| Gene Symbol | CSTF3 |
| Entrez ID | 1479 |
| Uniprot ID | Q12996 |
| Description | cleavage stimulation factor, 3' pre-RNA, subunit 3 |
| Chromosomal Location | chr11: 33,077,188-33,162,371 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0000398 |
mRNA splicing, via spliceosome |
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
TAS |
|
BP |
GO:0006369 |
termination of RNA polymerase II transcription |
The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed. |
TAS |
|
BP |
GO:0006378 |
mRNA polyadenylation |
The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript. |
TAS |
|
BP |
GO:0006379 |
mRNA cleavage |
Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. |
TAS |
|
BP |
GO:0031124 |
mRNA 3'-end processing |
Any process involved in forming the mature 3' end of an mRNA molecule. |
TAS |
|
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
TAS |
|
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
IDA|TAS |
|
MF |
GO:0003723 |
RNA binding |
Interacting selectively and non-covalently with an RNA molecule or a portion thereof. |
TAS |
|
MF |
GO:0003729 |
mRNA binding |
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
IBA |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
| Domain ID | Description |
|---|---|
|
IPR003107 |
HAT (Half-A-TPR) repeat |
|
IPR008847 |
Suppressor of forked |
|
IPR011990 |
Tetratricopeptide-like helical domain |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa03015 |
mRNA surveillance pathway |
KEGG |
|
WP411 |
mRNA Processing |
WikiPathways |
|
h_cpsfPathway |
Polyadenylation of mRNA |
BioCarta |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
bone marrow |
hematopoietic cells |
|
breast |
glandular cells |
|
bronchus |
respiratory epithelial cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
cells in molecular layer |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
endometrium |
cells in endometrial stroma |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
kidney |
cells in tubules |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
pancreas |
exocrine glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
skeletal muscle |
myocytes |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
smooth muscle |
smooth muscle cells |
|
soft tissue |
chondrocytes |
|
soft tissue |
fibroblasts |
|
spleen |
cells in red pulp |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
GAPDH |
2597 |
P04406 |
0.49 |
|
PABPC3 |
5042 |
Q9H361 |
0.49 |
|
PAPOLB |
56903 |
Q9NRJ5 |
0.49 |
|
PABPC1 |
26986 |
P11940 |
0.56 |
|
CSTF2T |
23283 |
Q9H0L4 |
0.59 |
|
E2F4 |
1874 |
Q16254 |
0.52 |
|
XPO1 |
7514 |
O14980 |
0.56 |
|
RRAGA |
10670 |
Q7L523 |
0.56 |
|
PAPOLA |
10914 |
P51003 |
0.56 |
|
CPSF1 |
29894 |
Q10570 |
0.56 |
|
CDC5L |
988 |
Q99459 |
0.63 |
|
CDK4 |
1019 |
P11802 |
0.63 |
|
CYP1A1 |
1543 |
P04798 |
0.63 |
|
HNRNPA1 |
3178 |
P09651 |
0.63 |
|
NPM1 |
4869 |
P06748 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
RBBP6 |
5930 |
Q7Z6E9 |
0.63 |
|
WHSC1 |
7468 |
O96028 |
0.63 |
|
CUL3 |
8452 |
Q13618 |
0.63 |
|
IKBKE |
9641 |
Q14164 |
0.63 |
|
CUL7 |
9820 |
Q14999 |
0.63 |
|
SNW1 |
22938 |
Q13573 |
0.63 |
|
MACROD1 |
28992 |
Q9BQ69 |
0.63 |
|
WWOX |
51741 |
Q9NZC7 |
0.63 |
|
HECW2 |
57520 |
Q9P2P5 |
0.63 |
|
CDC73 |
79577 |
Q6P1J9 |
0.63 |
|
CCNL2 |
81669 |
Q96S94 |
0.63 |
|
UNK |
85451 |
Q9C0B0 |
0.63 |
|
SCARNA22 |
677770 |
N/A |
0.63 |
|
SYMPK |
8189 |
Q92797 |
0.72 |
|
RNPS1 |
10921 |
Q15287 |
0.72 |
|
CEP170P1 |
645455 |
Q96L14 |
0.72 |
|
CSTF1 |
1477 |
Q05048 |
0.76 |
|
VHL |
7428 |
P40337 |
0.76 |
|
CPSF3 |
51692 |
Q9UKF6 |
0.79 |
|
FIP1L1 |
81608 |
Q6UN15 |
0.84 |
|
POLR2A |
5430 |
P24928 |
0.86 |
|
CSTF2 |
1478 |
P33240 |
0.96 |