Protein Description

Gene Symbol CTNNA2
Entrez ID 1496
Uniprot ID P26232
Description catenin alpha 2
Chromosomal Location chr2: 79,185,231-80,648,861
Ontology GO ID GO Term Definition Evidence

BP

GO:0007010

cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.

IEA

BP

GO:0007409

axonogenesis

De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon.

ISS

BP

GO:0016337

single organismal cell-cell adhesion

The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism.

ISS

BP

GO:0021942

radial glia guided migration of Purkinje cell

The migration of postmitotic a Purkinje cell along radial glial cells from the ventricular zone to the Purkinje cell layer.

ISS

BP

GO:0048813

dendrite morphogenesis

The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell.

ISS

BP

GO:0048854

brain morphogenesis

The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).

ISS

BP

GO:0051149

positive regulation of muscle cell differentiation

Any process that activates or increases the frequency, rate or extent of muscle cell differentiation.

TAS

BP

GO:0051823

regulation of synapse structural plasticity

Any process that modulates the frequency, rate or extent of synapse structural plasticity. Synapse structural plasticity is a type of cytoskeletal remodeling; this remodeling is induced by stimuli that can lead to long term potentiation and it can be activity-dependent or -independent. Examples of cytoskeletal changes include the formation of new spines and increase in spine size; this can be accompanied by the insertion of greater numbers of glutamate (or other neurotransmitter) receptors into the post-synaptic membrane.

ISS

BP

GO:0060134

prepulse inhibition

The process in which a startle magnitude is reduced when the startling stimulus is preceded by a low-intensity prepulse.

ISS

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IEA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0005912

adherens junction

A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.

ISS

CC

GO:0005913

cell-cell adherens junction

An adherens junction which connects a cell to another cell.

IDA

CC

GO:0015629

actin cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.

IEA

CC

GO:0016323

basolateral plasma membrane

The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.

IEA

CC

GO:0030027

lamellipodium

A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.

IEA

CC

GO:0030424

axon

The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.

ISS

MF

GO:0005200

structural constituent of cytoskeleton

The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.

NAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0051015

actin filament binding

Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.

IEA

MF

GO:0098641

cadherin binding involved in cell-cell adhesion

Any cadherin binding that occurs as part of the process of cell-cell adhesion.

IDA

Domain ID Description

IPR000633

Vinculin, conserved site

IPR001033

Alpha-catenin

IPR006077

Vinculin/alpha-catenin

IPR030046

Alpha N-catenin

Pathway ID Pathway Term Pathway Source

hsa04390

Hippo signaling pathway

KEGG

hsa04520

Adherens junction

KEGG

hsa04670

Leukocyte transendothelial migration

KEGG

hsa05100

Bacterial invasion of epithelial cells

KEGG

hsa05200

Pathways in cancer

KEGG

hsa05213

Endometrial cancer

KEGG

hsa05412

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

KEGG

WP2118

Arrhythmogenic Right Ventricular Cardiomyopathy

WikiPathways

WP2858

Ectoderm Differentiation

WikiPathways

h_cell2cellPathway

Cell to Cell Adhesion Signaling

BioCarta

UMLS CUI UMLS Term

C0002395

Alzheimer'S Disease

C0006142

Malignant Neoplasm Of Breast

C0038356

Stomach Neoplasms

No tissues found.

No databases found.

Pubmed ID Author Year Title

18765015

Qiao et al.

2008

Microarray evaluation of endometrial receptivity in Chinese women with polycystic ovary syndrome

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

CTNNBIP1

56998

Q9NSA3

0.52

CTNNB1

1499

P35222

0.58

ZNF639

51193

Q9UID6

0.77

PTPN14

5784

Q15678

0.52

AKT2

208

P31751

0.63

CD27

939

P26842

0.63

EGFR

1956

P00533

0.63

ESR2

2100

Q92731

0.63

MCM2

4171

P49736

0.63

NTRK1

4914

P04629

0.63

PPP2R1A

5518

P30153

0.63

GAN

8139

Q9H2C0

0.63

PAN2

9924

Q504Q3

0.63

YAP1

10413

P46937

0.63

UBD

10537

O15205

0.63

FBXW11

23291

Q9UKB1

0.63

UTP3

57050

Q9NQZ2

0.63

SAPCD1

401251

Q5SSQ6

0.63

SDHAF2

54949

Q9NX18

0.72

JUP

3728

P14923

0.73