphate hydrolase |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
WP481 |
Insulin Signaling |
WikiPathways |
WP3888 |
VEGFA-VEGFR2 Signaling Pathway |
WikiPathways |
UMLS CUI | UMLS Term |
---|---|
C0009375 |
Colonic Neoplasms |
C0878544 |
Cardiomyopathies |
Tissue | Cell Type |
---|---|
adrenal gland |
glandular cells |
breast |
glandular cells |
bronchus |
respiratory epithelial cells |
duodenum |
glandular cells |
fallopian tube |
glandular cells |
lymph node |
germinal center cells |
nasopharynx |
respiratory epithelial cells |
ovary |
follicle cells |
parathyroid gland |
glandular cells |
seminal vesicle |
glandular cells |
skin |
fibroblasts |
small intestine |
glandular cells |
soft tissue |
chondrocytes |
soft tissue |
fibroblasts |
soft tissue |
adipocytes |
testis |
cells in seminiferous ducts |
urinary bladder |
urothelial cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
23824412 |
Piltonen et al. |
2013 |
Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
SMAD2 |
4087 |
Q15796 |
0.52 |
SMAD4 |
4089 |
Q13485 |
0.52 |
TGFBR1 |
7046 |
P36897 |
0.52 |
CSNK1D |
1453 |
P48730 |
0.63 |
PRKCI |
5584 |
P41743 |
0.63 |
EIF5B |
9669 |
O60841 |
0.63 |
USP24 |
23358 |
Q9UPU5 |
0.63 |
AARSD1 |
80755 |
Q9BTE6 |
0.63 |
FAM177A1 |
283635 |
Q8N128 |
0.63 |
CDC42 |
998 |
P60953 |
0.65 |
WAS |
7454 |
P42768 |
0.80 |
PARD6B |
84612 |
Q9BYG5 |
0.82 |
PAK1 |
5058 |
Q13153 |
0.86 |
ACVR1 |
90 |
Q04771 |
0.52 |
BMPR1B |
658 |
O00238 |
0.52 |
DOCK10 |
55619 |
Q96BY6 |
0.52 |
MEOX2 |
4223 |
P50222 |
0.63 |
BLZF1 |
8548 |
Q9H2G9 |
0.63 |
BHLHE40 |
8553 |
O14503 |
0.63 |
WASL |
8976 |
O00401 |
0.63 |
TRIP10 |
9322 |
Q15642 |
0.63 |
CDC42EP1 |
11135 |
Q00587 |
0.63 |
ADAMTSL4 |
54507 |
Q6UY14 |
0.63 |
PAK6 |
56924 |
Q9NQU5 |
0.63 |
DOCK8 |
81704 |
Q8NF50 |
0.63 |
SSX3 |
10214 |
Q99909 |
0.72 |
PAK2 |
5062 |
Q13177 |
0.82 |