| Gene Symbol | EMC3 |
| Entrez ID | 55831 |
| Uniprot ID | Q9P0I2 |
| Description | ER membrane protein complex subunit 3 |
| Chromosomal Location | chr3: 9,962,537-10,011,116 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0008150 |
biological_process |
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end. |
ND |
|
BP |
GO:0034975 |
protein folding in endoplasmic reticulum |
A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation). |
IBA |
|
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IDA |
|
CC |
GO:0072546 |
ER membrane protein complex |
A transmembrane protein complex that is involved in protein folding in the endoplasmic reticulum. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6. |
IDA |
|
MF |
GO:0003674 |
molecular_function |
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions. |
ND |
| Domain ID | Description |
|---|---|
|
IPR002809 |
Integral membrane protein EMC3/TMCO1-like |
|
IPR008568 |
ER membrane protein complex subunit 3 |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
bone marrow |
hematopoietic cells |
|
bronchus |
respiratory epithelial cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
hippocampus |
neuronal cells |
|
kidney |
cells in tubules |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
seminal vesicle |
glandular cells |
|
skin |
keratinocytes |
|
small intestine |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
thyroid gland |
glandular cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
25393639 |
Ambekar et al. |
2014 |
Proteomics of follicular fluid from women with polycystic ovary syndrome suggests molecular defects in follicular development |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
UBQLN2 |
29978 |
Q9UHD9 |
0.63 |
|
EMC9 |
51016 |
Q9Y3B6 |
0.63 |
|
EMC4 |
51234 |
Q5J8M3 |
0.63 |
|
EMC10 |
284361 |
Q5UCC4 |
0.63 |
|
EMC2 |
9694 |
Q15006 |
0.83 |
|
DCTN1 |
1639 |
Q14203 |
0.49 |
|
OFD1 |
8481 |
O75665 |
0.49 |
|
RPGRIP1L |
23322 |
Q68CZ1 |
0.49 |
|
TCTN3 |
26123 |
Q6NUS6 |
0.49 |
|
TMEM216 |
51259 |
Q9P0N5 |
0.49 |
|
TMEM237 |
65062 |
Q96Q45 |
0.49 |
|
TCTN1 |
79600 |
Q2MV58 |
0.49 |
|
TCTN2 |
79867 |
Q96GX1 |
0.49 |
|
TMEM67 |
91147 |
Q5HYA8 |
0.49 |
|
TMEM17 |
200728 |
Q86X19 |
0.49 |
|
EGFR |
1956 |
P00533 |
0.63 |
|
IKBKE |
9641 |
Q14164 |
0.63 |
|
EMC8 |
10328 |
O43402 |
0.63 |
|
EMC1 |
23065 |
Q8N766 |
0.63 |
|
ATP1B4 |
23439 |
Q9UN42 |
0.63 |
|
SDF2L1 |
23753 |
Q9HCN8 |
0.63 |
|
FBXO6 |
26270 |
Q9NRD1 |
0.63 |
|
DERL2 |
51009 |
Q9GZP9 |
0.63 |
|
EMC7 |
56851 |
Q9NPA0 |
0.63 |
|
CCDC8 |
83987 |
Q9H0W5 |
0.63 |
|
ENPP6 |
133121 |
Q6UWR7 |
0.63 |
|
UBAC2 |
337867 |
Q8NBM4 |
0.63 |
|
MMGT1 |
93380 |
Q8N4V1 |
0.82 |