PCOSBase

Protein Description

Gene Symbol	PPP4R3A
Entrez ID	55671
Uniprot ID	Q6IN85
Description	protein phosphatase 4 regulatory subunit 3A
Chromosomal Location	chr14: 91,457,611-91,510,554

Ontology	GO ID	GO Term	Definition	Evidence
CC	GO:0005634	nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	IEA
CC	GO:0005737	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	IEA
CC	GO:0005815	microtubule organizing center	An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.	IEA

Domain ID	Description
IPR006887	Domain of unknown function DUF625
IPR011989	Armadillo-like helical
IPR011993	PH domain-like
IPR016024	Armadillo-type fold

Pathway ID	Pathway Term	Pathway Source
hsa04922	Glucagon signaling pathway	KEGG
WP1984	Integrated Breast Cancer Pathway	WikiPathways

Tissue	Cell Type
adrenal gland	glandular cells
breast	glandular cells
bronchus	respiratory epithelial cells
cerebellum	cells in molecular layer
cerebral cortex	neuronal cells
cervix, uterine	glandular cells
colon	glandular cells
colon	peripheral nerve/ganglion
duodenum	glandular cells
endometrium	glandular cells
epididymis	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
gallbladder	glandular cells
hippocampus	neuronal cells
kidney	cells in glomeruli
kidney	cells in tubules
nasopharynx	respiratory epithelial cells
pancreas	islets of Langerhans
parathyroid gland	glandular cells
placenta	decidual cells
placenta	trophoblastic cells
salivary gland	glandular cells
seminal vesicle	glandular cells
skin	keratinocytes
skin	epidermal cells
soft tissue	adipocytes
stomach	glandular cells
testis	cells in seminiferous ducts
thyroid gland	glandular cells
tonsil	squamous epithelial cells
urinary bladder	urothelial cells

Pubmed ID	Author	Year	Title
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol	Entrez ID	Uniprot ID	Score
ACAT2	39	Q9BWD1	0.49
SNX3	8724	O60493	0.49
EHMT2	10919	Q96KQ7	0.49
SNX12	29934	Q9UMY4	0.49
CCAR2	57805	Q8N163	0.49
EHMT1	79813	Q9H9B1	0.49
POLR2A	5430	P24928	0.59
AMPD2	271	Q01433	0.63
CAST	831	P20810	0.63
MAPK14	1432	Q16539	0.63
DDB2	1643	Q92466	0.63
HDAC1	3065	Q13547	0.63
PSMA2	5683	P25787	0.63
PSMB1	5689	P20618	0.63
MTA2	9219	O94776	0.63
TELO2	9894	Q9Y4R8	0.63
HNRNPR	10236	O43390	0.63
COG4	25839	Q9H9E3	0.63
BRCC3	79184	P46736	0.63
LRRK2	120892	Q5S007	0.63
BUB1B	701	O60566	0.72
CLK1	1195	P49759	0.72
MED1	5469	Q15648	0.72
PTPRA	5786	P18433	0.72
DHX38	9785	Q92620	0.72
COBLL1	22837	Q53SF7	0.72
SLC4A1AP	22950	Q9BWU0	0.72
FBXO28	23219	Q9NVF7	0.72
SIRT1	23411	Q96EB6	0.72
NECTIN3	25945	Q9NQS3	0.72
ITSN2	50618	Q9NZM3	0.72
NSFL1C	55968	Q9UNZ2	0.72
XAB2	56949	Q9HCS7	0.72
SCAF4	57466	O95104	0.72
CACTIN	58509	Q8WUQ7	0.72
DOCK5	80005	Q9H7D0	0.72
LRCH3	84859	Q96II8	0.72
KNSTRN	90417	Q9Y448	0.72
FKBP1A	2280	P62942	0.49
GAPDH	2597	P04406	0.49
IGBP1	3476	P78318	0.49
CPSF6	11052	Q16630	0.49
ACACA	31	Q13085	0.63
ARCN1	372	P48444	0.63
NTRK1	4914	P04629	0.63
CASK	8573	O14936	0.63
PMPCB	9512	O75439	0.63
HUWE1	10075	Q7Z6Z7	0.63
TSSC4	10078	Q9Y5U2	0.63
SF3A1	10291	Q15459	0.63
ALKBH3	221120	Q96Q83	0.63
NELL1	4745	Q92832	0.65
PPP4C	5531	P60510	0.90
PPP4R2	151987	Q9NY27	0.90