Protein Description

Gene Symbol CTH
Entrez ID 1491
Uniprot ID P32929
Description cystathionine gamma-lyase
Chromosomal Location chr1: 70,411,218-70,439,851
Ontology GO ID GO Term Definition Evidence

BP

GO:0000098

sulfur amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine.

TAS

BP

GO:0006534

cysteine metabolic process

The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid.

TAS

BP

GO:0018272

protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine

The modification of peptidyl-lysine to form N6-pyridoxal phosphate-L-lysine.

IDA

BP

GO:0019343

cysteine biosynthetic process via cystathionine

The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine.

IDA

BP

GO:0019344

cysteine biosynthetic process

The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid.

IDA

BP

GO:0019346

transsulfuration

The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes.

IDA|TAS

BP

GO:0030968

endoplasmic reticulum unfolded protein response

The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.

TAS

BP

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.

IEA

BP

GO:0044524

protein sulfhydration

The modification of a protein amino acid by the addition of sulfur.

IMP

BP

GO:0051092

positive regulation of NF-kappaB transcription factor activity

Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.

IEA

BP

GO:0051289

protein homotetramerization

The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.

IPI

BP

GO:0070814

hydrogen sulfide biosynthetic process

The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S.

IDA|TAS

BP

GO:0071266

de novo' L-methionine biosynthetic process

The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid, from simpler components.

IBA

BP

GO:1904831

positive regulation of aortic smooth muscle cell differentiation

Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation.

IMP

BP

GO:2001234

negative regulation of apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.

IEA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IBA|IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0003962

cystathionine gamma-synthase activity

Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate.

IBA

MF

GO:0004123

cystathionine gamma-lyase activity

Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+.

IDA|TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005516

calmodulin binding

Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.

IEA

MF

GO:0016846

carbon-sulfur lyase activity

Catalysis of the elimination of hydrogen sulfide or substituted H2S.

TAS

MF

GO:0030170

pyridoxal phosphate binding

Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

IDA

MF

GO:0044540

L-cystine L-cysteine-lyase (deaminating)

Catalysis of the reaction: L-cystine + H2O <=> pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide.

IMP

MF

GO:0047982

homocysteine desulfhydrase activity

Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate.

TAS

MF

GO:0080146

L-cysteine desulfhydrase activity

Catalysis of the reaction: L-cysteine + H2O = ammonia + pyruvate + hydrogen sulfide + H+.

TAS

Domain ID Description

IPR000277

Cys/Met metabolism, pyridoxal phosphate-dependent enzyme

IPR015421

Pyridoxal phosphate-dependent transferase, major region, subdomain 1

IPR015422

Pyridoxal phosphate-dependent transferase, subdomain 2

IPR015424

Pyridoxal phosphate-dependent transferase

Pathway ID Pathway Term Pathway Source

hsa00260

Glycine, serine and threonine metabolism

KEGG

hsa00270

Cysteine and methionine metabolism

KEGG

hsa00450

Selenocompound metabolism

KEGG

hsa01100

Metabolic pathways

KEGG

hsa01230

Biosynthesis of amino acids

KEGG

WP2333

Trans-sulfuration pathway

WikiPathways

WP1533

Vitamin B12 Metabolism

WikiPathways

WP15

Selenium Micronutrient Network

WikiPathways

WP28

Selenium Metabolism and Selenoproteins

WikiPathways

WP3925

Amino Acid metabolism

WikiPathways

WP176

Folate Metabolism

WikiPathways

WP2525

Trans-sulfuration and one carbon metabolism

WikiPathways

WP3940

One carbon metabolism and related pathways

WikiPathways

h_methioninepathway

Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine

BioCarta

No diseases found.

Tissue Cell Type

liver

hepatocytes

No databases found.

Pubmed ID Author Year Title

12734205

Wood et al.

2003

The Molecular Phenotype of Polycystic Ovary Syndrome (PCOS) Theca Cells and New Candidate PCOS Genes Defined by Microarray Analysis

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

ACLY

47

P53396

0.49

CTBP1

1487

Q13363

0.49

DUT

1854

P33316

0.49

ENO2

2026

P09104

0.49

HSPE1

3336

P61604

0.49

PREP

5550

P48147

0.49

RPE

6120

Q96AT9

0.49

PAPSS2

9060

O95340

0.49

WDR1

9948

O75083

0.49

TP53RK

112858

Q96S44

0.49

FDPS

2224

P14324

0.56

SEC31A

22872

O94979

0.56

CAPN2

824

P17655

0.63

PTMA

5757

P06454

0.63

RECK

8434

O95980

0.63

WDYHV1

55093

Q96HA8

0.63

GUCD1

83606

Q96NT3

0.63

ATIC

471

P31939

0.70

CTH

1491

P32929

0.79

CBS

875

P35520

0.49

DLD

1738

P09622

0.49

FOLH1

2346

Q04609

0.49

SERPINB8

5271

P50452

0.49

SGTA

6449

O43765

0.49

TPD52L2

7165

O43399

0.49

NUTF2

10204

P61970

0.49

PFKM

5213

P08237

0.56

ELAVL1

1994

Q15717

0.63

GMDS

2762

O60547

0.63

SDCBP2

27111

Q9H190

0.63

ZSCAN32

54925

Q9NX65

0.63

FSD1

79187

Q9BTV5

0.63

SLC25A32

81034

Q9H2D1

0.63

SLC25A41

284427

Q8N5S1

0.63

YWHAZ

7534

P63104

0.68

FOXI2

399823

Q6ZQN5

0.72