Gene Symbol | FAR2 |
Entrez ID | 55711 |
Uniprot ID | Q96K12 |
Description | fatty acyl-CoA reductase 2 |
Chromosomal Location | chr12: 29,149,103-29,340,980 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006629 |
lipid metabolic process |
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. |
IEA |
BP |
GO:0010025 |
wax biosynthetic process |
The chemical reactions and pathways resulting in the formation of wax, which includes C16 and C18 fatty acids. |
IBA|TAS |
BP |
GO:0035336 |
long-chain fatty-acyl-CoA metabolic process |
The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more. |
IDA |
BP |
GO:0055114 |
oxidation-reduction process |
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
IEA |
CC |
GO:0005777 |
peroxisome |
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. |
IBA|ISS |
CC |
GO:0005778 |
peroxisomal membrane |
The lipid bilayer surrounding a peroxisome. |
IEA |
CC |
GO:0005782 |
peroxisomal matrix |
The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase. |
TAS |
CC |
GO:0005789 |
endoplasmic reticulum membrane |
The lipid bilayer surrounding the endoplasmic reticulum. |
IEA |
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IEA |
MF |
GO:0016491 |
oxidoreductase activity |
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
TAS |
MF |
GO:0050062 |
long-chain-fatty-acyl-CoA reductase activity |
Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH. |
IEA |
MF |
GO:0080019 |
fatty-acyl-CoA reductase (alcohol-forming) activity |
Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA. |
IDA |
Domain ID | Description |
---|---|
IPR013120 |
Male sterility, NAD-binding |
IPR016040 |
NAD(P)-binding domain |
IPR026055 |
Fatty acyl-CoA reductase |
IPR033640 |
Fatty acyl-CoA reductase, C-terminal |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa04146 |
Peroxisome |
KEGG |
Tissue | Cell Type |
---|---|
appendix |
glandular cells |
cerebellum |
Purkinje cells |
endometrium |
glandular cells |
gallbladder |
glandular cells |
hippocampus |
neuronal cells |
pancreas |
exocrine glandular cells |
placenta |
decidual cells |
placenta |
trophoblastic cells |
rectum |
glandular cells |
small intestine |
glandular cells |
stomach |
glandular cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22904171 |
Kaur et al. |
2012 |
Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
PEX19 |
5824 |
P40855 |
0.63 |
UBD |
10537 |
O15205 |
0.63 |
VSIG4 |
11326 |
Q9Y279 |
0.63 |
ERGIC3 |
51614 |
Q9Y282 |
0.63 |
SLC39A4 |
55630 |
Q6P5W5 |
0.63 |
IQCF1 |
132141 |
Q8N6M8 |
0.63 |