| Gene Symbol | CTPS1 |
| Entrez ID | 1503 |
| Uniprot ID | P17812 |
| Description | CTP synthase 1 |
| Chromosomal Location | chr1: 40,979,335-41,012,565 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006139 |
nucleobase-containing compound metabolic process |
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. |
TAS |
|
BP |
GO:0006241 |
CTP biosynthetic process |
The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. |
IDA|IMP |
|
BP |
GO:0006541 |
glutamine metabolic process |
The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. |
IEA |
|
BP |
GO:0015949 |
nucleobase-containing small molecule interconversion |
The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule. |
TAS |
|
BP |
GO:0042098 |
T cell proliferation |
The expansion of a T cell population by cell division. Follows T cell activation. |
IMP |
|
BP |
GO:0042100 |
B cell proliferation |
The expansion of a B cell population by cell division. Follows B cell activation. |
IMP |
|
BP |
GO:0042493 |
response to drug |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. |
TAS |
|
BP |
GO:0044210 |
de novo' CTP biosynthetic process |
The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components. |
IEA |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
|
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
|
MF |
GO:0003883 |
CTP synthase activity |
Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP. |
EXP|IDA|IGI|IMP |
|
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IEA |
| Domain ID | Description |
|---|---|
|
IPR004468 |
CTP synthase |
|
IPR017456 |
CTP synthase, N-terminal |
|
IPR017926 |
Glutamine amidotransferase |
|
IPR027417 |
P-loop containing nucleoside triphosphate hydrolase |
|
IPR029062 |
Class I glutamine amidotransferase-like |
|
IPR033828 |
CTP synthase GATase domain |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00240 |
Pyrimidine metabolism |
KEGG |
|
hsa01100 |
Metabolic pathways |
KEGG |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
bronchus |
respiratory epithelial cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
cells in molecular layer |
|
cerebellum |
Purkinje cells |
|
cervix, uterine |
glandular cells |
|
colon |
endothelial cells |
|
colon |
glandular cells |
|
colon |
peripheral nerve/ganglion |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
heart muscle |
myocytes |
|
kidney |
cells in tubules |
|
lung |
macrophages |
|
lung |
pneumocytes |
|
nasopharynx |
respiratory epithelial cells |
|
parathyroid gland |
glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skin |
fibroblasts |
|
small intestine |
glandular cells |
|
smooth muscle |
smooth muscle cells |
|
soft tissue |
fibroblasts |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
squamous epithelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
