Protein Description

Gene Symbol TMEM165
Entrez ID 55858
Uniprot ID Q9HC07
Description transmembrane protein 165
Chromosomal Location chr4: 55,395,957-55,453,397
Ontology GO ID GO Term Definition Evidence

BP

GO:0006487

protein N-linked glycosylation

A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan.

IMP

BP

GO:0006874

cellular calcium ion homeostasis

Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.

IGI

BP

GO:0032472

Golgi calcium ion transport

The directed movement of calcium ions (Ca2+) into, out of or within the Golgi apparatus.

IDA

BP

GO:0035751

regulation of lysosomal lumen pH

Any process that modulates the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion.

IMP

CC

GO:0005765

lysosomal membrane

The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.

IDA

CC

GO:0005794

Golgi apparatus

A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.

IDA

CC

GO:0010008

endosome membrane

The lipid bilayer surrounding an endosome.

IDA

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

CC

GO:0031901

early endosome membrane

The lipid bilayer surrounding an early endosome.

IEA

CC

GO:0031902

late endosome membrane

The lipid bilayer surrounding a late endosome.

IEA

CC

GO:0032588

trans-Golgi network membrane

The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.

IDA

CC

GO:0043231

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

IDA

Domain ID Description

IPR001727

Gdt1 family

No pathways found.

No diseases found.

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

bronchus

respiratory epithelial cells

cerebellum

Purkinje cells

cervix, uterine

glandular cells

colon

glandular cells

duodenum

glandular cells

endometrium

glandular cells

epididymis

glandular cells

fallopian tube

glandular cells

lymph node

germinal center cells

nasopharynx

respiratory epithelial cells

pancreas

exocrine glandular cells

pancreas

islets of Langerhans

placenta

decidual cells

placenta

trophoblastic cells

prostate

glandular cells

rectum

glandular cells

seminal vesicle

glandular cells

soft tissue

chondrocytes

stomach

glandular cells

testis

Leydig cells

tonsil

germinal center cells

tonsil

squamous epithelial cells

urinary bladder

urothelial cells

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

REL

5966

Q04864

0.63

AHSP

51327

Q9NZD4

0.63

CALU

813

O43852

0.49

MTHFD1

4522

P11586

0.49

RPLP1

6176

P05386

0.49

RPS26

6231

P62854

0.49

CUL3

8452

Q13618

0.63

SLC38A1

81539

Q9H2H9

0.63

CDK1

983

P06493

0.72

CNOT2

4848

Q9NZN8

0.72

CDK2AP1

8099

O14519

0.72

SMC3

9126

Q9UQE7

0.72

GPATCH8

23131

Q9UKJ3

0.72

SMC6

79677

Q96SB8

0.72

USP43

124739

Q70EL4

0.72