Gene Symbol | MAN1C1 |
Entrez ID | 57134 |
Uniprot ID | Q9NR34 |
Description | mannosidase, alpha, class 1C, member 1 |
Chromosomal Location | chr1: 25,617,468-25,786,207 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006487 |
protein N-linked glycosylation |
A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. |
TAS |
BP |
GO:0006491 |
N-glycan processing |
The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking. |
IBA |
BP |
GO:1904381 |
Golgi apparatus mannose trimming |
Any protein alpha-1,2-demannosylation that takes place in the Golgi apparatus. |
TAS |
CC |
GO:0000139 |
Golgi membrane |
The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
TAS |
CC |
GO:0005783 |
endoplasmic reticulum |
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
IBA |
CC |
GO:0030173 |
integral component of Golgi membrane |
The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
TAS |
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
MF |
GO:0004571 |
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity |
Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide. |
TAS |
MF |
GO:0005509 |
calcium ion binding |
Interacting selectively and non-covalently with calcium ions (Ca2+). |
TAS |
Domain ID | Description |
---|---|
IPR001382 |
Glycoside hydrolase family 47 |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00510 |
N-Glycan biosynthesis |
KEGG |
hsa01100 |
Metabolic pathways |
KEGG |
hsa04141 |
Protein processing in endoplasmic reticulum |
KEGG |
h_eradPathway |
ER�associated degradation (ERAD) Pathway |
BioCarta |
h_aMANpathway |
Steps in the Glycosylation of Mammalian N-linked Oligosaccarides |
BioCarta |
Tissue | Cell Type |
---|---|
placenta |
trophoblastic cells |
testis |
Leydig cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
17148555 |
Wood et al. |
2007 |
Molecular Abnormalities in Oocytes from Women with Polycystic Ovary Syndrome Revealed by Microarray Analysis |
22904171 |
Kaur et al. |
2012 |
Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
SMAD9 |
4093 |
O15198 |
0.63 |