Protein Description

Gene Symbol FAR2
Entrez ID 55711
Uniprot ID Q96K12
Description fatty acyl-CoA reductase 2
Chromosomal Location chr12: 29,149,103-29,340,980
Ontology GO ID GO Term Definition Evidence

BP

GO:0006629

lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

IEA

BP

GO:0010025

wax biosynthetic process

The chemical reactions and pathways resulting in the formation of wax, which includes C16 and C18 fatty acids.

IBA|TAS

BP

GO:0035336

long-chain fatty-acyl-CoA metabolic process

The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.

IDA

BP

GO:0055114

oxidation-reduction process

A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.

IEA

CC

GO:0005777

peroxisome

A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

IBA|ISS

CC

GO:0005778

peroxisomal membrane

The lipid bilayer surrounding a peroxisome.

IEA

CC

GO:0005782

peroxisomal matrix

The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase.

TAS

CC

GO:0005789

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

IEA

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

MF

GO:0016491

oxidoreductase activity

Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

TAS

MF

GO:0050062

long-chain-fatty-acyl-CoA reductase activity

Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH.

IEA

MF

GO:0080019

fatty-acyl-CoA reductase (alcohol-forming) activity

Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA.

IDA

Domain ID Description

IPR013120

Male sterility, NAD-binding

IPR016040

NAD(P)-binding domain

IPR026055

Fatty acyl-CoA reductase

IPR033640

Fatty acyl-CoA reductase, C-terminal

Pathway ID Pathway Term Pathway Source

hsa04146

Peroxisome

KEGG

No diseases found.

Tissue Cell Type

appendix

glandular cells

cerebellum

Purkinje cells

endometrium

glandular cells

gallbladder

glandular cells

hippocampus

neuronal cells

pancreas

exocrine glandular cells

placenta

decidual cells

placenta

trophoblastic cells

rectum

glandular cells

small intestine

glandular cells

stomach

glandular cells

No databases found.

Pubmed ID Author Year Title

22904171

Kaur et al.

2012

Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis

Gene Symbol Entrez ID Uniprot ID Score

PEX19

5824

P40855

0.63

UBD

10537

O15205

0.63

VSIG4

11326

Q9Y279

0.63

ERGIC3

51614

Q9Y282

0.63

SLC39A4

55630

Q6P5W5

0.63

IQCF1

132141

Q8N6M8

0.63