Protein Description

Gene Symbol MAN1C1
Entrez ID 57134
Uniprot ID Q9NR34
Description mannosidase, alpha, class 1C, member 1
Chromosomal Location chr1: 25,617,468-25,786,207
Ontology GO ID GO Term Definition Evidence

BP

GO:0006487

protein N-linked glycosylation

A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan.

TAS

BP

GO:0006491

N-glycan processing

The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking.

IBA

BP

GO:1904381

Golgi apparatus mannose trimming

Any protein alpha-1,2-demannosylation that takes place in the Golgi apparatus.

TAS

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

TAS

CC

GO:0005783

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

IBA

CC

GO:0030173

integral component of Golgi membrane

The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

TAS

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0004571

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide.

TAS

MF

GO:0005509

calcium ion binding

Interacting selectively and non-covalently with calcium ions (Ca2+).

TAS

Domain ID Description

IPR001382

Glycoside hydrolase family 47

Pathway ID Pathway Term Pathway Source

hsa00510

N-Glycan biosynthesis

KEGG

hsa01100

Metabolic pathways

KEGG

hsa04141

Protein processing in endoplasmic reticulum

KEGG

h_eradPathway

ER�associated degradation (ERAD) Pathway

BioCarta

h_aMANpathway

Steps in the Glycosylation of Mammalian N-linked Oligosaccarides

BioCarta

No diseases found.

Tissue Cell Type

placenta

trophoblastic cells

testis

Leydig cells

No databases found.

Pubmed ID Author Year Title

17148555

Wood et al.

2007

Molecular Abnormalities in Oocytes from Women with Polycystic Ovary Syndrome Revealed by Microarray Analysis

22904171

Kaur et al.

2012

Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis

Gene Symbol Entrez ID Uniprot ID Score

SMAD9

4093

O15198

0.63