Protein Description

Gene Symbol PARVA
Entrez ID 55742
Uniprot ID Q9NVD7
Description parvin alpha
Chromosomal Location chr11: 12,377,185-12,530,801
Ontology GO ID GO Term Definition Evidence

BP

GO:0002040

sprouting angiogenesis

The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells.

ISS

BP

GO:0003148

outflow tract septum morphogenesis

The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract.

ISS

BP

GO:0007163

establishment or maintenance of cell polarity

Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.

ISS

BP

GO:0008360

regulation of cell shape

Any process that modulates the surface configuration of a cell.

IEA

BP

GO:0031532

actin cytoskeleton reorganization

A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.

IEA

BP

GO:0034113

heterotypic cell-cell adhesion

The attachment of a cell to a cell of a different type via adhesion molecules.

ISS

BP

GO:0034446

substrate adhesion-dependent cell spreading

The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.

IMP

BP

GO:0060271

cilium morphogenesis

A process that is carried out at the cellular level and in which the structure of a cilium is organized.

IMP

BP

GO:0070252

actin-mediated cell contraction

The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body.

ISS

BP

GO:0071670

smooth muscle cell chemotaxis

The directed movement of a smooth muscle cell in response to an external stimulus.

ISS

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0005856

cytoskeleton

Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

IEA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IEA

CC

GO:0005913

cell-cell adherens junction

An adherens junction which connects a cell to another cell.

IDA

CC

GO:0005925

focal adhesion

Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.

IDA

CC

GO:0030018

Z disc

Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.

IEA

MF

GO:0003779

actin binding

Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.

IEA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0098641

cadherin binding involved in cell-cell adhesion

Any cadherin binding that occurs as part of the process of cell-cell adhesion.

IDA

Domain ID Description

IPR001715

Calponin homology domain

IPR028433

Parvin

Pathway ID Pathway Term Pathway Source

hsa04510

Focal adhesion

KEGG

WP2572

Primary Focal Segmental Glomerulosclerosis FSGS

WikiPathways

UMLS CUI UMLS Term

C0086132

Depressive Symptoms

C0236969

Substance-Related Disorders

Tissue Cell Type

adrenal gland

glandular cells

appendix

lymphoid tissue

bone marrow

hematopoietic cells

breast

glandular cells

breast

myoepithelial cells

cerebral cortex

endothelial cells

duodenum

glandular cells

endometrium

glandular cells

gallbladder

glandular cells

heart muscle

myocytes

lung

macrophages

lymph node

germinal center cells

lymph node

non-germinal center cells

pancreas

exocrine glandular cells

placenta

decidual cells

rectum

glandular cells

skeletal muscle

myocytes

small intestine

glandular cells

smooth muscle

smooth muscle cells

spleen

cells in red pulp

spleen

cells in white pulp

stomach

glandular cells

tonsil

germinal center cells

tonsil

non-germinal center cells

tonsil

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

17148555

Wood et al.

2007

Molecular Abnormalities in Oocytes from Women with Polycystic Ovary Syndrome Revealed by Microarray Analysis

Gene Symbol Entrez ID Uniprot ID Score

ACTA1

58

P68133

0.52

APP

351

P05067

0.56

ENO1

2023

P06733

0.63

MBP

4155

P02686

0.63

IQGAP1

8826

P46940

0.63

SEC24C

9632

P53992

0.63

HSPH1

10808

Q92598

0.63

ADGRL1

22859

O94910

0.63

GCA

25801

P28676

0.63

PARVB

29780

Q9HBI1

0.63

UBQLN1

29979

Q9UMX0

0.63

DDX47

51202

Q9H0S4

0.63

VPS11

55823

Q9H270

0.63

COL27A1

85301

Q8IZC6

0.63

RSU1

6251

Q15404

0.74

DHX36

170506

Q9H2U1

0.76

PXN

5829

P49023

0.89

LIMS1

3987

P48059

0.90

ILK

3611

Q13418

0.99

ACTB

60

P60709

0.00

ITGA2

3673

P17301

0.00

ITGA2B

3674

P08514

0.00

ITGA3

3675

P26006

0.00

ITGA4

3676

P13612

0.00

ITGA9

3680

Q13797

0.00

ITGAV

3685

P06756

0.00

ITGB1

3688

P05556

0.00

ITGB3

3690

P05106

0.00

ITGB4

3691

P16144

0.00

ITGB5

3693

P18084

0.00

ITGB8

3696

P26012

0.00

ITGA11

22801

Q9UKX5

0.00

DDX17

10521

Q92841

0.49

CHMP2A

27243

O43633

0.49

DPH5

51611

Q9H2P9

0.49

CMTR2

55783

Q8IYT2

0.49

MAP2K1

5604

Q02750

0.52

CDC5L

988

Q99459

0.63

CRMP1

1400

Q14194

0.63

ELAVL1

1994

Q15717

0.63

GCNT1

2650

Q02742

0.63

HSPB2

3316

Q16082

0.63

ATXN3

4287

P54252

0.63

MLH1

4292

P40692

0.63

OSBP

5007

P22059

0.63

PPAT

5471

Q06203

0.63

SOX2

6657

P48431

0.63

UBE3A

7337

Q05086

0.63

UGP2

7360

Q16851

0.63

ZRANB2

9406

O95218

0.63

CARM1

10498

Q86X55

0.63

SNW1

22938

Q13573

0.63

DNAJB5

25822

O75953

0.63

OTUD6B

51633

Q8N6M0

0.63

CORO1B

57175

Q9BR76

0.63

TBC1D17

79735

Q9HA65

0.63

MOCOS

55034

Q96EN8

0.83