Gene Symbol | CTH |
Entrez ID | 1491 |
Uniprot ID | P32929 |
Description | cystathionine gamma-lyase |
Chromosomal Location | chr1: 70,411,218-70,439,851 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0000098 |
sulfur amino acid catabolic process |
The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine. |
TAS |
BP |
GO:0006534 |
cysteine metabolic process |
The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid. |
TAS |
BP |
GO:0018272 |
protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine |
The modification of peptidyl-lysine to form N6-pyridoxal phosphate-L-lysine. |
IDA |
BP |
GO:0019343 |
cysteine biosynthetic process via cystathionine |
The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine. |
IDA |
BP |
GO:0019344 |
cysteine biosynthetic process |
The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. |
IDA |
BP |
GO:0019346 |
transsulfuration |
The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes. |
IDA|TAS |
BP |
GO:0030968 |
endoplasmic reticulum unfolded protein response |
The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation. |
TAS |
BP |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling. |
IEA |
BP |
GO:0044524 |
protein sulfhydration |
The modification of a protein amino acid by the addition of sulfur. |
IMP |
BP |
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. |
IEA |
BP |
GO:0051289 |
protein homotetramerization |
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. |
IPI |
BP |
GO:0070814 |
hydrogen sulfide biosynthetic process |
The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S. |
IDA|TAS |
BP |
GO:0071266 |
de novo' L-methionine biosynthetic process |
The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid, from simpler components. |
IBA |
BP |
GO:1904831 |
positive regulation of aortic smooth muscle cell differentiation |
Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation. |
IMP |
BP |
GO:2001234 |
negative regulation of apoptotic signaling pathway |
Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway. |
IEA |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IBA|IDA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
MF |
GO:0003962 |
cystathionine gamma-synthase activity |
Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate. |
IBA |
MF |
GO:0004123 |
cystathionine gamma-lyase activity |
Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+. |
IDA|TAS |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0005516 |
calmodulin binding |
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
IEA |
MF |
GO:0016846 |
carbon-sulfur lyase activity |
Catalysis of the elimination of hydrogen sulfide or substituted H2S. |
TAS |
MF |
GO:0030170 |
pyridoxal phosphate binding |
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
IDA |
MF |
GO:0044540 |
L-cystine L-cysteine-lyase (deaminating) |
Catalysis of the reaction: L-cystine + H2O <=> pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide. |
IMP |
MF |
GO:0047982 |
homocysteine desulfhydrase activity |
Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate. |
TAS |
MF |
GO:0080146 |
L-cysteine desulfhydrase activity |
Catalysis of the reaction: L-cysteine + H2O = ammonia + pyruvate + hydrogen sulfide + H+. |
TAS |
Domain ID | Description |
---|---|
IPR000277 |
Cys/Met metabolism, pyridoxal phosphate-dependent enzyme |
IPR015421 |
Pyridoxal phosphate-dependent transferase, major region, subdomain 1 |
IPR015422 |
Pyridoxal phosphate-dependent transferase, subdomain 2 |
IPR015424 |
Pyridoxal phosphate-dependent transferase |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00260 |
Glycine, serine and threonine metabolism |
KEGG |
hsa00270 |
Cysteine and methionine metabolism |
KEGG |
hsa00450 |
Selenocompound metabolism |
KEGG |
hsa01100 |
Metabolic pathways |
KEGG |
hsa01230 |
Biosynthesis of amino acids |
KEGG |
WP2333 |
Trans-sulfuration pathway |
WikiPathways |
WP1533 |
Vitamin B12 Metabolism |
WikiPathways |
WP15 |
Selenium Micronutrient Network |
WikiPathways |
WP28 |
Selenium Metabolism and Selenoproteins |
WikiPathways |
WP3925 |
Amino Acid metabolism |
WikiPathways |
WP176 |
Folate Metabolism |
WikiPathways |
WP2525 |
Trans-sulfuration and one carbon metabolism |
WikiPathways |
WP3940 |
One carbon metabolism and related pathways |
WikiPathways |
h_methioninepathway |
Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine |
BioCarta |
Tissue | Cell Type |
---|---|
liver |
hepatocytes |
Pubmed ID | Author | Year | Title |
---|---|---|---|
12734205 |
Wood et al. |
2003 |
The Molecular Phenotype of Polycystic Ovary Syndrome (PCOS) Theca Cells and New Candidate PCOS Genes Defined by Microarray Analysis |
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
ACLY |
47 |
P53396 |
0.49 |
CTBP1 |
1487 |
Q13363 |
0.49 |
DUT |
1854 |
P33316 |
0.49 |
ENO2 |
2026 |
P09104 |
0.49 |
HSPE1 |
3336 |
P61604 |
0.49 |
PREP |
5550 |
P48147 |
0.49 |
RPE |
6120 |
Q96AT9 |
0.49 |
PAPSS2 |
9060 |
O95340 |
0.49 |
WDR1 |
9948 |
O75083 |
0.49 |
TP53RK |
112858 |
Q96S44 |
0.49 |
FDPS |
2224 |
P14324 |
0.56 |
SEC31A |
22872 |
O94979 |
0.56 |
CAPN2 |
824 |
P17655 |
0.63 |
PTMA |
5757 |
P06454 |
0.63 |
RECK |
8434 |
O95980 |
0.63 |
WDYHV1 |
55093 |
Q96HA8 |
0.63 |
GUCD1 |
83606 |
Q96NT3 |
0.63 |
ATIC |
471 |
P31939 |
0.70 |
CTH |
1491 |
P32929 |
0.79 |
CBS |
875 |
P35520 |
0.49 |
DLD |
1738 |
P09622 |
0.49 |
FOLH1 |
2346 |
Q04609 |
0.49 |
SERPINB8 |
5271 |
P50452 |
0.49 |
SGTA |
6449 |
O43765 |
0.49 |
TPD52L2 |
7165 |
O43399 |
0.49 |
NUTF2 |
10204 |
P61970 |
0.49 |
PFKM |
5213 |
P08237 |
0.56 |
ELAVL1 |
1994 |
Q15717 |
0.63 |
GMDS |
2762 |
O60547 |
0.63 |
SDCBP2 |
27111 |
Q9H190 |
0.63 |
ZSCAN32 |
54925 |
Q9NX65 |
0.63 |
FSD1 |
79187 |
Q9BTV5 |
0.63 |
SLC25A32 |
81034 |
Q9H2D1 |
0.63 |
SLC25A41 |
284427 |
Q8N5S1 |
0.63 |
YWHAZ |
7534 |
P63104 |
0.68 |
FOXI2 |
399823 |
Q6ZQN5 |
0.72 |