Gene Symbol | CTNNA2 |
Entrez ID | 1496 |
Uniprot ID | P26232 |
Description | catenin alpha 2 |
Chromosomal Location | chr2: 79,185,231-80,648,861 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0007010 |
cytoskeleton organization |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. |
IEA |
BP |
GO:0007409 |
axonogenesis |
De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon. |
ISS |
BP |
GO:0016337 |
single organismal cell-cell adhesion |
The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism. |
ISS |
BP |
GO:0021942 |
radial glia guided migration of Purkinje cell |
The migration of postmitotic a Purkinje cell along radial glial cells from the ventricular zone to the Purkinje cell layer. |
ISS |
BP |
GO:0048813 |
dendrite morphogenesis |
The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell. |
ISS |
BP |
GO:0048854 |
brain morphogenesis |
The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
ISS |
BP |
GO:0051149 |
positive regulation of muscle cell differentiation |
Any process that activates or increases the frequency, rate or extent of muscle cell differentiation. |
TAS |
BP |
GO:0051823 |
regulation of synapse structural plasticity |
Any process that modulates the frequency, rate or extent of synapse structural plasticity. Synapse structural plasticity is a type of cytoskeletal remodeling; this remodeling is induced by stimuli that can lead to long term potentiation and it can be activity-dependent or -independent. Examples of cytoskeletal changes include the formation of new spines and increase in spine size; this can be accompanied by the insertion of greater numbers of glutamate (or other neurotransmitter) receptors into the post-synaptic membrane. |
ISS |
BP |
GO:0060134 |
prepulse inhibition |
The process in which a startle magnitude is reduced when the startling stimulus is preceded by a low-intensity prepulse. |
ISS |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IEA |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
CC |
GO:0005912 |
adherens junction |
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments. |
ISS |
CC |
GO:0005913 |
cell-cell adherens junction |
An adherens junction which connects a cell to another cell. |
IDA |
CC |
GO:0015629 |
actin cytoskeleton |
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
IEA |
CC |
GO:0016323 |
basolateral plasma membrane |
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
IEA |
CC |
GO:0030027 |
lamellipodium |
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. |
IEA |
CC |
GO:0030424 |
axon |
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
ISS |
MF |
GO:0005200 |
structural constituent of cytoskeleton |
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. |
NAS |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0051015 |
actin filament binding |
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
IEA |
MF |
GO:0098641 |
cadherin binding involved in cell-cell adhesion |
Any cadherin binding that occurs as part of the process of cell-cell adhesion. |
IDA |
Domain ID | Description |
---|---|
IPR000633 |
Vinculin, conserved site |
IPR001033 |
Alpha-catenin |
IPR006077 |
Vinculin/alpha-catenin |
IPR030046 |
Alpha N-catenin |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa04390 |
Hippo signaling pathway |
KEGG |
hsa04520 |
Adherens junction |
KEGG |
hsa04670 |
Leukocyte transendothelial migration |
KEGG |
hsa05100 |
Bacterial invasion of epithelial cells |
KEGG |
hsa05200 |
Pathways in cancer |
KEGG |
hsa05213 |
Endometrial cancer |
KEGG |
hsa05412 |
Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
KEGG |
WP2118 |
Arrhythmogenic Right Ventricular Cardiomyopathy |
WikiPathways |
WP2858 |
Ectoderm Differentiation |
WikiPathways |
h_cell2cellPathway |
Cell to Cell Adhesion Signaling |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0002395 |
Alzheimer'S Disease |
C0006142 |
Malignant Neoplasm Of Breast |
C0038356 |
Stomach Neoplasms |
Pubmed ID | Author | Year | Title |
---|---|---|---|
18765015 |
Qiao et al. |
2008 |
Microarray evaluation of endometrial receptivity in Chinese women with polycystic ovary syndrome |
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
CTNNBIP1 |
56998 |
Q9NSA3 |
0.52 |
CTNNB1 |
1499 |
P35222 |
0.58 |
ZNF639 |
51193 |
Q9UID6 |
0.77 |
PTPN14 |
5784 |
Q15678 |
0.52 |
AKT2 |
208 |
P31751 |
0.63 |
CD27 |
939 |
P26842 |
0.63 |
EGFR |
1956 |
P00533 |
0.63 |
ESR2 |
2100 |
Q92731 |
0.63 |
MCM2 |
4171 |
P49736 |
0.63 |
NTRK1 |
4914 |
P04629 |
0.63 |
PPP2R1A |
5518 |
P30153 |
0.63 |
GAN |
8139 |
Q9H2C0 |
0.63 |
PAN2 |
9924 |
Q504Q3 |
0.63 |
YAP1 |
10413 |
P46937 |
0.63 |
UBD |
10537 |
O15205 |
0.63 |
FBXW11 |
23291 |
Q9UKB1 |
0.63 |
UTP3 |
57050 |
Q9NQZ2 |
0.63 |
SAPCD1 |
401251 |
Q5SSQ6 |
0.63 |
SDHAF2 |
54949 |
Q9NX18 |
0.72 |
JUP |
3728 |
P14923 |
0.73 |