| Gene Symbol | PARVA |
| Entrez ID | 55742 |
| Uniprot ID | Q9NVD7 |
| Description | parvin alpha |
| Chromosomal Location | chr11: 12,377,185-12,530,801 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0002040 |
sprouting angiogenesis |
The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells. |
ISS |
|
BP |
GO:0003148 |
outflow tract septum morphogenesis |
The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract. |
ISS |
|
BP |
GO:0007163 |
establishment or maintenance of cell polarity |
Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. |
ISS |
|
BP |
GO:0008360 |
regulation of cell shape |
Any process that modulates the surface configuration of a cell. |
IEA |
|
BP |
GO:0031532 |
actin cytoskeleton reorganization |
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins. |
IEA |
|
BP |
GO:0034113 |
heterotypic cell-cell adhesion |
The attachment of a cell to a cell of a different type via adhesion molecules. |
ISS |
|
BP |
GO:0034446 |
substrate adhesion-dependent cell spreading |
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. |
IMP |
|
BP |
GO:0060271 |
cilium morphogenesis |
A process that is carried out at the cellular level and in which the structure of a cilium is organized. |
IMP |
|
BP |
GO:0070252 |
actin-mediated cell contraction |
The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body. |
ISS |
|
BP |
GO:0071670 |
smooth muscle cell chemotaxis |
The directed movement of a smooth muscle cell in response to an external stimulus. |
ISS |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
|
CC |
GO:0005856 |
cytoskeleton |
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
IEA |
|
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
IEA |
|
CC |
GO:0005913 |
cell-cell adherens junction |
An adherens junction which connects a cell to another cell. |
IDA |
|
CC |
GO:0005925 |
focal adhesion |
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. |
IDA |
|
CC |
GO:0030018 |
Z disc |
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. |
IEA |
|
MF |
GO:0003779 |
actin binding |
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. |
IEA |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0098641 |
cadherin binding involved in cell-cell adhesion |
Any cadherin binding that occurs as part of the process of cell-cell adhesion. |
IDA |
| Domain ID | Description |
|---|---|
|
IPR001715 |
Calponin homology domain |
|
IPR028433 |
Parvin |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa04510 |
Focal adhesion |
KEGG |
|
WP2572 |
Primary Focal Segmental Glomerulosclerosis FSGS |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0086132 |
Depressive Symptoms |
|
C0236969 |
Substance-Related Disorders |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
lymphoid tissue |
|
bone marrow |
hematopoietic cells |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
cerebral cortex |
endothelial cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
lung |
macrophages |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
pancreas |
exocrine glandular cells |
|
placenta |
decidual cells |
|
rectum |
glandular cells |
|
skeletal muscle |
myocytes |
|
small intestine |
glandular cells |
|
smooth muscle |
smooth muscle cells |
|
spleen |
cells in red pulp |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
17148555 |
Wood et al. |
2007 |
Molecular Abnormalities in Oocytes from Women with Polycystic Ovary Syndrome Revealed by Microarray Analysis |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
ACTA1 |
58 |
P68133 |
0.52 |
|
APP |
351 |
P05067 |
0.56 |
|
ENO1 |
2023 |
P06733 |
0.63 |
|
MBP |
4155 |
P02686 |
0.63 |
|
IQGAP1 |
8826 |
P46940 |
0.63 |
|
SEC24C |
9632 |
P53992 |
0.63 |
|
HSPH1 |
10808 |
Q92598 |
0.63 |
|
ADGRL1 |
22859 |
O94910 |
0.63 |
|
GCA |
25801 |
P28676 |
0.63 |
|
PARVB |
29780 |
Q9HBI1 |
0.63 |
|
UBQLN1 |
29979 |
Q9UMX0 |
0.63 |
|
DDX47 |
51202 |
Q9H0S4 |
0.63 |
|
VPS11 |
55823 |
Q9H270 |
0.63 |
|
COL27A1 |
85301 |
Q8IZC6 |
0.63 |
|
RSU1 |
6251 |
Q15404 |
0.74 |
|
DHX36 |
170506 |
Q9H2U1 |
0.76 |
|
PXN |
5829 |
P49023 |
0.89 |
|
LIMS1 |
3987 |
P48059 |
0.90 |
|
ILK |
3611 |
Q13418 |
0.99 |
|
ACTB |
60 |
P60709 |
0.00 |
|
ITGA2 |
3673 |
P17301 |
0.00 |
|
ITGA2B |
3674 |
P08514 |
0.00 |
|
ITGA3 |
3675 |
P26006 |
0.00 |
|
ITGA4 |
3676 |
P13612 |
0.00 |
|
ITGA9 |
3680 |
Q13797 |
0.00 |
|
ITGAV |
3685 |
P06756 |
0.00 |
|
ITGB1 |
3688 |
P05556 |
0.00 |
|
ITGB3 |
3690 |
P05106 |
0.00 |
|
ITGB4 |
3691 |
P16144 |
0.00 |
|
ITGB5 |
3693 |
P18084 |
0.00 |
|
ITGB8 |
3696 |
P26012 |
0.00 |
|
ITGA11 |
22801 |
Q9UKX5 |
0.00 |
|
DDX17 |
10521 |
Q92841 |
0.49 |
|
CHMP2A |
27243 |
O43633 |
0.49 |
|
DPH5 |
51611 |
Q9H2P9 |
0.49 |
|
CMTR2 |
55783 |
Q8IYT2 |
0.49 |
|
MAP2K1 |
5604 |
Q02750 |
0.52 |
|
CDC5L |
988 |
Q99459 |
0.63 |
|
CRMP1 |
1400 |
Q14194 |
0.63 |
|
ELAVL1 |
1994 |
Q15717 |
0.63 |
|
GCNT1 |
2650 |
Q02742 |
0.63 |
|
HSPB2 |
3316 |
Q16082 |
0.63 |
|
ATXN3 |
4287 |
P54252 |
0.63 |
|
MLH1 |
4292 |
P40692 |
0.63 |
|
OSBP |
5007 |
P22059 |
0.63 |
|
PPAT |
5471 |
Q06203 |
0.63 |
|
SOX2 |
6657 |
P48431 |
0.63 |
|
UBE3A |
7337 |
Q05086 |
0.63 |
|
UGP2 |
7360 |
Q16851 |
0.63 |
|
ZRANB2 |
9406 |
O95218 |
0.63 |
|
CARM1 |
10498 |
Q86X55 |
0.63 |
|
SNW1 |
22938 |
Q13573 |
0.63 |
|
DNAJB5 |
25822 |
O75953 |
0.63 |
|
OTUD6B |
51633 |
Q8N6M0 |
0.63 |
|
CORO1B |
57175 |
Q9BR76 |
0.63 |
|
TBC1D17 |
79735 |
Q9HA65 |
0.63 |
|
MOCOS |
55034 |
Q96EN8 |
0.83 |