BP

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IMP

BP

GO:0000188

inactivation of MAPK activity

Any process that terminates the activity of the active enzyme MAP kinase.

TAS

BP

GO:0002710

negative regulation of T cell mediated immunity

Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity.

IEA

BP

GO:0006470

protein dephosphorylation

The process of removing one or more phosphoric residues from a protein.

TAS

BP

GO:0006915

apoptotic process

A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.

TAS

BP

GO:0007179

transforming growth factor beta receptor signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IBA

BP

GO:0007275

multicellular organism development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

TAS

BP

GO:0008283

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

TAS

BP

GO:0035335

peptidyl-tyrosine dephosphorylation

The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.

IEA

BP

GO:0042127

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

IBA

BP

GO:0046330

positive regulation of JNK cascade

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.

IBA

BP

GO:0050860

negative regulation of T cell receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.

IEA

BP

GO:0050868

negative regulation of T cell activation

Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation.

IEA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IEA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IEA

MF

GO:0004725

protein tyrosine phosphatase activity

Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

IEA

MF

GO:0008138

protein tyrosine/serine/threonine phosphatase activity

Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

IEA