PRMT1 |
3276 |
Q99873 |
0.49 |
|
IMPDH2 |
3615 |
P12268 |
0.49 |
|
SNU13 |
4809 |
P55769 |
0.49 |
|
TSN |
7247 |
Q15631 |
0.49 |
|
POLR1C |
9533 |
O15160 |
0.49 |
|
SKIV2L2 |
23517 |
P42285 |
0.49 |
|
PUS7 |
54517 |
Q96PZ0 |
0.49 |
|
RBM28 |
55131 |
Q9NW13 |
0.49 |
|
CTBP2 |
1488 |
P56545 |
0.56 |
|
NMD3 |
51068 |
Q96D46 |
0.56 |
|
DFFA |
1676 |
O00273 |
0.63 |
|
PPP5C |
5536 |
P53041 |
0.63 |
|
PAPSS1 |
9061 |
O43252 |
0.63 |
|
IKBKE |
9641 |
Q14164 |
0.63 |
|
GINS3 |
64785 |
Q9BRX5 |
0.63 |
|
DCTPP1 |
79077 |
Q9H773 |
0.63 |
|
PKM |
5315 |
P14618 |
0.70 |
|
CTPS1 |
1503 |
P17812 |
0.72 |
|
RNF169 |
254225 |
Q8NCN4 |
0.07 |
|
EIF4B |
1975 |
P23588 |
0.49 |
|
ERCC2 |
2068 |
P18074 |
0.49 |
|
PLCG1 |
5335 |
P19174 |
0.49 |
|
SNX2 |
6643 |
O60749 |
0.49 |
|
TTC4 |
7268 |
O95801 |
0.49 |
|
PRMT5 |
10419 |
O14744 |
0.49 |
|
STRAP |
11171 |
Q9Y3F4 |
0.49 |
|
PDCD10 |
11235 |
Q9BUL8 |
0.49 |
|
RTFDC1 |
51507 |
Q9BY42 |
0.49 |
|
TRMT1 |
55621 |
Q9NXH9 |
0.49 |
|
WDR36 |
134430 |
Q8NI36 |
0.49 |
|
IMPDH1 |
3614 |
P20839 |
0.56 |
|
GMPS |
8833 |
P49915 |
0.56 |
|
ACO1 |
48 |
P21399 |
0.63 |
|
CDK2 |
1017 |
P24941 |
0.63 |
|
CLNS1A |
1207 |
P54105 |
0.63 |
|
CS |
1431 |
O75390 |
0.63 |
|
CSNK1E |
1454 |
P49674 |
0.63 |
|
HLA-B |
3106 |
P30480 |
0.63 |
|
HLA-C |
3107 |
P30504 |
0.63 |
|
MCM2 |
4171 |
P49736 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
PRKAB1 |
5564 |
Q9Y478 |
0.63 |
|
RAD21 |
5885 |
O60216 |
0.63 |
|
SUMO3 |
6612 |
P55854 |
0.63 |
|
AURKA |
6790 |
O14965 |
0.63 |
|
UBA1 |
7317 |
P22314 |
0.63 |
|
VCL |
7414 |
P18206 |
0.63 |
|
YWHAB |
7529 |
P31946 |
0.63 |
|
CUL5 |
8065 |
Q93034 |
0.63 |
|
BCAR3 |
8412 |
O75815 |
0.63 |
|
CUL4B |
8450 |
Q13620 |
0.63 |
|
CUL3 |
8452 |
Q13618 |
0.63 |
|
CUL2 |
8453 |
Q13617 |
0.63 |
|
CUL1 |
8454 |
Q13616 |
0.63 |
|
KIAA0101 |
9768 |
Q15004 |
0.63 |
|
PTBP3 |
9991 |
O95758 |
0.63 |
|
TUBGCP3 |
10426 |
Q96CW5 |
0.63 |
|
COPS5 |
10987 |
Q92905 |
0.63 |
|
FAM107A |
11170 |
O95990 |
0.63 |
|
GABARAP |
11337 |
O95166 |
0.63 |
|
GABARAPL2 |
11345 |
P60520 |
0.63 |
|
GABARAPL1 |
23710 |
Q9H0R8 |
0.63 |
|
FBXO6 |
26270 |
Q9NRD1 |
0.63 |
|
UBXN1 |
51035 |
Q04323 |
0.63 |
|
PINX1 |
54984 |
Q96BK5 |
0.63 |
|
OTUB1 |
55611 |
Q96FW1 |
0.63 |
|
CAND1 |
55832 |
Q86VP6 |
0.63 |
|
MAP1LC3B |
81631 |
Q9GZQ8 |
0.63 |
|
MAP1LC3A |
84557 |
Q9H492 |
0.63 |
|
YWHAZ |
7534 |
P63104 |
0.68 |
|
YWHAQ |
10971 |
P27348 |
0.68 |
|
PSMA3 |
5684 |
P25788 |
0.70 |
|
SUMO1 |
7341 |
P63165 |
0.70 |
|
ARRB2 |
409 |
P32121 |
0.72 |
|
OFD1 |
8481 |
O75665 |
0.72 |
|
SNX3 |
8724 |
O60493 |
0.72 |
|
RPGRIP1L |
23322 |
Q68CZ1 |
0.72 |
|
LCA5 |
167691 |
Q86VQ0 |
0.72 |
|
NEDD8 |
4738 |
Q15843 |
0.73 |
|
SUMO2 |
6613 |
P61956 |
0.73 |
|
UBA6 |
55236 |
A0AVT1 |
0.73 |
|
YWHAG |
7532 |
P61981 |
0.75 |
|
TRAF6 |
7189 |
Q9Y4K3 |
0.76 |
|
MYC |
4609 |
P01106 |
0.86 |